A5081406120- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Immune cells in cancer
- MicroRNA in disease regulation
- Renal cell carcinoma treatment
- Lipid metabolism and disorders
- Circular RNAs in diseases
- Autophagy in Disease and Therapy
- Urological Disorders and Treatments
- RNA Interference and Gene Delivery
- Sepsis Diagnosis and Treatment
- Cancer Cells and Metastasis
- Microtubule and mitosis dynamics
- Immune Response and Inflammation
- Cancer-related gene regulation
- Nanoparticle-Based Drug Delivery
- Pediatric health and respiratory diseases
- Kruppel-like factors research
- Fibroblast Growth Factor Research
- Artificial Intelligence in Healthcare
- Enhanced Recovery After Surgery
- Traditional Chinese Medicine Studies
- Fatty Acid Research and Health
- Image Processing Techniques and Applications
Third Xiangya Hospital
2015-2025
Central South University
2009-2025
Institute of Software
2023
Huazhong University of Science and Technology
2023
Changchun Obstetrics and Gynecology Hospital
2011
Xi'an Jiaotong University
2008
Non-alcoholic fatty liver disease (NAFLD) has emerged as a public health issue with prevalence of 15-30% in Western populations and 6-25% Asian populations. Certain studies have revealed the alteration microRNA (miRNA or miR) profiles NAFLD it been suggested that miR-21 is associated NAFLD. In present study, we measured serum levels patients also performed vitro experiments using cellular model to further investigate effects on triglyceride cholesterol metabolism. Furthermore, novel target...
Nonalcoholic fatty liver disease (NAFLD) has become a common health care burden worldwide. The high heterogeneity of NAFLD remains elusive and impairs outcomes clinical diagnosis pharmacotherapy. Several classifications have been proposed on the basis clinical, genetic, alcoholic, or serum metabolic analyses. Yet, accurately predicting progression to cirrhosis hepatocellular carcinoma (HCC) in patients challenge. Here, Chinese cohort patients, we classified into three distinct molecular...
Non-alcoholic fatty liver disease (NAFLD) is a common disorder poising burgeoning health problem to humans. Recent studies have shown that long non-coding RNA (lncRNA) plays critical roles in myriad of biological processes and human diseases. Since the lncRNA NAFLD remain unknown, they were investigated study. Microarray expression profiling mRNAs lncRNAs was conducted using extracted from patients with without NAFLD. One thousand seven hundred thirty-five 1485 mRNA found differentially...
Abstract Our study aimed to explore the function of circRNA_0001805 in pathogenesis NAFLD and underlying mechanism. A nanodrug system (GA-RM/GZ/PL) was constructed overexpress specifically hepatocytes for treatment NAFLD. Fat droplet accumulation cultured cells mouse hepatic tissues detected using Oil Red O or H&E staining. The relative expression circRNAs, genes associated with lipogenesis quantified by qRT-PCR. Interactions between miR-106a-5p/miR-320a, miR-106a-5p/miR-320a ABCA1/CPT1...
Acute lung injury (ALI) is a life-threatening disease where alveolar macrophages (AMs) play central role both in the early phase to initiate inflammatory responses and late promote tissue repair. In this study, we examined whether BML-111, lipoxin A4 receptor agonist, could alter phenotypes of AM thus present prophylactic benefits for ALI.In vitro, isolated AMs were treated with lipopolysaccharide (LPS) induce ALI. response BML-111 pre-treatment, apoptosis autophagy by flow cytometry,...
Gliomas advance rapidly and are associated with a poor prognosis. Epithelial-mesenchymal transition (EMT) accelerates the progression of gliomas, exerting pivotal role in glioma development. Proteasome subunit alpha type-2 (PSMA2) exhibits high expression levels gliomas. however, its specific involvement correlation EMT remain elusive. This study aims to elucidate PSMA2 potential association EMT. Online tools were employed analyze patterns survival curves The relationship between various...
Autophagy enhancement in septic liver injury can play a protective role. Nerveless, the mechanism of autophagy-mediated needs further investigation. Our study demonstrated that condition, GLI Family Zinc Finger 2 (GLI2) was elevated, whereas peroxisome-proliferator-activated receptor α (PPARα) downregulated. Suppressing GLI2 or synovialapoptosis inhibitor 1 (SYVN1) LPS-exposed cells increased PPARα levels, enhanced cell viability and autophagy, while inhibiting apoptosis. LPS GLI2-SYVN1...
