A5058576694- Mitochondrial Function and Pathology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Plasma Applications and Diagnostics
- Autophagy in Disease and Therapy
- Plasma Diagnostics and Applications
- Periodontal Regeneration and Treatments
- Inflammasome and immune disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Immune cells in cancer
- Climate Change and Health Impacts
- Single-cell and spatial transcriptomics
- Enzyme Production and Characterization
- Diet, Metabolism, and Disease
- Pregnancy-related medical research
- Epigenetics and DNA Methylation
- International Maritime Law Issues
- Inflammatory Biomarkers in Disease Prognosis
- Plasma and Flow Control in Aerodynamics
- Microbial Natural Products and Biosynthesis
- Laser Applications in Dentistry and Medicine
- Nanoplatforms for cancer theranostics
- Metabolomics and Mass Spectrometry Studies
- Aerosol Filtration and Electrostatic Precipitation
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
Shanghai Sixth People's Hospital
2018-2025
Shanghai Jiao Tong University
2020-2025
Tsinghua University
2024
Minzu University of China
2022
Shanghai Ocean University
2020-2021
Shanghai University
2020
Shanghai University of Medicine and Health Sciences
2018-2020
Ruijin Hospital
2020
Peking University
2018
Xiangya Hospital Central South University
2015-2017
Mitochondria are crucial to the function of renal tubular cells, and their dynamic perturbation in many aspects is an important mechanism diabetic kidney disease (DKD). Single-nucleus RNA sequencing (snRNA-seq) technology a high-throughput analysis technique for at level single cell nucleus. Here, our DKD mouse single-cell conveys more comprehensive mitochondrial profile, which helps us further understand therapeutic response this unique organelle family drugs. After high fat diet (HFD),...
Pulmonary emphysema is one of the most important pathological manifestations chronic obstructive pulmonary disease and commonly associated with cigarette smoking. Previous studies have indicated that necroptosis, a novel non-apoptotic cell death mechanism inflammation oxidative stress, may contribute to development emphysema. Theaflavin-3,3'-digallate (TF-3), theaflavins present in black tea, known possess several bioactive properties. In study, it was demonstrated TF-3 significantly reduced...
北京大学海洋研究院, 北京 100871) 3 (北京大学自然保护与社会发展研究中心, 4 (国家海洋环境监测中心, 辽宁大连 116023
Abstract Mitochondrial 2-enoyl-acyl-carrier protein reductase (MECR) is an enzyme in the mitochondrial fatty acid synthase (mtFAS) pathway. MECR activity remains unknown mechanism of insulin resistance pathogenesis type 2 diabetes. In present study, was investigated diet-induced obese (DIO) mice. Mecr mRNA induced by cell culture, and elevated liver DIO mice presence hyperinsulinemia. However, decreased mice, reduction blocked treatment with berberine (BBR). The regulation a focus on ATP....
One new prenylated benzenoid, (±)-chevalieric acid ( 1 ), and four anthraquinone derivatives, (10 S ,12 )-, R )-chevalierone 2 – 5 together with ten previously described compounds 6 15 were isolated from the fungus Aspergillus chevalieri (L. Mangin) Thom Church. The structures of elucidated by extensive 1D 2D nuclear magnetic resonance (NMR), HRESIMS spectroscopic analysis. absolute configurations determined experimental calculated electronic circular dichroism (ECD) DP4+ Compound 10 showed...
Abstract Diffuse plasma plumes are desirable in practical applications contrast to filamentary ones, which normally formed downstream of atmospheric pressure jets. In this paper, a diffuse plume is through increasing bias voltage ( U b ) applied the electrode an argon jet excited by negatively pulsed voltage. Results indicate that when low, transits with . The discharge initiating at rising edge attributes plume, while falling contributes filament plume. For intensity decreases oxygen...
Objective: To explore the value of cathepsin S in bronchoalveolar lavage fluid (BALF) patients with chronic obstructive pulmonary disease (COPD) evaluation function and CT phenotypes. Method: From April 2014 to 2017, 46 stable COPD were enrolled, 29 healthy volunteers served as control group. The divided into 4 subgroups: GOLD Ⅰ(n=12), Ⅱ(n=6), Ⅲ(n=14), Ⅳ(n=14). levels IFN-γ BALF determined by enzyme-linked immunosorbent assay (ELISA). percentage ratio low attenuation area total lung (LAA%),...
To evaluate the role of membrane sialyltransferase in initiation platelet aggregation, we studied stimulatory effect epinephrine and adenosine diphosphate inhibitory aspirin on surface sialyl transferase activity. The enzyme activity was assayed under optimal conditions as determined previously. assay mixture consisted intact washed human platelets, CMP-14C-sialic acid, desialated fetuin, Mn2+ buffer to a final volume 1 ml. enhanced 172% control by 1μH, 152% 5μM 146% 10μM epinephrine....