A5002699659- Atmospheric chemistry and aerosols
- Lymphoma Diagnosis and Treatment
- Biomedical Ethics and Regulation
- Aluminum Alloys Composites Properties
- Vascular Malformations and Hemangiomas
- Advanced Chemical Physics Studies
- Molecular Biology Techniques and Applications
- Cultural Heritage Materials Analysis
- Lymphatic System and Diseases
- Advanced Combustion Engine Technologies
- Tumors and Oncological Cases
- Ubiquitin and proteasome pathways
- Synthesis and properties of polymers
- Heat shock proteins research
- Sperm and Testicular Function
- Endometriosis Research and Treatment
- Systemic Sclerosis and Related Diseases
- Cell death mechanisms and regulation
- Membrane Separation and Gas Transport
- Metallic Glasses and Amorphous Alloys
- Ovarian function and disorders
- Metallurgical Processes and Thermodynamics
- Biosimilars and Bioanalytical Methods
- Aluminum Alloy Microstructure Properties
- CAR-T cell therapy research
Shanghai Institute of Hematology
2015-2024
Shanghai Jiao Tong University
2014-2024
Ruijin Hospital
2024
Dalian Maritime University
2024
Yingkou Institute of Technology
2024
Shanghai Ninth People's Hospital
2017-2021
Shanghai Institute of Ceramics
2018
Chinese Academy of Sciences
2018
Tohoku University
1999
Objective To investigate the clinical outcome and endocrinological characteristics of progestin‐primed ovarian stimulation ( PPOS ) using 4 versus 10 mg medroxyprogesterone acetate MPA per day in infertile women with normal ovary reserve. Design A randomised parallel controlled trial. Setting Tertiary‐care academic medical centre. Participants cohort 300 undergoing vitro fertilisation IVF )/intracytoplasmic sperm injection ICSI treatment. Methods Human menopausal gonadotropin hMG ; 225 iu...
The activation of oncogenes can reprogram tumor cell metabolism. Here, in diffuse large B-cell lymphoma (DLBCL), serum metabolomic analysis revealed that oncogenic MYC could induce aberrant choline metabolism by transcriptionally activating the key enzyme phosphate cytidylyltransferase 1 choline-α (PCYT1A). In B-lymphoma cells, as a consequence PCYT1A upregulation, impeded cells undergo mitophagy-dependent necroptosis. DLBCL patients, overexpression was parallel with an increase MYC, well...
Cancer cells have distinct metabolomic profile. Metabolic enzymes regulate key oncogenic signaling pathways and an essential role on tumor progression. Here, serum analysis was performed in 45 patients with T-cell lymphoma (TCL) 50 healthy volunteers. The results showed that dysregulation of choline metabolism occurred TCL related to cell overexpression kinase-α (Chokα). In T-lymphoma cells, pharmacological molecular silencing Chokα significantly decreased Ras-GTP activity, AKT ERK...
Many studies have addressed the hazardous role of cigarette smoking on male fertility, but exact molecular mechanisms involved in impairments caused by nicotine remain unclear. To evaluate detrimental effects exposure spermatogenesis, two-dimensional gel electrophoresis and mass spectrometry analysis were performed to screen identify differentially expressed proteins from testes mice exposed daily. Data mining indicated that 15 identified mainly actin cytoskeleton regulation tricarboxylic...
Port‐wine macrocheilia (PWM) involves a congenital, progressive capillary malformation that results in soft‐tissue hypertrophy the lips. Its aetiology has not yet been fully elucidated. To investigate frequencies of GNAQ mutation different tissues from patients with PWM, including skin, mucosa, gland and muscle, using samples obtained during cheiloplasty. Targeted next‐generation sequencing was designed performed to assess DNA extracted 80 affected 20 PWM. The R183Q detected but found 90%,...
The mechanism of hydrogen abstraction in the reaction 3-methyl-1-butanol with an OH radical was investigated by quantum chemical calculations. total consists five channels (R1–R5), channel R3 having lowest energy barrier (5.4 kcal·mol−1) and R4 highest (13.2 kcal·mol−1). All are exothermic reactions lower barriers. Thermodynamic parameters, including constant pressure molar heat capacity CPo, enthalpy formation ΔfHo, entropy So, for all reactants products, were researched using CBS-QB3 level...
In this paper, the imidization mechanism of polyamic acid to prepare polyimide has been studied by density functional theory (DFT) method. Our results have shown that would proceed via two different reaction paths. The activation barrier hydrogen transfer closer carboxylate oxygen in COOH is 220.35 kJ/mol while hydroxyl 220.70 kJ/mol. Both paths run actual thermal process with high barriers. energy interpreted fact additional or catalyst usually needed during imidization. Moreover, intrinsic...