A5079776083- Extracellular vesicles in disease
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Essential Oils and Antimicrobial Activity
- Liver Disease Diagnosis and Treatment
- Genomics, phytochemicals, and oxidative stress
- Multiple Myeloma Research and Treatments
- Skin Protection and Aging
- Phytochemicals and Antioxidant Activities
- Ginger and Zingiberaceae research
- Inflammasome and immune disorders
- Olfactory and Sensory Function Studies
- Natural product bioactivities and synthesis
- Curcumin's Biomedical Applications
- Gut microbiota and health
- Liver physiology and pathology
- Drug-Induced Hepatotoxicity and Protection
- Inflammatory Bowel Disease
- Cell Adhesion Molecules Research
University of Palermo
2017-2024
In the last years, extracellular vesicles (EVs) from different plant matrices have been isolated and gained interest of scientific community for their intriguing biological properties. this study, we characterized nanovesicles lemon juice (LNVs) evaluated antioxidant effects. We tested LNV activity using human dermal fibroblasts that were pre-treated with LNVs 24 h then stimulated hydrogen peroxide (H
Plant-derived nanovesicles (PDNVs) have recently emerged as natural delivery systems of biofunctional compounds toward mammalian cells. Considering their already described composition, anti-inflammatory properties, stability, and low toxicity, PDNVs offer a promising path for developing new preventive strategies several inflammatory diseases, among which the bowel disease (IBD). In this study, we explore protective effects industrially produced lemon vesicles (iLNVs) in rat model IBD....
In the last years, field of nanomedicine and drug delivery has grown exponentially, providing new platforms to carry therapeutic agents into target sites. Extracellular vesicles (EVs) are ready-to-use, biocompatible, non-toxic nanoparticles that revolutionizing delivery. EVs involved in cell–cell communication mediate many physiological pathological processes by transferring their bioactive cargo cells. Recently, nanovesicles from plants (PDNVs) raising interest scientific community due high...
Lemon essential oil (LEO) is a well-known flavoring agent with versatile biological activities. In the present study, we have isolated and characterized four citral-enriched fractions of winter LEO. We reported that in murine human macrophages pre-treatment mix these (Cfr-LEO) reduces expression pro-inflammatory cytokines TNF-α, IL-1β, IL-6 induced by LPS. addition, Cfr-LEO counteracts LPS-induced oxidative stress, as shown increase GSH/GSSG ratio comparison to cells treated LPS alone....
Chronic inflammation is linked to the development of numerous diseases and accompanied by increased cytokine secretion. Macrophages provide a first line defense against pathogens that under inflammatory stimuli release pro-inflammatory cytokines. The essential oil (EO) fractions obtained from Citrus spp. rich in different compounds have gained attention both researchers users during last decades. In particular, grapefruit (Citrus paradisi) peel phenolics flavonoids with several health...
Lemon essential oil (LEO) is known for its aromatic and healthy properties; however, less consideration given to the biological properties of fractions obtained from LEO. This study aims evaluate ability a citral-enriched fraction LEO (Cfr-LEO) counteract lipopolysaccharide (LPS)-mediated inflammation, oxidative stress, epithelial-mesenchymal transition (EMT) in human hepatocytes. Human immortalized hepatocytes (THLE-2 cell line) were pretreated with Cfr-LEO subsequently exposed LPS at...