A5005527309- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Bioinformatics and Genomic Networks
- Genomics and Phylogenetic Studies
- Biofuel production and bioconversion
- Acute Ischemic Stroke Management
- Bacterial biofilms and quorum sensing
- Genetic Syndromes and Imprinting
- Microbial Metabolic Engineering and Bioproduction
- Cerebral Venous Sinus Thrombosis
- Gut microbiota and health
- Autism Spectrum Disorder Research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Antimicrobial Resistance in Staphylococcus
- Metabolomics and Mass Spectrometry Studies
- Plant Gene Expression Analysis
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Intracerebral and Subarachnoid Hemorrhage Research
- Antimicrobial Peptides and Activities
- Clostridium difficile and Clostridium perfringens research
- Sugarcane Cultivation and Processing
- Plant biochemistry and biosynthesis
Guangzhou Development Zone Hospital
2023-2024
Yunnan Agricultural University
2023
Chinese Academy of Sciences
2015
Zhejiang University
2011-2014
State Key Laboratory of Plant Physiology and Biochemistry
2011-2014
University College London
2014
The utility of buccal cells as an epithelial source tissue for epigenome-wide association studies (EWASs) remains to be demonstrated. Given the direct exposure potent carcinogens such smoke, epigenetic changes in these may provide insights into development smoke-related cancers.To perform EWAS and blood assess relative effect smoking on DNA methylation (DNAme) patterns cell types test whether DNAme are also seen cancer.In 2013, we measured at more than 480,000 CpG sites samples provided 1999...
Abstract Background Protein-protein interactions play a fundamental role in elucidating the molecular mechanisms of biomolecular function, signal transductions and metabolic pathways living organisms. Although high-throughput technologies such as yeast two-hybrid system affinity purification followed by mass spectrometry are widely used model organisms, progress protein-protein detection plants is rather slow. With this motivation, our work presents computational approach to predict Oryza...
Bacterial biofilms are particularly problematic since they become resistant to most available antibiotics. Hence, novel potential antagonists inhibit biofilm formation urgent. Here the influences of two natural products, ursolic acid and resveratrol, on clinical methicillin-resistant Staphylococcus aureus (MRSA) isolate were investigated using RNA-seq differentially expressed genes analyzed Cuffdiff. The results showed that inhibition may reduce amino acids metabolism adhesins expression...
Recent studies have demonstrated that the DNA methylome changes with age. This epigenetic drift may deep implications for cellular differentiation and disease development. However, it remains unclear how much of this is functional or caused by underlying in cell subtype composition. Moreover, no study has yet comprehensively explored at different genomic length scales relation to regulatory elements. Here we conduct an in-depth analysis blood tissue. We demonstrate most age-associated...
There is a growing number of studies generating matched Illumina Infinium HumanMethylation450 and gene expression data, yet there corresponding shortage statistical tools aimed at their integrative analysis. Such are important for the discovery epigenetically regulated modules or molecular pathways, which play key roles in cellular differentiation disease.Here, we present novel functional supervised algorithm, called Functional Epigenetic Modules (FEM), analysis 450k DNA methylation...
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition characterized by social communication deficiencies and stereotypic behaviors influenced hereditary and/or environmental risk factors. There are currently no approved medications for treating the core symptoms of ASD. Human fecal microbiota transplantation (FMT) has emerged as potential intervention to improve autistic symptoms, but underlying mechanisms not fully understood. In this study, we evaluated effects...
Erianthus produces substantial biomass, exhibits a good Brix value, and shows wide environmental adaptability, making it potential biofuel plant. In contrast to closely related sorghum sugarcane, can grow in degraded soils, thus releasing pressure on agricultural lands used for production. However, the lack of genomic resources hinders its genetic improvement, limiting present study, we generated chromosome-scale reference genome fulvus Nees. The size estimated by flow cytometry was 937 Mb,...
Abstract Plant protein-protein interaction networks have not been identified by large-scale experiments. In order to better understand the protein interactions in rice, Predicted Rice Interactome Network (PRIN; http://bis.zju.edu.cn/prin/) presented 76,585 predicted involving 5,049 rice proteins. After mapping genomic features of (GO annotation, subcellular localization prediction, and gene expression), we found that a well-annotated biologically significant network is rich enough capture...
Abstract Aim As the main type of stroke, incidence cerebral venous thrombosis (CVT) has been rising. However, comprehensive mechanisms behind it remain unclear. Thus, multi‐omics study is required to investigate mechanism after CVT and elucidate characteristic pathology stroke arterial stroke. Methods Adult rats were subjected MCAO models. Whole‐transcriptome sequencing (RNA‐seq) untargeted metabolomics analysis performed construct transcriptome metabolism profiles rat brains also MCAO. The...
Ischemic stroke (IS) is responsible for major causes of global death and disability, which promoting angiogenesis a promising therapeutic strategy. This study analyzed circular RNA PDS5B (circPDS5B) its related mechanisms in IS.In the permanent middle cerebral artery occlusion (pMCAO) mouse model, circPDS5B, microRNA (miR)-223-3p, NOTCH2 levels were checked. By testing neurologic function, neuronal apoptosis, expression angiogenesis-related proteins pMCAO mice, protective effects circPDS5B...