David W. Manning

ORCID: 0009-0001-0677-8118
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About
Contact & Profiles
Research Areas
  • Total Knee Arthroplasty Outcomes
  • Orthopaedic implants and arthroplasty
  • Orthopedic Infections and Treatments
  • Anesthesia and Pain Management
  • Hip disorders and treatments
  • Hip and Femur Fractures
  • Venous Thromboembolism Diagnosis and Management
  • Cardiac, Anesthesia and Surgical Outcomes
  • Spine and Intervertebral Disc Pathology
  • Nausea and vomiting management
  • Pelvic and Acetabular Injuries
  • Surgical Sutures and Adhesives
  • Knee injuries and reconstruction techniques
  • Shoulder Injury and Treatment
  • Surgical site infection prevention
  • Atrial Fibrillation Management and Outcomes
  • Musculoskeletal pain and rehabilitation
  • Pain Mechanisms and Treatments
  • Acute Myocardial Infarction Research
  • Organ Donation and Transplantation
  • Neuroethics, Human Enhancement, Biomedical Innovations
  • Clinical practice guidelines implementation
  • Bone and Joint Diseases
  • Vascular Procedures and Complications
  • Dental Anxiety and Anesthesia Techniques

Northwestern University
2015-2025

Northwestern Memorial Hospital
2023

BC Studies
2020

Clinical Orthopaedics and Related Research
2018

Zimmer Biomet (United States)
2018

Medacta (United States)
2018

Rosalind Franklin University of Medicine and Science
2018

Manning Diversified Forest Products (Canada)
2018

University of Chicago
2005-2012

University of Chicago Medical Center
2005-2010

Abstract Efficacious bone regeneration could revolutionize the clinical management of many and musculoskeletal disorders. Bone morphogenetic proteins (BMPs) can regulate differentiation mesenchymal stem cells into cartilage, bone, tendon/ligament, fat lineages. Early data documented osteogenic potential rhBMP2 rhBMP7/OP‐1. However, prior to this work that summarized several our recent studies, no comprehensive analysis had been undertaken characterize relative activity all BMPs. Using...

10.1002/jor.20359 article EN Journal of Orthopaedic Research® 2007-02-08

<h3>Background and Objectives</h3> A single-dose adductor canal block can provide postoperative analgesia for patients undergoing total knee arthroplasty (TKA). The purpose of this study was to assess opioid consumption after ultrasound-guided single-injection bupivacaine compared with saline TKA. <h3>Methods</h3> After institutional review board approval, written informed consent obtained from (&gt;18 years old) elective Subjects were randomized into 2 groups as follows: blockade 10 mL...

10.1097/aap.0000000000000494 article EN Regional Anesthesia & Pain Medicine 2016-01-01

Background: Readmissions following total hip arthroplasty are a focus given the forthcoming financial penalties that hospitals in United States may incur starting 2015. The purpose of this study was to identify both preoperative comorbidities and postoperative conditions increase risk readmission arthroplasty. Methods: Using American College Surgeons–National Surgical Quality Improvement Program data for 2011, population identified using Current Procedural Terminology code primary (27130)....

10.2106/jbjs.m.00556 article EN Journal of Bone and Joint Surgery 2014-07-16

Patients with diabetes are known to be at greater risk for complications after arthroplasty than patients without diabetes. However, we do not know whether there important differences in the of perioperative between who insulin-dependent (Type 1 or 2) and those insulin-dependent.The purpose our study was compare (1) medical (including death), (2) surgical complications, (3) readmissions within 30 days noninsulin-dependent diabetes, have diabetes.A total 43,299 undergoing THA TKA 2005 2011...

10.1007/s11999-014-3891-4 article EN Clinical Orthopaedics and Related Research 2014-08-19

Background. Urinary tract infections (UTIs) are the most common minor complication following total joint arthroplasty (TJA) with incidence as high 3.26%. Bladder catheterization is routinely used during TJA and Centers for Medicare Medicaid Services (CMS) has recently identified hospital-acquired catheter associated UTI a target quality improvement. This investigation seeks to identify specific risk factors in patients. Methods. We retrospectively studied patients undergoing osteoarthritis...

10.1155/2016/7268985 article EN cc-by Advances in Orthopedics 2016-01-01

Background and objectives Refractory chronic knee pain from osteoarthritis (OA) is commonly treated with total arthroplasty (TKA). TKA can be associated severe postoperative persistent postsurgical pain. Poorly controlled negatively effect functional outcomes following TKA, effective opioid-sparing analgesia key to the ideal recovery. Genicular nerve radiofrequency ablation (GN-RFA) has been shown in several trials clinically patients refractory OA. We aimed assess if preoperative GN-RFA...

10.1136/rapm-2018-100094 article EN Regional Anesthesia & Pain Medicine 2019-04-25

Direct anterior approach total hip arthroplasty (DA THA) has been reported to improve early outcomes compared posterior THA up 6 weeks postoperatively. Limited weekly data are available prior weeks. We evaluate including when patients first drive a car, leave home, and discontinue their assist device.Patients undergoing for primary osteoarthritis were prospectively enrolled. Outcomes collected preoperatively postoperatively at intervals weeks.111 (55 DA 56 approach) There was no significant...

10.1177/1120700019881413 article EN Hip International 2019-10-06

ABSTRACT First‐in‐human pig xenotransplant clinical trials may soon begin, which raises ethical concerns about patients’ decision‐making to participate in such trials. We assessed kidney transplant candidates’ attitudes and hypothetical participating through semi‐structured telephone interviews an online survey. analyzed qualitative data by thematic analysis quantitative descriptive statistics. Twenty‐eight patients participated interviews; 142 the Most interview survey respondents were male...

10.1111/xen.70013 article EN cc-by-nc-nd Xenotransplantation 2025-01-01

Transplant programs preparing to initiate first-in-human pig kidney xenotransplant clinical trials must be especially careful when obtaining participants' informed consent. Little is known about the kind of information patients want for making an decision trial participation. We conducted semi-structured telephone interviews with waitlisted transplant needs regarding participating in a trial, which guided development prototype consent form. Subsequent usability testing sought patient...

10.1111/xen.70016 article EN cc-by-nc-nd Xenotransplantation 2025-01-01

In Brief Study Design. Parallel design, prospective, double-blind, randomized, controlled trial composed of two independent groups treated with a continuous infusion catheter (saline vs. Marcaine) placed into the iliac crest bone graft (ICBG) site. Objective. To determine effects postoperative local anesthetic agent at ICBG harvest site in reducing pain, narcotic demand and usage, improving early function after spinal fusion. Summary Background Data. Harvesting has been shown to be source...

10.1097/01.brs.0000186323.11285.b1 article EN Spine 2005-11-01

The modified Harris Hip Score (mHHS) is a validated and disease-specific instrument commonly used to assess outcomes in total hip arthroplasty (THA). Patient-Reported Outcomes Measurement Information System (PROMIS) validated, computer adaptive testing (CAT)–based global health assessment tool. authors' goal was examine the correlation between PROMIS Pain Interference Physical Function CATs mHHS patients undergoing primary THA. All THAs were performed by 1 of 2 fellowship-trained dedicated...

10.3928/01477447-20201202-02 article EN Orthopedics 2020-12-07
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