A5064706306- Acute Kidney Injury Research
- Cardiac Arrest and Resuscitation
- Electrolyte and hormonal disorders
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Emergency and Acute Care Studies
- Fibroblast Growth Factor Research
- Neuroscience of respiration and sleep
- Disaster Response and Management
- Sepsis Diagnosis and Treatment
- Cardiovascular Issues in Pregnancy
- Genetic Syndromes and Imprinting
- Organ Donation and Transplantation
- Cardiac Structural Anomalies and Repair
- Parathyroid Disorders and Treatments
- Pharmacological Effects and Toxicity Studies
- Injury Epidemiology and Prevention
- Congenital Heart Disease Studies
- Hemodynamic Monitoring and Therapy
- Trauma and Emergency Care Studies
- Traumatic Brain Injury and Neurovascular Disturbances
Unity Health Toronto
2023-2025
St. Michael's Hospital
2022-2025
University of Toronto
2024
Occupational Cancer Research Centre
2024
Objectives: Among critically ill patients with severe acute kidney injury (AKI) who lack emergent indications for renal replacement therapy (RRT), a strategy of preemptive RRT initiation does not lead to improved outcomes. However, persistent AKI and without urgent RRT, the safety prolonged delays in is unclear. We sought assess association between progressively longer clinical Design: A post hoc secondary analysis. Setting: The multinational STandard vs. Accelerated Renal Replacement...
Background: The Standard Versus Accelerated Initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) Trial showed that among critically ill patients with AKI, an accelerated kidney replacement therapy (KRT) initiation strategy resulted more KRT dependence at 90 days, as compared to a standard strategy. However, it is unclear whether this difference exists participants who likely would have been treated usual practice. Methods: Secondary analysis the STARRT-AKI randomized...
Abstract Background Among critically ill patients with acute kidney injury (AKI), earlier initiation of renal replacement therapy (RRT) may mitigate fluid accumulation and confer better outcomes among individuals greater overload at randomization. Methods We conducted a pre-planned post hoc analysis the STandard versus Accelerated Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial. evaluated effect accelerated RRT on cumulative balance over course 14 days following...
We sought to describe the impact of COVID-19 pandemic on care provided by Canadian emergency medical system (EMS) clinicians patients suffering out hospital cardiac arrest (OHCA), and whether any observed changes persisted beyond initial phase pandemic.
Background: Patient reported outcomes (PROs) are important measures in acquired heart disease but have not been well defined Adult Congenital Heart Disease (ACHD). Our aim was to explore the discriminatory capacity of PRO survey tools Fontan circulatory failure (FCF). Methods: Consecutive adults were enrolled from our ambulatory clinics. Inclusion criteria age ≥18 years, a circulation or hemodynamically insignificant shunt lesion, and sufficient cognitive/language abilities complete PROs. A...
Out-of-hospital cardiac arrest (OHCA) remains a prominent medical concern worldwide. Epidemiologic metrics and trends over time for OHCA cases in Canada are not well defined. This study evaluated geographic differences the incidence outcomes of patients admitted to hospitals across Canada, during period 2013-2017. population-based retrospective cohort included 10,492 nontraumatic aged 2-85 years (66% male) who were an acute-care hospital any Canadian province or territory (excluding Quebec)...
Background: The incremental prognostic value of FGF-23 with cardiovascular (CV) risk, composite kidney outcomes (KO) and treatment response was assessed in the CANVAS trial, which studied efficacy sodium glucose co-transporter 2 inhibitor canagliflozin (cana) versus placebo patients type diabetes (T2D) high CV risk. Methods: 3188 available baseline samples were studied. association between time to death or hospitalization for heart failure (HHF) (primary endpoint), HHF, death, major adverse...