A5059231453- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Neuroblastoma Research and Treatments
- Uterine Myomas and Treatments
- Chemokine receptors and signaling
- Pancreatic and Hepatic Oncology Research
- Hepatitis C virus research
- Endometriosis Research and Treatment
- Liver Disease and Transplantation
- Endometrial and Cervical Cancer Treatments
- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- Liver Disease Diagnosis and Treatment
University of Bern
2022-2025
Università Cattolica del Sacro Cuore
2019-2022
Porto-sinusoidal vascular disorder (PSVD) is a group of liver diseases featuring lesions encompassing the portal venules and sinusoids unaccompanied by cirrhosis, irrespective presence/absence hypertension. It can occur secondary to coagulation disorders or insult toxic agents. However, cause PSVD remains unknown in most cases. Hereditary cases are exceptionally rare, but they particular interest may unveil genetic alterations molecular mechanisms associated with disease.We performed genome...
Benign metastasizing leiomyoma (BML) is a rare disease with an unknown etiopathogenesis that mostly affects middle-aged women uterine leiomyoma. Many metastatic nodules outside the uterus characterize condition. The metastases are smooth muscle lesions without malignancy. Morphologically and immunohistochemically, they resemble leiomyomas, indicating shared clonal origin. lungs most prevalent site for incidental metastasis detection. BML has relatively slow progression good prognosis,...
Triple-negative breast cancer (TNBC) accounts for ~15-20% of (BC) and has a higher rate early relapse mortality compared to other subtypes. The Chemokine (C-C motif) ligand 5 (CCL5) its signaling pathway have been linked TNBC. We aimed investigate the susceptibility prognostic implications genetic variation in CCL5 genes TNBC present study. characterized variants that six (CCND1, ZMIZ1, CASP8, NOTCH2, MAP3K21, HS6ST3) among 1,082 unrelated Tunisian subjects (544 BC patients, including 196...
Traditionally considered non-functional low proliferative benign neuroendocrine proliferations measuring less than 5 mm, pancreatic (neuro)endocrine microadenomas are now classified as microtumors in the 2022 WHO classification of endocrine and tumors. This case report discussed features an incidentally identified 4.7-mm glucagon-expressing microtumor with MEN1 mutation only, chromosomally stable epigenetic alpha-like phenotype. The tumor was associated unexplained increased proliferation...
Abstract There are no therapeutic predictive biomarkers or representative preclinical models for high-grade gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN), a highly aggressive, fatal, and heterogeneous malignancy. We established patient-derived (PD) tumoroids from biobanked tissue samples of advanced GEP-NEN patients applied this model targeted rapid ex vivo pharmacotyping, next-generation sequencing, perturbational profiling. used tissue-matched PD to profile individual patients,...
ABSTRACT There are no therapeutic predictive biomarkers or representative preclinical models for high-grade gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN), a highly aggressive, fatal, and heterogeneous epithelial malignancy. We established patient-derived (PD) tumoroids from biobanked tissue samples of advanced GEP-NEN patients applied this model targeted rapid ex vivo pharmacotyping, next-generation sequencing, perturbational profiling. used tissue-matched PD to profile...