A5103001089- Tryptophan and brain disorders
- Gut microbiota and health
- Barrier Structure and Function Studies
- Diet and metabolism studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Alzheimer's disease research and treatments
- Biochemical Acid Research Studies
- GDF15 and Related Biomarkers
- Sirtuins and Resveratrol in Medicine
- Hair Growth and Disorders
- Epigenetics and DNA Methylation
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Neurological Disease Mechanisms and Treatments
- Exercise and Physiological Responses
- Kruppel-like factors research
- Fibroblast Growth Factor Research
- Mitochondrial Function and Pathology
- Autophagy in Disease and Therapy
- Dietary Effects on Health
- Calcium signaling and nucleotide metabolism
Hunan Normal University
2023-2025
Jilin University
2023
Hair loss, or alopecia, is a prevalent condition in modern society that imposes substantial mental and psychological burden on individuals. The types of hair include androgenetic alopecia areata, telogen effluvium; them, the most common condition. Traditional treatment modalities mainly involve medical options, such as minoxidil, finasteride surgical interventions, transplantation. However, these treatments still have many limitations. Therefore, exploring pathogenesis specifically focusing...
A growing body of clinical data has shown that patients with Alzheimerâs disease (AD) have symptoms such as liver dysfunction and microbialâgutâbrain axis in addition to brain pathology, presenting a systemic multisystemic pathogenesis. Considering the benefits exercise, here, we first observed effects long-term treadmill exercise on injuries APP/PS1 transgenic AD mice explored potential mechanisms gutâliverâbrain axisâs role mediating exerciseâs ability reduce bacterial...
Abstract Aims Stroke is a devastating event and huge public health concern worldwide. Apremilast (APR) selective inhibitor of phosphodiesterase‐4 involved in various neurological diseases, including stroke. However, the protective effects APR on stroke have not been investigated. Here, we explored outcomes blood–brain barrier (BBB) dysfunction using middle cerebral artery occlusion (MCAO) mice model. Results The results show that attenuated injury MCAO with decreased deficit scores infarct...
Abstract Atherosclerosis is a common disease typically associated with the dysregulation of inflammatory pathways and lipid metabolism. Regular exercise can prevent delay atherosclerosis-related dysfunctions; however effects different types on atherosclerosis their underlying molecular mechanisms remain unclear. Based evidence intestinal microbiota dysbiosis impaired intestine-liver-brain axis in APOE-knockout (KO) mice, we found plasma profile abnormalities, imbalance, inflammation, liver...
Alzheimer’s disease (AD) causes a decline in skeletal muscle function, which can further exacerbate the cognitive dysfunction of patients with AD. It has been widely established that exercise improves AD brain pathology, but role is still poorly understood. In this study, we investigated effects treadmill on ability APP/PS1 transgenic mice and explored potential gene expression changes their muscle. The were subjected to for 12 weeks, followed by Morris water maze open field test. After...
Background/Purpose: The gut-brain axis is the communication mechanism between gut and central nervous system, intestinal flora lipopolysaccharide (LPS) play a crucial role in this mechanism. Exercise regulates microbiota composition metabolite (i.e., LPS) production. We aimed to investigate effects of moderate-intensity continuous training high-intensity interval (HIIT) on cognitive function C57BL/6J mice through regulation LPS displacement. Method: male were randomly assigned into quiet...