A5013327790- Pregnancy-related medical research
- Pregnancy and preeclampsia studies
- Circadian rhythm and melatonin
- Tryptophan and brain disorders
- Human Health and Disease
- Stress Responses and Cortisol
Deakin University
2021-2024
Relaxin-family peptide 3 receptor (RXFP3) is activated by relaxin-3 in the brain to influence arousal and related functions, such as feeding stress responses. Two transgenic mouse lines have recently been developed that co-express different fluorophores within RXFP3-expressing neurons: either yellow fluorescent protein (YFP; RXFP3-Cre/YFP mice) or tdTomato (RXFP3-Cre/tdTomato mice). To date, characteristics of neurons express RXFP3-associated these mice only investigated bed nucleus stria...
Patients with asthma experience elevated rates of mental illness. However, the molecular links underlying such lung-brain crosstalk remain ambiguous. Hypothalamic dysfunction is observed in many psychiatric disorders, particularly those an inflammatory component due to hypothalamic regions being unprotected by blood-brain barrier. To gain a better insight into neuropsychiatric sequelae, this study investigated gene expression differences hypothalamus following lung inflammation (asthma)...
RXFP3 (relaxin-family peptide 3 receptor) is the cognate G-protein-coupled receptor for neuropeptide, relaxin-3. expressed widely throughout brain, including hypothalamus, where it has been shown to modulate feeding behavior and neuroendocrine activity in rodents. In order better characterize its potential mechanisms of action, this study determined whether by dopaminergic neurons within arcuate nucleus (ARC) dorsomedial hypothalamus (DMH), addition ventral tegmental area (VTA). Neurons that...