A5017533334- Influenza Virus Research Studies
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- Viral Infections and Outbreaks Research
- T-cell and B-cell Immunology
- RNA Research and Splicing
- Viral Infections and Immunology Research
- Blood disorders and treatments
- RNA and protein synthesis mechanisms
- Diabetes and associated disorders
- Chronic Lymphocytic Leukemia Research
National Institute of Allergy and Infectious Diseases
2022-2025
National Institutes of Health
2022-2025
Children's Hospital of Philadelphia
2025
University of Washington
2020
Current yearly seasonal influenza vaccines primarily induce an antibody response directed against the immunodominant but continually diversifying hemagglutinin (HA) head region. These responses provide protection vaccinating strain little cross-protection other strains or subtypes. To focus immune on subdominant more conserved epitopes HA stem that might protect a broad range of strains, we developed stabilized H1 immunogen lacking displayed ferritin nanoparticle (H1ssF). Here, evaluated B...
The conserved influenza hemagglutinin stem, which is a target of cross-neutralizing antibodies, now used in vaccine strategies focused on protecting against pandemics. Antibody responses to group 1 stem have been extensively characterized, but little known about 2. Here, we characterized the stem-specific repertoire individuals vaccinated with one three 2 subtypes (H3, H7, or H10). Epitope mapping revealed two epitope supersites stem. Antibodies targeting central were broadly cross-reactive,...
Influenza A virus subtype H2N2, which caused the 1957 influenza pandemic, remains a global threat. recent phase 1 clinical trial investigating ferritin nanoparticle vaccine displaying H2 hemagglutinin (HA) in H2-naive and H2-exposed adults enabled us to perform comprehensive structural biochemical characterization of immune memory on breadth diversity polyclonal serum antibody response elicited. We temporally map epitopes targeted by antibodies after prime boost, revealing that previous...
Summary Influenza A virus subtype H2N2, which caused the 1957 influenza pandemic, remains a global threat. recent phase I clinical trial investigating ferritin nanoparticle displaying H2 hemagglutinin in H2-naïve and H2-exposed adults. Therefore, we could perform comprehensive structural biochemical characterization of immune memory on breadth diversity polyclonal serum antibody response elicited after vaccination. We temporally map epitopes targeted by antibodies first second vaccinations...