A5057998269- Antibiotic Resistance in Bacteria
- Vibrio bacteria research studies
- Helicobacter pylori-related gastroenterology studies
- Bacterial biofilms and quorum sensing
- Galectins and Cancer Biology
- Antibiotics Pharmacokinetics and Efficacy
- Escherichia coli research studies
- Growth Hormone and Insulin-like Growth Factors
- Pneumonia and Respiratory Infections
- Eosinophilic Esophagitis
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Gastric Cancer Management and Outcomes
- Enterobacteriaceae and Cronobacter Research
- Inflammatory mediators and NSAID effects
- Infections and bacterial resistance
- Pharmaceutical and Antibiotic Environmental Impacts
- Genetic Syndromes and Imprinting
- Neonatal and Maternal Infections
- Plant Pathogenic Bacteria Studies
- PI3K/AKT/mTOR signaling in cancer
- Urinary Tract Infections Management
- Metabolism, Diabetes, and Cancer
- RNA modifications and cancer
- Genetic factors in colorectal cancer
University of Naples Federico II
2016-2025
Federico II University Hospital
2007-2023
Ceinge Biotecnologie Avanzate (Italy)
2007-2017
Italian Society of Physiotherapy
2015
Bentham Science Publishers (United Arab Emirates)
2012
Bentham Science Publishers (China)
2012
Istituto Nazionale di Fisica Nucleare, Sezione di Napoli
2006
General Department of Preventive Medicine
2004
Chiron (Norway)
2004
Institute for Experimental Endocrinology and Oncology
1990-2003
Background. Extensively drug-resistant (XDR) Acinetobacter baumannii may cause serious infections in critically ill patients. Colistin often remains the only therapeutic option. Addition of rifampicin to colistin be synergistic vitro. In this study, we assessed whether combination and reduced mortality XDR A. compared alone.
Abstract Helicobacter pylori (Hp)-associated gastritis is characterized by an increased number of acute and chronic inflammatory cells secreting cytokines that contribute to maintain expand the local inflammation. Locally induced IL-8 believed play a major role in Hp-associated response. Factors/mechanisms regulate induction are, however, not fully understood. In present study we investigated whether Hp infection associated with production IL-17, T cell-derived cytokine capable modulating...
Abstract Background Acinetobacter baumannii is responsible for large epidemics in hospitals, where it can persist long time on abiotic surfaces. This study investigated some virulence-related traits of epidemic A. strains assigned to distinct MLST genotypes, including those corresponding the international clones I-III as well emerging genotypes recent epidemics. Methods Genotyping bacteria was performed by PFGE analysis and according Pasteur’s scheme. Biofilm formation polystyrene plates...
Acinetobacter species assigned to the calcoaceticus-baumannii (Acb) complex, are Gram-negative bacteria responsible for a large number of human infections. The population structure Acb has been studied using two 7-gene MLST schemes, introduced by Bartual and coworkers (Oxford scheme) Diancourt (Pasteur scheme). schemes have three genes in common but underlie coexisting nomenclatures sequence types clonal complexes, which complicates communication on A. baumannii genotypes. aim this study was...
The global dissemination of Klebsiella pneumoniae and carbapenemase (KPC) has been largely attributed to a few high-risk sequence types (STs) (ST258, ST11, ST512) associated with human disease. ST101 is an emerging clone that identified in different parts the world potential become global, persistent public health threat. Recent research suggests lineage 11% increase mortality rate comparison non-ST101 infections. In this study, we generated high-quality, near-finished genome assembly...
<i>Helicobacter pylori</i> has been suggested to play a role in the development of gastric carcinoma humans. Also, mounting evidence indicates that cyclooxygenase-2 overexpression is associated with gastrointestinal carcinogenesis. We studied effect <i>H. on expression and activity cyclooxygenase-1 MKN 28 mucosal cells. did not affect expression, whereas mRNA levels increased by 5-fold at 24 h after incubation cells broth culture filtrates or bacterial suspensions from wild-type...
ABSTRACT The molecular epidemiology of multidrug-resistant Acinetobacter baumannii was investigated in the medical-surgical intensive care unit (ICU) a university hospital Italy during two window periods which sequential A. epidemics occurred. Genotype analysis by pulsed-field gel electrophoresis (PFGE) isolates from 131 patients identified nine distinct PFGE patterns. Of these, clones B and I predominated occurred sequentially epidemics. epidemic showed antibiotype, being clone resistant to...
Acinetobacter baumannii is an opportunistic pathogen responsible for hospital-acquired infections. A. epidemics described world-wide were caused by few genotypic clusters of strains. The occurrence multi-drug resistant strains assigned to novel genotypes have been reported over the last years.In present study, we compared whole genome sequences three ST2, ST25 and ST78, representative most frequent in several Mediterranean hospitals, four complete ST1, ST2 ST77. Comparative analysis showed...
A giant protein called BAP (biofilm-associated protein) plays a role in biofilm formation and adhesion to host cells A. baumannii. Most of the is made by arrays 80–110 aa modules featuring immunoglobulin-like (Ig-like) motifs. The survey 541 baumannii sequenced strains belonging 108 STs (sequence types) revealed that highly polymorphic, distinguishable three main types for changes both repetitive COOH region. Analyzing different STs, we found 29 % feature type-1, 40 type-2 BAP, 11 type-3 20...
The spread of carbapenem resistant Enterobacteriaceae (CRE) is an emerging clinical problem, great relevance in Europe and worldwide. aim this study was the molecular epidemiology CRE isolates Valle d'Aosta region, Italy, mechanism resistance.Sixty consecutive samples were isolated from 52 hospital inpatients and/or outpatients November 2013 to August 2014. Genotyping microbial done by pulsed-field gel electrophoresis (PFGE) multi-locus sequence typing (MLST), carbapenemases identified PCR...
Acinetobacter baumannii is a globally distributed nosocomial pathogen that has gained interest due to its resistance most currently used antimicrobials. Whole genome sequencing (WGS) and phylogenetics begun reveal the global genetic diversity of this pathogen. The evolution A. largely been defined by recombination, punctuated emergence proliferation clonal lineages. In study we sequenced seven genomes from sequence type (ST)25 lineage compared them 12 ST25 deposited in public databases. A...
Single-locus blaOXA-51-like sequence-based typing (SBT) was evaluated for its ability to determine correctly sequence types (STs) in Acinetobacter baumannii clinical isolates, comparison with the Pasteur's multilocus (MLST) reference method and 3-locus (3-LST). The comparative study performed 585 multidrug-resistant (MDR) A. isolates recovered from 21 hospitals located throughout Greece, Italy, Lebanon, Turkey. belonged nine clonal complexes (CCs) that correspond 12 distinct one singleton...
Resistance to colistin is increasingly reported in Klebsiella pneumoniae clinical isolates. The aim of this study was analyze the molecular epidemiology and virulence profiles 25 colistin-resistant K. blood isolates from Hospital Agency "Ospedale dei Colli," Naples, Italy, during 2015 2016. Colistin MIC values ranged 4 256 mg/L. inactivation mgrB gene, encoding a negative regulator PhoQ/PhoP signaling system, most frequent mechanism resistance found 22 out Of these, 10 assigned ST512 PFGE...
Helicobacter pylori infection is associated with inflammation of the gastric mucosa and mucosal damage. In this study, we sought to test hypothesis that two H. virulence factors (VacA CagA) impair epithelial cell migration proliferation, main processes involved in healing vivo. Human cells (MKN 28) were incubated undialyzed or dialyzed broth culture filtrates from wild-type strains isogenic mutants defective production VacA, CagA, both products. We found (i) VacA specifically inhibited...