A5101473205- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Chronic Lymphocytic Leukemia Research
- Statistical Methods in Clinical Trials
- Genetic factors in colorectal cancer
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Lymphoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Childhood Cancer Survivors' Quality of Life
- Optimal Experimental Design Methods
- Chronic Myeloid Leukemia Treatments
- Neuroblastoma Research and Treatments
- Sarcoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Occupational and environmental lung diseases
- Infection Control in Healthcare
- Computational Drug Discovery Methods
Shanghai Jiao Tong University
2025
Shanghai Sixth People's Hospital
2025
Moffitt Cancer Center
2024-2025
Mayo Clinic
2015-2024
Mayo Clinic in Florida
2016-2024
Mayo Clinic in Arizona
2015-2023
Alliance Data (United States)
2019-2023
Anhui Medical University
2022
First Affiliated Hospital of Anhui Medical University
2022
WinnMed
2018-2022
Purpose This multinational study evaluated the antitumor activity of nivolumab in nasopharyngeal carcinoma (NPC). Tumor and plasma-based biomarkers were investigated an exploratory analysis. Patients Methods with multiply pretreated recurrent or metastatic NPC treated until disease progression. The primary end point was objective response rate (ORR) secondary points included survival toxicity. expression programmed death-ligand 1 (PD-L1) human leukocyte antigens A B archived tumors plasma...
Lineage-ambiguous leukemias are high-risk malignancies of poorly understood genetic basis. Here, we describe a distinct subgroup acute leukemia with expression myeloid, T lymphoid, and stem cell markers driven by aberrant allele-specific deregulation BCL11B, master transcription factor responsible for thymic T-lineage commitment specification. Mechanistically, this was chromosomal rearrangements that juxtapose BCL11B to superenhancers active in hematopoietic progenitors, or focal...
7006 Background: Older adult patients (pts) with Philadelphia-chromosome-negative (Ph-) acute lymphoblastic leukemia (ALL) have poor survival chemotherapy. The α-CD22 Ab-drug conjugate inotuzumab ozogamicin (InO) and α-CD19/CD3 T-cell engager blinatumomab (blina) were each superior to chemotherapy in Phase III studies relapsed/refractory B-ALL. Because InO induces high CR rates blina can induce durable remissions low burden disease, we conducted a II trial of induction then for older adults...
Mitochondria are crucial to the function of renal tubular cells, and their dynamic perturbation in many aspects is an important mechanism diabetic kidney disease (DKD). Single-nucleus RNA sequencing (snRNA-seq) technology a high-throughput analysis technique for at level single cell nucleus. Here, our DKD mouse single-cell conveys more comprehensive mitochondrial profile, which helps us further understand therapeutic response this unique organelle family drugs. After high fat diet (HFD),...
Abstract Background Acute lymphoblastic leukemia (ALL) in adults is aggressive, with long‐term outcomes impacted by treatment resistance and toxicity. CD52 expressed most cases of B‐ T‐lineage ALL. Alemtuzumab, a humanized immunoglobulin G1 monoclonal antibody that targets CD52, was identified as potential agent to improve efficacy without increasing Methods In this phase 1/2 study (Cancer Leukemia Group B [CALGB] 10102, NCT00061945), course single‐agent alemtuzumab intercalated into CALGB...
A variety of nursing home quality improvement programs have been implemented during the last decade but their implications for racial disparities on are unknown.
// Nilofer S. Azad 1 , Anthony el-Khoueiry 2 Jun Yin 3 Ann L. Oberg Patrick Flynn 4 Douglas Adkins 5 Anup Sharma Daniel J. Weisenberger Thomas Brown Prakriti Medvari Peter A. Jones 6 Hariharan Easwaran Ihab Kamel Nathan Bahary 7 George Kim 8 Joel Picus 9 Henry C. Pitot Charles Erlichman Ross Donehower Hui Shen W. Laird Richard Piekarz Stephen Baylin and Nita Ahuja Johns Hopkins University, Baltimore, MD, USA University of Southern California, Los Angeles, CA, Mayo Clinic, Rochestor, MN,...
Background: Anaplastic thyroid cancer (ATC) has poor prognosis with median overall survival (OS) of ∼6 months. We previously reported high PD-1/PDL-1 staining in ATC, raising the possibility productive application immunotherapeutic pembrolizumab. However, having found pembrolizumab to anecdotally have limited single-agent activity we sought alternatively define whether might synergistically combine chemoradiotherapy as initial ATC therapy. Methods: An investigator-initiated therapeutic phase...
