A5010206684- Environmental Toxicology and Ecotoxicology
- Pharmaceutical and Antibiotic Environmental Impacts
- Nanoparticles: synthesis and applications
- Microplastics and Plastic Pollution
- Pesticide and Herbicide Environmental Studies
- Planetary Science and Exploration
- Metabolomics and Mass Spectrometry Studies
- Heavy Metal Exposure and Toxicity
- Polar Research and Ecology
- Advanced Biosensing Techniques and Applications
- Advanced Proteomics Techniques and Applications
- Mycotoxins in Agriculture and Food
- Glutathione Transferases and Polymorphisms
- DNA Repair Mechanisms
- Free Radicals and Antioxidants
- Meat and Animal Product Quality
- bioluminescence and chemiluminescence research
- Sulfur Compounds in Biology
- Antioxidant Activity and Oxidative Stress
- Trace Elements in Health
- Electron Spin Resonance Studies
- Ionic liquids properties and applications
- Nitric Oxide and Endothelin Effects
- Folate and B Vitamins Research
- Redox biology and oxidative stress
Dublin City University
2018-2024
University of Patras
2008-2022
University of Birmingham
2016-2019
UCLouvain
2015-2017
Foundation for Research and Technology Hellas
2014
Institut thématique Génétique, génomique et bioinformatique
2009
The combination of intense solar radiation and soil desiccation creates a short circuit in the biogeochemical carbon cycle, where soils release significant amounts CO2 reactive nitrogen oxides by abiotic oxidation. Here we show that desert accumulate metal superoxides peroxides at higher levels than non-desert soils. We also photogeneration equimolar superoxide hydroxyl radical desiccated aqueous soils, respectively, photo-induced electron transfer mechanism supported their mineralogical...
We show here that oxidative stress is involved in both sclerotial differentiation (SD) and aflatoxin B1 biosynthesis Aspergillus flavus. Specifically, we observed (i) regulates SD, as implied by its inhibition antioxidant modulators of reactive oxygen species thiol redox state, (ii) SD are comodulated stress. However, inhibited lower levels compared to shown comparison undifferentiated A. These same also characterize a mutant flavus strain, lacking the global regulatory gene veA. This unable...
Pharmaceuticals pose a great threat to organisms inhabiting the aquatic environment. Non-steroidal anti-inflammatory drugs (NSAIDs) are major pharmaceutical pollutants with significant presence in freshwater ecosystems. In this study, impact of indomethacin and ibuprofen, two most commonly prescribed NSAIDs, was assessed on Daphnia magna. Toxicity as immobilization animals used determine non-lethal exposure concentrations. Feeding phenotypic endpoint key enzymes were molecular endpoints...
Pharmaceuticals have been classified as emerging contaminants in the aquatic ecosystem, mainly due to their increased use and improper disposal. A significant range of pharmaceutical compounds metabolites globally detected surface waters pose detrimental effects non-target organisms. Monitoring water pollution relies on analytical approaches for detection, however, such are limited by sensitivity limit coverage wide compounds. This lack realism risk assessment is bypassed with effect-based...
Traditional approaches for monitoring aquatic pollution primarily rely on chemical analysis and the detection of pollutants in aqueous environments. However, these methods lack realism mechanistic insight and, thus, are increasingly supported by effect-based methods, which offer sensitive endpoints. In this context, daphnids, a freshwater species used extensively molecular ecotoxicology, fast noninvasive to assess impact pollutants. Among phenotypic endpoints used, feeding rate is highly...
Protein coronas on nanoparticles (NPs) affect their physicochemical properties, cellular uptake, and toxicity, have been described extensively. To date, studies of the occurrence small molecule (metabolite) are limited. We sought to determine whether a metabolite corona forms NPs, using high-sensitivity metabolomics combined with model system for freshwater ecotoxicology (Daphnia magna feeding Chlorella vulgaris). Using amino-functionalized polystyrene NPs (NH2-pNPs), we showed impact this...
The continuous global increase in population and consumption of resources due to human activities has had a significant impact on the environment. Therefore, assessment environmental exposure toxic chemicals as well their biological systems is importance. Freshwater are currently under threat monitored; however, current methods for pollution can neither provide mechanistic insight nor predict adverse effects from complex pollution. Using daphnids bioindicator, we assessed acute exposures...
Ionic liquids have been described as green solvents, however, their presence in the aquatic environment may indicate a threat for key species. Focusing on freshwater ecosystem, five ionic containing 1-butyl-3-methylimidazolium (BMIM) cation were compared acute toxicity and chronic responses daphnids. Biochemical markers of physiology including activity phosphatases, β-galactosidase, peptidase, lipase glutathione-S-transferase used to assess changes Feeding reproduction investigated surrogate...
Pharmaceutical compounds are among several classes of contaminants emerging concern, such as pesticides, heavy metals and personal care products, all which a major concern for aquatic ecosystems. The hazards posed by the presence pharmaceutical is one affects both freshwater organisms human health-via non-target effects contamination drinking water sources. molecular phenotypic alterations five pharmaceuticals commonly present in environment were explored daphnids under chronic exposures....
Food spoilage is an ongoing global issue that contributes to rising carbon dioxide emissions and increased demand for food processing. This work developed anti-bacterial coatings utilising inkjet printing of silver nano-inks onto food-grade polymer packaging, with the potential enhance safety reduce spoilage. Silver were synthesised via laser ablation synthesis in solution (LaSiS) ultrasound pyrolysis (USP). The nanoparticles (AgNPs) produced using LaSiS USP characterised transmission...
Plastic waste is considered a major threat for terrestrial, marine and freshwater ecosystems. Ingestion of primary or secondary microparticles resulting from plastic degradation can lead to their trophic transfer raising serious health concerns. In this study, the effect amine carboxy functionalized polystyrene on physiology daphnids was investigated with combination phenotypic metabolic endpoints. Carboxy showed higher toxicity in acute exposures compared counterparts. Accumulation both...
Oxidative stress seems to be a cardinal feature of cholestasis, implicated in the pathophysiology organ injury not only liver, but also several extrahepatic tissues. The present study was designed assess directly oxidative vital organs experimentally jaundiced rats by measuring key marker superoxide radical (O2(*-)). Twelve male Wistar underwent laparotomy and were divided into two groups - group I (n = 6) sham operated, II bile-duct ligated. Ten days later, O2(*-) formation rate quantified...