A5012128264- Chemical Reactions and Isotopes
- Fluorine in Organic Chemistry
- Medical Imaging Techniques and Applications
- Chemical Synthesis and Analysis
- Click Chemistry and Applications
- Cancer, Hypoxia, and Metabolism
- Chemical Synthesis and Characterization
- Pharmacogenetics and Drug Metabolism
- Radioactive element chemistry and processing
- CO2 Reduction Techniques and Catalysts
- Radiopharmaceutical Chemistry and Applications
CEA Paris-Saclay
2022-2023
Université Paris-Saclay
2022-2023
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2022-2023
CEA Paris-Saclay - Etablissement de Saclay
2023
The need for carbon-labeled radiotracers is increasingly higher in drug discovery and development (carbon-14, β-, t1/2 = 5730 years) as well positron emission tomography (PET) vivo molecular imaging applications (carbon-11, β+, 20.4 min). However, the structural diversity of still systematically driven by narrow available labeled sources methodologies. In this context, emergence carbon dioxide radical anion chemistry might set forth potential unexplored opportunities. Based on a dynamic...
Abstract In contrast to stable and natural abundant carbon‐12, the synthesis of organic molecules with carbon (radio)isotopes must be conceived optimized in order navigate through hurdles radiochemical requirements, such as high costs starting materials, harsh conditions radioactive waste generation. addition, it initiate from small cohort available C‐labeled building blocks. For long time, multi‐step approaches have represented sole patterns. On other side, development chemical reactions...
Abstract Carbon isotope labeling is a useful technology for tracking the fate of organic compounds in environment and living organisms. In this context, development robust general methodologies amenable to direct functionalization CO 2 remains significant task. communication, de‐risking approach was developed evaluate robustness Staudinger aza‐Wittig sequence carbon labeling. This based on [ 14 C]CO screening that allowed investigate tolerance procedure with most representative heterocycles...
The need for carbon-labeled radiotracers is increasingly higher in drug discovery and development (carbon-14, -, t1/2 = 5730 years) as well PET, vivo molecular imaging applications (carbon-11, +, 20.4 min). However, the structural diversity of still systematically driven by narrow available labeled sources methodologies. In this context, emergence carbon dioxide radical anion chemistry might set forth potential unexplored opportunities. Based on a dynamic isotopic equilibration between...