A5112387629- Vibrio bacteria research studies
- DNA Repair Mechanisms
- Cancer therapeutics and mechanisms
- Antibiotic Resistance in Bacteria
- Escherichia coli research studies
- Colorectal Cancer Treatments and Studies
- Cancer-related molecular mechanisms research
- Heat shock proteins research
- Urinary Tract Infections Management
- Cancer-related Molecular Pathways
- Power Systems and Renewable Energy
- Yersinia bacterium, plague, ectoparasites research
- Pregnancy and preeclampsia studies
- Lung Cancer Treatments and Mutations
- MicroRNA in disease regulation
- Ubiquitin and proteasome pathways
- Advanced Battery Technologies Research
- Antioxidant Activity and Oxidative Stress
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Plant Pathogenic Bacteria Studies
- Electric and Hybrid Vehicle Technologies
- Tannin, Tannase and Anticancer Activities
- Metal complexes synthesis and properties
- Cancer-related gene regulation
- Effects of Radiation Exposure
Jilin University
2024
Tsinghua University
2023-2024
Shanghai Jiao Tong University
2021-2023
Southern University of Science and Technology
2023
Nanjing Medical University
2015-2022
Xuzhou Medical College
2022
Huaian First People’s Hospital
2021-2022
Second People’s Hospital of Huai’an
2022
National Chiayi University
2015-2019
In-Q-Tel
2018
Abstract The type VI secretion system (T6SS) is a double‐tubular nanomachine widely found in gram‐negative bacteria. Its spear‐like Hcp tube capable of penetrating neighboring cell for cytosol‐to‐cytosol protein delivery. However, gram‐positive bacteria have been considered impenetrable to such T6SS action. Here we report that the plant pathogen, Acidovorax citrulli (AC), could deliver an Rhs‐family nuclease effector RhsB kill not only but also Using bioinformatic, biochemical, and genetic...
The type VI secretion system (T6SS) is a spear-like nanomachine found in gram-negative pathogens for delivery of toxic effectors to neighboring bacterial and host cells. Its assembly requires tip spike complex consisting VgrG-trimer, PAAR protein, the interacting effectors. However, how controls T6SS remains elusive. Here we investigated role three VgrG-effector pairs Aeromonas dhakensis strain SSU, clinical isolate with constitutively active T6SS. By swapping VgrG tail sequences,...
Background Cholangiocarcinoma is a type of hepatobiliary tumor. For perihilar cholangiocarcinoma (pCCA), patients who experience early recurrence (ER) have poor prognosis. Preoperative accurate prediction postoperative ER can avoid unnecessary operation; however, challenging. Purpose To develop novel signature based on clinical and/or MRI radiomics features pCCA to preoperatively predict ER. Study Type Retrospective. Population One hundred eighty‐four (median age, 61.0 years; interquartile...
Widely employed by Gram-negative pathogens for competition and pathogenesis, the type six protein secretion system (T6SS) can inject toxic effectors into neighboring cells through penetration of a spear-like structure comprising long Hcp tube VgrG-PAAR spike complex. The cone-shaped PAAR is believed to sharpen T6SS spear but it remains unclear why required functions in some bacteria dispensable others. Here, we report conditional requirement Aeromonas dhakensis, an emerging human pathogen...
Astaxanthin has been demonstrated to exhibit a wide range of beneficial effects that include anti-cancer and anti-inflammatory properties.
The type VI secretion system (T6SS) belongs to the evolutionarily related group of contractile injection systems that employ a outer sheath inject rigid spear-like inner tube into target bacterial and eukaryotic cells. tip is often decorated by PAAR-repeat protein as key structural component. Many members PAAR family can also have additional diverse functions serving toxins for those with extended domains or carriers interacting toxins. A plethora toxin modules unknown been bioinformatically...
MicroRNAs (miRNAs) are a class of short non-coding RNA molecules, which diversely regulate gene expression in organisms. Although the regulatory role these small molecules has been recently explored animal spermatogenesis, miR-124 male germ cells is poorly defined. In our previous study, flotillin-2 was investigated as novel Golgi-related protein involved sperm acrosome biogenesis. The current study designed to analyze contribution regulation during mouse Luciferase assays revealed target...
Ovarian cancer (OC) is known to be the most malignant gynecologic cancers. Wnt2B, a member of Wnt family, plays critical role in tumor development. However, effect Wnt2B on occurrence and development OC remains largely uncharacterized. In this study, immunohistochemistry assay indicated that was increased our study cohort (OC). addition, expression positively correlated with TNM stages metastasis patients. markedly mediated regulation proliferation, invasion, angiogenesis. Moreover,...
Lithium-ion batteries (LIBs) are widely used in electric vehicles (EVs) and energy storage systems (ESSs) because of their high density, low self-discharge rate, good cycling performance, environmental friendliness. Nevertheless, with the extensive utilization LIBs, incidents fires explosions resulting from thermal runaway (TR) have become increasingly prevalent. The resolution safety concerns associated LIBs reduction operational risks pivotal to operation control ESSs. This paper proposes...
The widespread implementation of energy storage systems in the sector has brought their thermal safety concerns into forefront. To enhance reliability and safety, this study analyses evaluates detail based on electro-thermal coupling simulation method. Initially, we created an electrochemical-thermal evaluation model, which takes account chemical reaction heat process that place within battery. Using it is possible to simulate features system. This includes analyzing temperature distribution...
Abstract The type VI secretion system (T6SS) is one of the most powerful nanomachines employed by Gram-negative pathogens for penetrating diverse cell envelopes, including bacteria and fungi, to deliver potent effectors into target cells. While membrane-anchored contractile tubular structure T6SS well characterized, assembly process remains poorly understood. prevailing model suggests that initiates from its outer-membrane component. Here, we report a distinct cytoplasmic protein Fha in...
Etoposide (VP16) is a topoisomerase II inhibitor and has been used for the treatment of non-small cell lung cancer (NSCLC). Xeroderma pigmentosum complementation group C (XPC) protein DNA damage recognition factor in nucleotide excision repair involved regulating NSCLC proliferation viability. Heat shock 90 (Hsp90) ubiquitous molecular chaperone that responsible stabilization maturation many oncogenic proteins. In this study, we report whether Hsp90 17-allylamino-17-demethoxygeldanamycin...
Abstract The type VI secretion system (T6SS) is a double-tubular toxin-injection nanomachine widely found in gram-negative human and plant pathogens. current model depicts that the T6SS spear-like Hcp tube powered by contraction of an outer sheath to drill through envelope neighboring cell, achieving cytosol delivery. However, gram-positive bacteria seem be impenetrable such action. Here we report pathogen Acidovorax citrulli (AC) deploys highly potent kill range including Escherichia coli,...
The synthetic biology toolbox has amassed a vast number of diverse functional modules, but protein translocation modules for cell penetration and cytosol-to-cytosol delivery remain relatively scarce. type VI secretion system (T6SS), commonly found in many Gram-negative pathogens, functions as contractile device to translocate toxins prokaryotic eukaryotic cells. Here, we have assembled the T6SS Aeromonas dhakensis, an opportunistic waterborne pathogen, common laboratory strain Escherichia...