5(S),6(R)-7-trihydroxymethyl heptanoate (BML-111) is an lipoxin A4 receptor agonist, which modulates the immune response and attenuates hemorrhagic shock-induced acute lung injury. However, role of BML-111 in sepsis intestinal mucosal barrier are not well understood. Therefore, present study was designed to investigate effect on a rat model sepsis. Furthermore, molecular mechanism action evaluated. The cecal ligation puncture-induced constructed, administered at three different doses....
Abstract Nonalcoholic fatty liver disease (NAFLD) is regarded as a threat to public health; however, the pathologic mechanism of NAFLD not fully understood. We attempted identify abnormally expressed long noncoding RNA (lncRNAs) and messenger that may affect occurrence development in this study. The expression differentially lncRNAs was determined oleic acid (OA)‐treated L02 cells, functions CCAT1 lipid droplet formation were evaluated vitro. Differentially genes (DEGs) analyzed by...
Objective. Overexpression of elongation factor-1α (EF-1α) has been demonstrated to be related increased cell proliferation, oncogenic transformation and delayed senescence. The purpose this study was determine whether EF-1α expression affects the progression prostate cancer (PCa), it can used as a prognostic marker for PCa. Material methods. evaluated by immunostaining in paraffin-embedded specimens prostates obtained from 80 patients with Correlations patients' ages, Gleason scores,...
Sepsis is a leading cause of morbidity and mortality in hospitalized patients. Up to now, there are no well-established longitudinal networks from molecular mechanisms clinical phenotypes sepsis. Adding the problem, about one five patients presented with diabetes. For this subgroup, management difficult, prognosis difficult evaluate. From three databases, total 7,001 were enrolled on basis sepsis-3 standard diabetes diagnosis. Input variable selection based result correlation analysis...
Non-alcoholic fatty liver disease has seriously affected people's health. Recent studies have found that N6-methyladenosine (m6A) methylation is involved in the lipid metabolism process of body, but study on level m6A modification NAFLD still not available. This aims to explore changes RNA tissues, and provide experimental theoretical basis for in-depth role occurrence development NAFLD.
Bloodstream infections in emergency patients have a high incidence, severe disease progression, and rapid deterioration. Early administration of appropriate antimicrobial agents is crucial for improving patient outcomes. This study aims to investigate the pathogen distribution, resistance patterns bloodstream patients, providing reference rational antibiotic use clinical practice. Medical records diagnosed with department hospital Hunan Province between January 2018 October 2022 were...
To analyze the characteristics of long non-coding RNA (lncRNA) expression in non-alcoholic fatty liver disease (NAFLD). Methods: lncRNA-mRNA microarray was conducted on tissue samples from 10 patients with simple gallbladder stone (5 NAFLD and 5 normal samples), differentially expressed lncRNA analyzed by bioinformatics technology. Results: Compared samples, there were abnormal 1 735 lncRNAs 485 mRNAs samples. Among them, 535 760 up-regulated, 200 725 down-regulated. Conclusion: liver,...
To explore the molecular mechanism of fibroblast growth factor 8b (FGF8b) in promoting epithelial-mesenchymal transition prostate cancer DU145 cells.Cells were selected three groups as follows: a block control group (DU145 cells), negative [DU145 cells transfected with empty plasmid (pcDNA3.1/DU145)], and an experimental FGF8b (FGF8b/DU145)]. The activity extracellular regulated protein kinases1/2( ERK1/2) pathway was detected by western-blot groups. FGF8b-DU145 cultured PD98059 (an ERK...
Among recent state-of-the-art realistic image super-resolution (SR) intelligent algorithms, generative adversarial networks (GANs) have achieved impressive visual performance. However, there has been the problem of unsatisfactory perception super-scored pictures with unpleasant artifacts. To address this issue and further improve quality, we proposed a perception-design-oriented PSRGAN double turbos for real-world SR. The first-perception turbo in generator network three-level structure...