A5002232583- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Cell Adhesion Molecules Research
- Nanoplatforms for cancer theranostics
- MXene and MAX Phase Materials
- Dermatological and COVID-19 studies
- Medical Imaging and Pathology Studies
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Advancements in Transdermal Drug Delivery
University of Michigan
2023
Binghamton University
2019-2021
Extracellular vesicles (EVs) are lipid-bilayer-enclosed of submicron size that secreted by various cells. As mediators intercellular communication, EVs can alter the physiological state recipient cells delivering encapsulated proteins and nucleic acids. Incontestably, growing evidence has shown important biological roles clinical relevance EVs. The use stem cell-derived as a cell-free therapeutic modality for skin treatment emerged promising application in dermatology. However, moderate...
Extracellular vesicles (EVs) are cell-released of submicrometer size. EVs contain a tissue-specific signature wherein variety proteins and nucleic acids selectively packaged. Recent studies validate that can be used for cancer diagnostics, staging, treatment monitoring. EV-related clinical translation requires effective EV isolation as prerequisite. However, lengthy procedures, low yield, throughput, high levels contaminants disqualify the existing approaches large-scale use. Hence, new...
Cancer derived extracellular vesicles can be specifically and efficiently isolated by multivalent aptamers which are prepared rolling cycle amplification for downstream molecular analyses.
Direct measurement of the small extracellular vesicle in cell culture supernatant.
Extracellular vesicle (EV) secretion has been observed in many types of both normal and tumor cells. EVs contain a variety distinctive cargoes, allowing tumor-derived serum proteins to act as minimally invasive method for clinical monitoring. We have undertaken comprehensive study the protein content from several cancer cell lines using direct data-independent analysis. Several thousand were detected, including classic EV markers such CD9, CD81, CD63, TSG101, Syndecan-1, among others....