Adolescents and young adults (AYAs) with acute lymphoblastic leukemia have improved outcomes when treated pediatric-inspired regimens. CALGB 10403 was the largest prospective study to evaluate feasibility of using a pediatric regimen in AYAs up 40 years age. This article presents toxicity events observed compares these toxicities vs those among on same arm companion Children's Oncology Group (COG) AALL0232 study. Toxicities were similar COG AALL0232. Some grade 3 4 adverse more often...
Hepatocellular carcinoma (HCC) remains one of the deadliest malignancies worldwide. One major obstacle to treatment is a lack effective molecular-targeted therapies. In this study, we find that EphA2 expression and signaling are enriched in human HCC associated with poor prognosis. Loss suppresses initiation growth both vitro vivo. Furthermore, CRISPR/CAS9-mediated inhibition significantly delays tumor development genetically engineered murine model HCC. Mechanistically, discover targeting...
Summary The landscape of oncology drug development has recently changed with the emergence molecularly targeted agents and immunotherapies. These new therapeutic appear more likely to induce multiple low or moderate grade toxicities rather than dose limiting toxicities. Various model-based finding designs toxicity severity scoring systems have been proposed account for grades, but they are difficult implement because use complicated dose–toxicity models requirement refit model at each...
Prostate-specific membrane antigen (PSMA) is a validated target for molecular diagnostics and targeted radionuclide therapy. Our purpose was to evaluate PSMA expression in hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA), hepatic adenoma (HCA); investigate the genetic pathways HCC associated with expression; detection rate
Background: Bimiralisib is a pan-PI3K/mTOR inhibitor demonstrating antitumor efficacy in preclinical models. The objectives of this study were to identify maximum tolerated dose (MTD), pharmacokinetics (PK), dosing schedule, and adverse events (AEs) patients with advanced solid tumors. Patients Methods: received oral bimiralisib determine the MTD one continuous (once daily) two intermittent schedules (A: Days 1, 2 weekly; B: 4 weekly) until progression or unacceptable AEs occurred. Results:...
BACKGROUND: To prevent transmission, some pediatric units require clinicians to wear gloves for all patient contacts during RSV season. We sought assess whether a mandatory gloving policy reduced the risk of other health care–acquired infections (HAIs). METHODS: This retrospective cohort study included patients admitted tertiary care center between 2002 and 2010. Poisson regression models were used measure association HAI incidence. Autoregressive adjust time correlation. RESULTS: During...
Hand hygiene surveillance programs that rely on direct observations of healthcare worker activity may be limited by the Hawthorne effect. In addition, comparing compliance rates from period to requires adequately sized samples observations. We aimed statistically determine whether effect is stable over an observation and derive sample sizes necessary compare rates.Prospective multicenter cohort study.Five intensive care units 6 medical/surgical wards in 3 geographically distinct acute...
Abstract Background Carcinoembryonic antigen (CEA) levels are used in conjunction with imaging to monitor response systemic therapy metastatic colorectal cancer (mCRC). We sought identify a threshold for CEA change from baseline predict progressive disease (PD) mCRC patients receiving first-line therapy. Methods Patients trials collected the ARCAD database were included if was at least 10 ng/mL and repeat available within 14 days of first restaging scan. Optimal cutoffs identified by...
Abstract Background Unplanned subgroup analyses from several studies have suggested primary tumor sidedness (PTS) as a potential prognostic and predictive parameter in metastatic colorectal cancer (mCRC). We aimed to investigate the impact of PTS on outcomes mCRC patients. Methods data 9277 patients 12 first-line randomized trials ARCAD database were pooled. Overall survival (OS) progression-free (PFS) assessed using Kaplan-Meier Cox models adjusting for age, sex, performance status, prior...
Abstract Overexpression of B-cell leukemia/lymphoma 2 (BCL2) renders acute myeloid leukemia (AML) cells resistant to chemotherapy and has been associated with unfavorable outcomes. Oblimersen (G3139) is a phosphorothioate 18-mer antisense oligonucleotide directed against the first 6 BCL2 codons. In phase 1 study AML patients treated G3139, cytarabine, daunorubicin induction cytarabine consolidation, no antisense-related toxicity was reported, downregulation occurred in achieving complete...