A5043935378- Advanced Numerical Analysis Techniques
- Mathematical Biology Tumor Growth
- CAR-T cell therapy research
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- HIV Research and Treatment
- Career Development and Diversity
- Mathematical and Theoretical Epidemiology and Ecology Models
- Herpesvirus Infections and Treatments
- COVID-19 epidemiological studies
- Monoclonal and Polyclonal Antibodies Research
- Virus-based gene therapy research
- Cancer Genomics and Diagnostics
- 3D Shape Modeling and Analysis
- Digital Image Processing Techniques
- Composite Structure Analysis and Optimization
- Cancer Immunotherapy and Biomarkers
- Phagocytosis and Immune Regulation
- SARS-CoV-2 and COVID-19 Research
- Cellular Mechanics and Interactions
- COVID-19 Pandemic Impacts
- Blood groups and transfusion
- Pancreatic and Hepatic Oncology Research
- Blood transfusion and management
- Adult and Continuing Education Topics
Frederick National Laboratory for Cancer Research
2024-2025
St. Mary's College of Maryland
2013-2024
Saint Mary's College
2017
Eskişehir City Hospital
2015
Drexel University
2006
The rebound competent viral reservoir (RCVR)–virus that persists during antiretroviral treatment (ART) and can reignite systemic infection when is stopped–is the primary barrier to eradicating HIV. We used time initiation of ART rhesus macaques (RMs) after intravenous challenge with barcoded SIVmac239 as a means elucidate dynamics RCVR establishment in groups RMs by creating multi-log range pre-ART loads then assessed time-to-rebound reactivation rates resulting from discontinuation one...
T cell immunotherapy success is dependent on effective levels of antigen receptor expressed at the surface engineered cells. Efforts to optimize expression in (TCR)-based therapeutic approaches include optimization cellular engineering methods and coding sequences, reducing likelihood exogenous TCR α β chains mispairing with endogenous chains. Approaches promote correct human chain pairing constant region mutations create an additional disulfide bond between two chains, full murinization a...
An alternative to lifelong antiretroviral therapy (ART) is needed achieve durable control of HIV-1. Here, we show that adeno-associated virus (AAV) delivery two rhesus macaque antibodies the simian immunodeficiency (SIV) envelope glycoprotein (Env) with potent neutralization and antibody-dependent cellular cytotoxicity can prevent viral rebound in macaques infected barcoded SIV mac 239M after discontinuing suppressive ART. After AAV administration, sustained antibody expression minimal...
The main drawback of the Frenet frame is that it undefined at those points where curvature zero. Furthermore, in case planar curves, does not agree with standard framing curves plane. Bishop principle normal vector N it. Our new frame, which we call Beta combines, on a large set best aspects frames and frames. It yields globally defined normal, signed curvature, torsion. For agrees
We propose a mathematical model to describe the interaction of cancer stem cells, tumor and immune system in order better understand growth presence cells. consider two scenarios: with no-treatment chemotherapy treatment regimen. develop differential equations, fit parameters experimental data, perform sensitivity stability analysis. The simulations show that cells grow as predicted chemotherapy, which targets only will eventually relapse. As does not target we conclude recover due
We compute a family of double-mirror catadioptric sensors with ultrawide field view and no distortion. The two concentric mirrors are rotationally symmetric, the inside mirror is revolved conic section. mapping between object image planes was linear, hence lack equations describing outer were determined by projection induced rectifying property sensor. Solving resulting nonlinear ordinary differential yielded cross section secondary mirror. we present require further digital processing.
Therapeutic vaccines play a large role in the cast of immunotherapies that are now an essential component most cancer treatment regimes. The complexity immune response and ability tumour to mount counter-offensive this have made it difficult predict who will respond what treatments, for clinicians optimise strategies individual patients. In paper, we present mathematical model captures dynamics adaptive autologous whole-cell vaccine, without some complexities previous models incorporate...
