A5089935456- Photochromic and Fluorescence Chemistry
- Conducting polymers and applications
- EEG and Brain-Computer Interfaces
- Neuroscience and Neural Engineering
- Neuroscience and Neuropharmacology Research
- Cognitive Science and Education Research
- Photoacoustic and Ultrasonic Imaging
- Receptor Mechanisms and Signaling
- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Electrochemical Analysis and Applications
Institute of Automation
2023
University of Chinese Academy of Sciences
2023
Columbia University
2018-2022
Masaryk University
2018
Hamamatsu University School of Medicine
2018
Voltage sensitive fluorescent dyes (VSDs) are important tools for probing signal transduction in neurons and other excitable cells. The impact of these highly lipophilic sensors has, however, been limited due to the lack cell-specific targeting methods brain tissue or living animals. We address this key challenge by introducing a nongenetic molecular platform cell- molecule-specific synthetic VSDs brain. employ dextran polymer particle overcome inherent lipophilicity dynamic encapsulation...
Decoding non-invasive brain recordings is crucial for advancing our understanding of human cognition, yet faces challenges from individual differences and complex neural signal representations. Traditional methods require custom models extensive trials, lack interpretability in visual reconstruction tasks. Our framework integrating integrates 3D structures with semantics by Vision Transformer 3D. The unified feature extractor aligns fMRI features multiple levels embeddings efficiently,...
Optical imaging of changes in the membrane potential living cells can be achieved by means fluorescent voltage-sensitive dyes (VSDs). A particularly challenging task is to efficiently deliver these highly lipophilic probes specific neuronal subpopulations brain tissue. We have tackled this designing a solubilizing, hydrophilic polymer platform that carries high-affinity ligand for protein marker interest and VSD. Here, we disclose an improved design polymer-supported chemical, nongenetic...
Clarifying the mechanisms of loss and recovery consciousness in brain is a major challenge neuroscience, research on spatiotemporal organization rhythms at region scale different levels remains scarce. By applying computational an extended corticothalamic network model was developed this study to simulate altered states induced by concentration propofol. The cortex area containing oscillation spread from posterior anterior four successive time stages, defining groups regions. A quantitative...
Voltage sensitive fluorescent dyes (VSDs) are important tools for probing signal transduction in neurons and other excitable cells. These sensors, rendered highly lipophilic to anchor the conjugated p-wire molecular framework membrane, offer several favorable functional parameters including fast response kinetics high sensitivity membrane potential changes. The impact of VSDs has however been limited due lack cell-specific targeting methods brain tissue or living animals. We address this key...
Optical imaging of changes in membrane potential living cells can be achieved by the means fluorescent voltage sensitive dyes (VSDs). A particularly challenging task is to efficiently deliver these highly lipophilic probes specific neuronal subpopulations brain tissue. We have tackled this designing a solubilizing, hydrophilic polymer platform that carries high-affinity ligand for protein marker interest and VSD. Here, we disclose an improved design supported chemical, non-genetic targeting...