Image-sentence matching is a challenging task in the field of language and vision, which aims at measuring similarities between images sentence descriptions. Most existing methods independently map global features sentences into common space to calculate image-sentence similarity. However, similarity obtained by these may be coarse as (1) an intermediate introduced implicitly match heterogeneous level, (2) only inter-modality relations are captured while intra-modality ignored. To overcome...

Macrophages residing in the gut maintain homeostasis by orchestrating patho-gens and innocuous antigens. A disturbance macrophages leads to inflamma-tion, causing conditions such as inflammatory bowel disease (IBD). ex-hibit remarkable plasticity, they are sensitive various signals tissue micro-environment. During recent decades, microbiota has been highlighted refer-ring their critical roles immunity response. Microbiome-derived metabolites products can interact with participate progression...

Colorectal cancer (CRC) is one of the most common malignant tumors primarily affecting individuals over age 50 years. Recent studies have suggested that dysbiosis gut microbiota, a community microorganisms in human gut, closely associated with occurrence and development CRC. Additionally, inflammatory factors (IFs) also been reported to play significant role However, causal relationships between IFs, CRC remain unclear. In this study, we performed Mendelian randomization (MR) analysis using...

Abstract Background Gastric cancer (GC) remains a malignant tumor with high morbidity and mortality, accounting for approximately 1,080,000 diagnosed cases 770,000 deaths worldwide annually. Disulfidptosis, characterized by the stress-induced abnormal accumulation of disulfide, is recently identified form programmed cell death. Substantial studies have demonstrated significant influence immune clearance on progression. Therefore, we aimed to explore intrinsic correlations between...

The modernized lifestyle has been paralleled by an epidemic of inflammatory bowel disease (IBD). Excessive consumption cold beverages is especially common among the modern humans. However, whether stress contributes directly to gut barrier and gut-brain axis not clear.We conducted a model induced water. mice were treated with 14 consecutive days intragastric or water administration. We observed changes in transit colon. also employed RNA sequencing-based transcriptomic analysis identify...

Neoadjuvant therapy targeting genotype-specific gastrointestinal stromal tumors (GISTs) may be indicated in select cases. While the majority of patients respond to Imatinib with a reduction tumor size, some exhibit either poor response or resistance, necessitating exploration alternative therapeutic strategies. This report describes high-risk patient facing potential multiorgan resections whose responded poorly after 14 months therapy. After 8 transitioning Ripretinib treatment, there was...

Background: Gastric cancer (GC) is a malignant tumor with high prevalence and fatality. Cuproptosis recently identified copper-dependent programmed cell death mechanism. Multiple studies have demonstrated the profound impact of immune microenvironment on development. Hence, we decided to excavate potential functional roles cuproptosis-related genes (CRIGs) in GC their values as biomarkers. Methods: Cuproptosis- immune-related were curated from top published cuproptosis cellular immunity....

Abstract The importance of Fbxo22 in carcinogenesis has been highly documented. Here, we discussed downstream regulatory factors TNBC. RNA-sequencing was conducted for identifying differentially expressed genes, followed by construction a network. Expression patterns Fbxo22/KDM5A TNBC were determined their correlation with the prognosis analyzed. Then, regulation mechanisms between and KDM5A as well H3K4me3 assayed. After silencing overexpression experiments, significance repressing...

Abstract Background and purpose Ferroptosis is a form of regulated cell death characterized by iron-dependent lipid peroxidation. Its role in cancer metastasis remains unclear. In this study, we aimed to investigate the potential involvement ferroptosis gastric (GC) metastasis. Methods GC cells (AGS, MKN45, HGC27) were used explore single clustered with extracellular matrix (ECM) detachment vitro. We overexpressed glutathione peroxidase 4 (GPX4) inhibit assessed changes proliferation,...

We conducted a proteomic analysis using mass spectrometry to identify and validate protein biomarkers for accurately predicting recurrence risk in gastrointestinal stromal tumors (GIST) patients, focusing on differentially expressed proteins metastatic versus primary GIST tissues. selected five biomarkers-GPX4, RBM4, TPM3, PFKFB2, PGAM5-and validated their expressions of recurrent non-recurrent patients via immunohistochemistry. Our the association between these with recurrence-free survival...

<title>Abstract</title> <bold>Background: </bold>The measurement of serum PSA concentrations has been a crucial tool for prostate cancer screening several decades. Obesity shown to affect in various ways. This study aims examine the relationship between and precise indicators obesity fat distribution, including total percent (TPF), android (APF), gynoid (GPF). <bold>Methods: </bold>This included 1870 participants with detailed adiposity data complete concentration from NHANES 2001-2010....

The deleterious impact of lead (Pb) pollution on human health is evident in both domestic and occupational settings, provoking an inflammatory response across multiple tissue, limited attention has been devoted to its adverse effects colitis the underlying mechanisms. Peiminine (PMI) recognized for anti-inflammatory properties, yet specific lead-induced models remain elusive. Through establishment vivo vitro exposure models, suggests that can induce PMI regulates exposure-induced by...

<sec> <title>BACKGROUND</title> Primary intracranial germ cell tumors(iGCTs) are highly malignant brain tumors that predominantly occur in children and adolescents, with an incidence rate ranking third among primary East Asia(8-15%). Due to their insidious onset impact on critical functional areas of the brain, these often result irreversible abnormalities growth development, as well cognitive motor impairments affected children. Therefore, early diagnosis is vital for improving patient...

Isobam is widely used for fabricating ceramics through spontaneous gelation and has attracted considerable interest. However, the disadvantage of system low strength. The effects suitable additives mechanism by which they effectively enhance green body strength rheological behavior an aluminum nitride (AlN) slurry with 50 vol% solid loading were investigated using polyethyleneimine (PEI), hydantoin epoxy resin, trimethylolpropane triglycidyl ether (TMPGE). Results showed that acted as both...

Background Primary intracranial germ cell tumors (iGCTs) are highly malignant brain that predominantly occur in children and adolescents, with an incidence rate ranking third among primary East Asia (8%-15%). Due to their insidious onset impact on critical functional areas of the brain, these often result irreversible abnormalities growth development, as well cognitive motor impairments affected children. Therefore, early diagnosis through advanced screening techniques is vital for improving...

Background Thyroid stimulating hormone (TSH) has been proven to be closely associated with metabolic abnormalities, including obesity. The objective of this investigation was scrutinize the intricate association between TSH concentration and obesity, within adult population. study focused on a comprehensive examination relationship, delving into specific adiposity parameters such as total percent fat (TPF), android (APF), gynoid (GPF). Methods This included 809 participants aged 20 above...

The development of cross-border e-commerce has become an important endogenous driving force for China's consumption-driven economic growth. Cross-border refers to international trade activity in which transaction subjects different countries electronically conclude transactions, make payment and settlement through traditional links e-business platforms means, deliver goods complete transactions logistics long-distance warehousing. Big data mining engine is also limited by its professional...