A5029910163- Inflammasome and immune disorders
- Olfactory and Sensory Function Studies
- Advanced Chemical Sensor Technologies
- Long-Term Effects of COVID-19
- Immunodeficiency and Autoimmune Disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Blood groups and transfusion
- IgG4-Related and Inflammatory Diseases
- Biochemical Analysis and Sensing Techniques
- COVID-19 Clinical Research Studies
- Neuroendocrine Tumor Research Advances
- Allergic Rhinitis and Sensitization
- Platelet Disorders and Treatments
University Hospital Carl Gustav Carus
2022-2023
TU Dresden
2022-2023
Charité - Universitätsmedizin Berlin
2014
Abstract In the aftermath of COVID-19 pandemic, we are witnessing an unprecedented wave post-infectious complications. Most prominently, millions patients with Long-Covid complain about chronic fatigue and severe post-exertional malaise. Therapeutic apheresis has been suggested as efficient treatment option for alleviating mitigating symptoms in this desperate group patients. However, little is known mechanisms biomarkers correlating outcomes. Here, have analyzed different cohorts specific...
The aim of this study was to investigate whether COVID-associated olfactory impairment differs from disorders due other upper respiratory tract infections. We investigated the frequency a SARS-CoV-2 infection among subjects presenting with subjective corona outpatient clinic between October 2020 and March 2021. Olfactory gustatory loss were tested psychophysically, type infection, versus 14 common cold viruses, assessed nasopharyngeal swabs. Differences smell caused by pathogens compared....
Abstract Purpose This study aimed to evaluate the course of olfactory dysfunction [OD] due upper respiratory tract infections [URTI] especially for COVID-19 [C19] in a multicentric design and investigate possible predictors outcome. Methods In study, patients ( n = 147, which 96 were women) with OD URTI, including C19 non-C19 evaluated at two visits standardized medical history “Sniffin’ Sticks” extended psychophysical testing examine improvement function. Results showed better overall...
Abstract Genetic defects in the interferon (IFN) system or neutralizing autoantibodies against type I IFNs contribute to severe COVID-19. Such were proposed affect post–COVID-19 syndrome (PCS), possibly causing persistent fatigue for >12 weeks after confirmed SARS-CoV-2 infection. In current study, we investigated 128 patients with PCS, 21 survivors of COVID-19, and 38 individuals who asymptomatic. We checked IFN-α, IFN-β, IFN-ω. Few PCS had but no activity, indicating a limited role...
<b><i>Background:</i></b> In general, patients with significant anti-Ig-A do not tolerate intravenous (i.v.) administration of normal blood products. Here, we present our experiences in the induction immune tolerance (IIT) and long-term treatment a series such affected way. The question whether components from IgA-deficient donors are required will be discussed. <b><i>Methods: </i></b>Ten adult (4 females 6 males; age ranging 36 to 75 years)...
Abstract Recently, unexpectedly high virus-specific IgG4 levels were reported after more than two mRNA vaccinations. Class switch towards occurs long-term antigen exposure, downregulates immune responses and is associated with several autoimmune diseases. Here, we examined differences in antigen-specific IgG subtypes serum samples from 64 Post-COVID patients an equally sized cohort of convalescent controls. In both cohorts, the relative amounts spike protein-specific comparable. IgG1 was...