A5018505322- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Respiratory Support and Mechanisms
- Nail Diseases and Treatments
- Non-Invasive Vital Sign Monitoring
- Telemedicine and Telehealth Implementation
- SARS-CoV-2 and COVID-19 Research
- Intensive Care Unit Cognitive Disorders
- COVID-19 diagnosis using AI
- IoT and Edge/Fog Computing
- Mobile Health and mHealth Applications
- Animal Virus Infections Studies
- COVID-19 and Mental Health
- Pediatric Pain Management Techniques
- Pneumothorax, Barotrauma, Emphysema
- Pneumocystis jirovecii pneumonia detection and treatment
- Family and Patient Care in Intensive Care Units
- Infectious Diseases and Mycology
- Viral Infections and Outbreaks Research
- Electrohydrodynamics and Fluid Dynamics
- Bacterial Infections and Vaccines
- Plant Virus Research Studies
- Plant Pathogens and Resistance
- Particle Dynamics in Fluid Flows
- Microfluidic and Bio-sensing Technologies
META Group
2025
Analysis Group (United States)
2025
Hospital for Tropical Diseases
2018-2024
Vietnam National University Ho Chi Minh City
2023
Hanoi University of Industry
2021
Talaromyces marneffei infection is a major cause of human immunodeficiency virus (HIV)-related death in South and Southeast Asia. Guidelines recommend initial treatment with amphotericin B deoxycholate, but this drug has substantial side effects, high cost, limited availability. Itraconazole available oral form, associated fewer unacceptable effects than amphotericin, widely used place amphotericin; however, clinical trials comparing these two treatments are lacking.In open-label,...
Cryptococcus neoformans (C. var. grubii) is an environmentally acquired pathogen causing 181,000 HIV-associated deaths each year. We sequenced 699 isolates, primarily C. from HIV-infected patients, 5 countries in Asia and Africa. The phylogeny of reveals a recent exponential population expansion, consistent with the increase number susceptible hosts. In our study population, this expansion has been driven by three sub-clades VNIa lineage; VNIa-4, VNIa-5 VNIa-93. These account for 91%...
Background: Cryptococcal meningitis has high mortality. Flucytosine is a key treatment but expensive and rarely available. The anticancer agent tamoxifen synergistic anti-cryptococcal activity with amphotericin in vitro. It off-patent, cheap, widely We performed trial to determine its therapeutic potential. Methods: Open label randomized controlled trial. Participants received standard care – combined fluconazole for the first 2 weeks or plus 300 mg/day. primary end point was Early...
Background: Cryptococcal meningitis is a leading cause of death in HIV-infected patients. International treatment guidelines recommend induction therapy with amphotericin B and flucytosine. This antifungal combination most effective, but unfortunately flucytosine expensive unavailable where the burden disease greatest. Where unavailable, fluconazole, this less mortality rates 40-50%. Faster clearance yeast from cerebrospinal fluid (CSF) are associated better outcomes - improving potency...
The CryptoDex trial showed that dexamethasone caused poorer clinical outcomes and slowed fungal clearance in human immunodeficiency virus-associated cryptococcal meningitis. We analyzed cerebrospinal fluid (CSF) cytokine concentrations from participants over the first week of treatment to investigate mechanisms harm test 2 hypotheses: (1) reduced proinflammatory concentrations, leading (2) leukotriene A4 hydrolase (LTA4H) genotype influenced impact dexamethasone, as observed tuberculous
We analyzed 1,303 SARS-CoV-2 whole-genome sequences from Vietnam, and found the Alpha Delta variants were responsible for a large nationwide outbreak of COVID-19 in 2021. The variant was confined to AY.57 lineage caused >1.7 million infections >32,000 deaths. Viral transmission strongly affected by nonpharmaceutical interventions.
Robust population pharmacokinetic (PK) data for fluconazole are scarce. The variability of penetration into the central nervous system (CNS) is not known.
<ns4:p>Background Awake prone positioning (APP) may be beneficial in patients with respiratory failure who are not receiving mechanical ventilation. Randomized controlled trials of APP have been performed during peak COVID-19 periods unvaccinated populations, limited data on compliance or patient acceptability. We aimed to evaluate the efficacy and acceptability a lower-middle income country an open-label randomized trial using dedicated implementation team wearable continuous-monitoring...