Therapeutic vaccines play a large role in the cast of immunotherapies that are now an essential component most cancer treatment regimes. The complexity immune response and ability tumour to mount counter-offensive this have made it difficult predict who will respond what treatments, for clinicians optimise strategies individual patients. In paper, we present mathematical model captures dynamics adaptive autologous whole-cell vaccine, without some complexities previous models incorporate...
In this article, we present a case study of course called Women in Mathematics. Students the studied lives and mathematical contributions women mathematicians throughout history, as well current gender equity issues mathematics careers. They also mentored 20 middle school girls semester. This nested strategy (with professor providing an environment where college students could appreciate math, they, turn, creating same for girls) resulted improvements both students' girls' attitudes towards...
In this paper, we introduce a SEIR-type COVID-19 model where the infected class is further divided into subclasses with individuals in intensive care (ICUs) and ventilation units. The calibrated symptomatic cases, deaths, number of patients ICUs units as reported by Republic Turkey, Ministry Health for period 11 March 2020 through 30 May when nationwide lockdown order. interventions Turkey are incorporated to detect future trend outbreak accurately. We tested effect underreporting found that...
Abstract An alternative to lifelong antiretroviral therapy (ART) is needed achieve durable control of HIV-1. Here we show that adeno-associated virus (AAV)-delivery two rhesus macaque antibodies the SIV envelope glycoprotein (Env) with potent neutralization and antibody-dependent cellular cytotoxicity can prevent viral rebound in macaques infected barcoded mac 239M after discontinuing suppressive ART. Following AAV administration, sustained antibody expression minimal anti-drug responses was...
SummaryStudents in college-level mathematics classes can build the differential equations of an energy balance model Earth's climate themselves, from a basic understanding background science. Here we use variable albedo and qualitative analysis to find stable unstable equilibria such model, providing problem or perhaps research project for students interested environmental studies mathematics.
Discretization of curves is an ancient topic. Even discretization with eye toward differential geometry over a century old. However there no general theory or methodology in the literature, despite ubiquitous use discrete mathematics and science. There are conflicting definitions even basic concepts such as curvature {\kappa}, torsion {\tau}, Frenet frame.
In this article we explore some finer properties of equi-areal mirrors and introduce techniques for developing new mirror surfaces that simultaneously minimize angular areal distortion.
Four women mathematicians at various stages of their careers public liberal arts institutions share struggles and challenges in professional personal lives during the pandemic.
Ideally, students of mathematics gain much from their coursework and undergraduate careers. If we (teachers professors) do our jobs right, then math majors minors should, among other achievements, the ability to apply mathematical knowledge disciplines real-world problems. Project-based learning offers one way achieve this goal, as it encourages solve interdisciplinary problems that arise outside traditional classroom. can be implemented part a class or an enrichment program, typically...
Of all cancers, pancreatic cancer has a significantly low rate of survival, mostly due to lack early screening. Thus, once detected, is usually in later stages, reducing the likelihood full recovery. The most common treatment strategy chemotherapy, although several immunotherapeutic drugs show promising results extending patient’s lifespan. In this paper, we provide validated mathematical model for after fitting parameter values, such as tumor growth rate, inverse carrying capacity,...
<p style='text-indent:20px;'>Dramatic strides have been made in treating human waste to remove pathogens and excess nutrients before discharge into the environment, benefit of ground surface water quality. Yet these advances undermined by dramatic growth Confined Animal Feeding Operations (CAFOs) which produce voluminous quantities untreated waste. Industrial swine routinely streams similar that a municipality, yet wastes are held open-pit "lagoons" at risk rupture or overflow. Eastern...
The Hsp70 family of molecular chaperones is necessary for protein folding, refolding misfolded client proteins, openness abnormal and can also inhibit programmed cell death <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> . A stressed a cancer cell. This stress frequently gives rise to cells have high levels Hsp70. In cancer, has been shown role in an anti-apoptotic capacity.