A5086066278- Antibiotic Resistance in Bacteria
- Vibrio bacteria research studies
- Escherichia coli research studies
- Pneumonia and Respiratory Infections
- Bacterial biofilms and quorum sensing
- Enterobacteriaceae and Cronobacter Research
- Environmental Toxicology and Ecotoxicology
- Antibiotic Use and Resistance
- Pharmaceutical and Antibiotic Environmental Impacts
- Inflammatory mediators and NSAID effects
- Metabolomics and Mass Spectrometry Studies
- Tuberculosis Research and Epidemiology
- Pesticide and Herbicide Environmental Studies
- Ionic liquids properties and applications
- Pharmacogenetics and Drug Metabolism
- Electrochemical Analysis and Applications
- Antimicrobial Resistance in Staphylococcus
- Analytical chemistry methods development
- Burkholderia infections and melioidosis
- Salmonella and Campylobacter epidemiology
- Antibiotics Pharmacokinetics and Efficacy
- PI3K/AKT/mTOR signaling in cancer
Dublin City University
2023
University of Naples Federico II
2009-2015
Federico II University Hospital
2012-2015
Ceinge Biotecnologie Avanzate (Italy)
2009
Abstract Background Acinetobacter baumannii is responsible for large epidemics in hospitals, where it can persist long time on abiotic surfaces. This study investigated some virulence-related traits of epidemic A. strains assigned to distinct MLST genotypes, including those corresponding the international clones I-III as well emerging genotypes recent epidemics. Methods Genotyping bacteria was performed by PFGE analysis and according Pasteur’s scheme. Biofilm formation polystyrene plates...
Acinetobacter baumannii is an opportunistic pathogen responsible for hospital-acquired infections. A. epidemics described world-wide were caused by few genotypic clusters of strains. The occurrence multi-drug resistant strains assigned to novel genotypes have been reported over the last years.In present study, we compared whole genome sequences three ST2, ST25 and ST78, representative most frequent in several Mediterranean hospitals, four complete ST1, ST2 ST77. Comparative analysis showed...
Single-locus blaOXA-51-like sequence-based typing (SBT) was evaluated for its ability to determine correctly sequence types (STs) in Acinetobacter baumannii clinical isolates, comparison with the Pasteur's multilocus (MLST) reference method and 3-locus (3-LST). The comparative study performed 585 multidrug-resistant (MDR) A. isolates recovered from 21 hospitals located throughout Greece, Italy, Lebanon, Turkey. belonged nine clonal complexes (CCs) that correspond 12 distinct one singleton...
PGE2 plays a critical role in colorectal carcinogenesis. We have previously shown that COX-2 expression and synthesis are mediated by IGF-II/IGF-I receptor signaling the Caco-2 cell line pathway of phosphatidylinositol 3-kinase (PI3K)/Akt protects from apoptosis. In present study, we demonstrate has ability to increase Ras PI3K association decrease level apoptosis same experimental system. The effect on PI3K/Ras is dependent activation EP4 receptor, cAMP levels, PKA. fact, treatment cells...
ABSTRACT The molecular epidemiology of multidrug-resistant Acinetobacter baumannii was investigated in two intensive care units the V. Monaldi university hospital Naples, Italy, from May 2006 to December 2007. Genotype analysis by pulsed-field gel electrophoresis (PFGE), trilocus sequence-based typing (3LST), and multilocus sequence (MLST) A. isolates 71 patients identified distinct genotypes, one assigned PFGE group A, 3LST 1, ST2 14 other B, 6, ST78 patients, that we named ST2/A ST78/B,...
ObjectivesTo analyse the evolution and genetic relatedness of Acinetobacter baumannii clonal lineages in Greece during a 10 year period.
Ionic liquids have been described as green solvents, however, their presence in the aquatic environment may indicate a threat for key species. Focusing on freshwater ecosystem, five ionic containing 1-butyl-3-methylimidazolium (BMIM) cation were compared acute toxicity and chronic responses daphnids. Biochemical markers of physiology including activity phosphatases, β-galactosidase, peptidase, lipase glutathione-S-transferase used to assess changes Feeding reproduction investigated surrogate...
ABSTRACT Acinetobacter baumannii is an emerging opportunistic Gram-negative pathogen responsible for hospital-acquired infections. A. epidemics described in Europe and worldwide were caused by a limited number of genotypic clusters multidrug-resistant strains. Here, we report the availability draft genome sequences three strains assigned to multilocus sequence typing genotypes ST2, ST25, ST78 that more frequently isolated during outbreaks occurred Greece, Italy, Lebanon, Turkey.
The toxicological hazard and safety assessment of chemical substances relies on the outcome animal testing involving phenotypic tests such as feeding.
The assessment of pollution is a serious issue and major consequence the overgrowing human population its activities. Focusing on aquatic ecosystem, traditional approaches water chemistry mainly provide minimal monitoring with detection pollutants, while they fail to produce mechanistic or predictive insight. As such, effect-based methods have gained significant attention for better understanding pollution. Among key species used, daphnids acquired central position in toxicology ecology. In...