<ns3:p>Background Awake prone positioning (APP) may be beneficial in patients with respiratory failure who are not receiving mechanical ventilation. Randomized controlled trials of APP have been performed during peak COVID-19 periods unvaccinated populations, limited data on compliance or patient acceptability. We aimed to evaluate the efficacy and acceptability a lower-middle income country an open-label randomized trial using dedicated implementation team wearable continuous-monitoring...
<ns3:p>Evidence mainly from high income countries suggests that lying in the prone position may be beneficial patients with COVID-19 even if they are not receiving invasive ventilation. Studies indicate increased duration of associated improved outcomes, but achieving this requires additional staff time and resources. Our study aims to support prolonged (≥ 8hours/day) awake positioning moderate severe disease Vietnam. We use a specialist team wearable devices assist monitoring vital signs an...
<ns3:p>Patients with severe COVID-19 disease require monitoring pulse oximetry as a minimal requirement. In many low- and middle- income countries, this has been challenging due to lack of staff equipment. Wearable oximeters potentially offer an attractive means address need, their low cost, battery operability capacity for remote monitoring. Between July October 2021, Ho Chi Minh City experienced its first major wave SARS-CoV-2 infection, leading unprecedented demand in hospitalized...
Abstract Host non-T cell markers to aid in the diagnosis of cryptococcal meningoencephalitis (CM) have not been identified. In this case-control study, we characterized antibody and B profiles HIV-negative HIV-positive Vietnamese individuals Kinh ethnicity recently diagnosed with CM controls. The study included 60 no known immunocompromising condition individuals, 30 cases controls each group. Participants were matched by age, sex, HIV serostatus, CD4 count Plasma immunoglobulin (Ig) levels,...
Abstract Objectives We evaluated the efficacy and acceptability of awake-prone positioning (APP) in a randomised controlled trial, using dedicated APP implementation team wearable continuous-monitoring devices to monitor position oximetry. Methods The trial was performed at tertiary level hospital Ho Chi Minh City, Vietnam, recruiting adults (≥18 years) hospitalised with moderate or severe COVID-19 receiving supplemental oxygen therapy via nasal/facemask systems high-flow nasal canulae....
ABSTRACT In 2021, Vietnam experienced a large nationwide outbreak of COVID-19, with over 1.7 million infections and 32,000 deaths. We generated 1,303 SARS-CoV-2 whole-genome sequences, mapped out the public health measures alongside evolutionary trajectory pathogen. The Alpha variant caused sporadic outbreaks in early 2021 prior to upsurge cases associated Delta from June onward. was almost entirely confined AY.57 lineage, accounting for 99.2% 1,212 resulting single introduction. Viral...
Rising inflation rates have influenced the profitability of many ongoing projects in economies 2022.In addition, supply shortages due to Covid19 pandemic delayed projects.Accurate estimation project time and costs for a bid such uncertainties minimizes risks financial losses incurred an awarded project.Conversely, failure anticipate changes prices supplies models decreases continuance projects, leading some ripple effects society.This paper examines stochastic model include shortage...
<ns5:p>Patients with severe COVID-19 disease require monitoring pulse oximetry as a minimal requirement. In many low- and middle- income countries, this has been challenging due to lack of staff equipment. Wearable oximeters potentially offer an attractive means address need, their low cost, battery operability capacity for remote monitoring. Between July October 2021, Ho Chi Minh City experienced its first major wave SARS-CoV-2 infection, leading unprecedented demand in hospitalized...
Background Wearable devices have been used extensively both inside and outside of the hospital setting. During COVID-19 pandemic, in some contexts, there was an increased need to remotely monitor pulse saturated oxygen for patients due lack staff bedside monitors. Objective A prototype a remote monitoring system using wearable oximeter implemented at Hospital Tropical Diseases Ho Chi Minh City, Vietnam, from August December 2021. The aim this work support ongoing implementation system....
<sec> <title>BACKGROUND</title> Wearable devices have been used extensively both inside and outside of the hospital setting. During COVID-19 pandemic, in some contexts, there was an increased need to remotely monitor pulse saturated oxygen for patients due lack staff bedside monitors. </sec> <title>OBJECTIVE</title> A prototype a remote monitoring system using wearable oximeter implemented at Hospital Tropical Diseases Ho Chi Minh City, Vietnam, from August December 2021. The aim this work...