A5075879514- Medical Imaging Techniques and Applications
- Drug Transport and Resistance Mechanisms
- Radiopharmaceutical Chemistry and Applications
- Epilepsy research and treatment
- Alzheimer's disease research and treatments
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Chemical Reactions and Isotopes
- Dementia and Cognitive Impairment Research
- Fluorine in Organic Chemistry
- Lanthanide and Transition Metal Complexes
- Glioma Diagnosis and Treatment
- Carbon dioxide utilization in catalysis
- Pain Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- MRI in cancer diagnosis
- Neuropeptides and Animal Physiology
- Opioid Use Disorder Treatment
- S100 Proteins and Annexins
- Cancer, Hypoxia, and Metabolism
- Amino Acid Enzymes and Metabolism
- Parkinson's Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Cannabis and Cannabinoid Research
Laboratoire d’Imagerie Biomédicale
2020-2025
Université Paris-Saclay
2016-2025
Centre National de la Recherche Scientifique
2016-2025
CEA Paris-Saclay
2016-2025
Inserm
2016-2025
Institut d'Imagerie Biomédicale
2015-2025
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2016-2025
CEA Paris-Saclay - Etablissement de Saclay
2023
Université Paris-Sud
2015-2021
Centre Hospitalier d'Orsay
2017-2021
Although brain neuroinflammation may play an instrumental role in the pathophysiology of Alzheimer's disease, its actual impact on disease progression remains controversial, being reported as either detrimental or protective. This work aimed at investigating temporal relationship between microglial activation and clinical disease. First, a large cohort patients with we analysed predictive value assessed by 18F-DPA-714 PET imaging functional, cognitive MRI biomarkers outcomes after 2-year...
The need for carbon-labeled radiotracers is increasingly higher in drug discovery and development (carbon-14, β-, t1/2 = 5730 years) as well positron emission tomography (PET) vivo molecular imaging applications (carbon-11, β+, 20.4 min). However, the structural diversity of still systematically driven by narrow available labeled sources methodologies. In this context, emergence carbon dioxide radical anion chemistry might set forth potential unexplored opportunities. Based on a dynamic...
To evaluate whether striatal [(18)F]MNI-659 PET imaging of phosphodiesterase 10A (PDE10) serves as a sensitive and reliable biomarker neurodegeneration in longitudinal cohort participants with early Huntington disease (HD).A HD, including both premanifest or manifest motor signs, underwent clinical assessments, genetic determination, 2 sessions approximately 1 year apart. Eleven healthy control (HC) assessments once. Striatal binding potentials (BPnd) were estimated for brain regions...
Abstract Neuropathological studies showed early locus coeruleus (LC) neuronal loss associated with tauopathy in Alzheimer’s Disease (AD). We used the LC signal intensity (LC‐I) on 3T MRI to assess integrity AD ( n = 37) and controls 17). The LC‐I was decreased regardless of typical (amnesic) atypical presentation (logopenic aphasia/visuo‐spatial deficit), from prodromal stage, independently amyloid load measured by PiB‐PET. correlated memory performance AD. This supports pathophysiological...
Objectives To explore whether regional tau binding measured at baseline is associated with the rapidity of Alzheimer’s disease (AD) progression over 2 years, as assessed by decline in specified cognitive domains, and brain atrophy, comparison amyloid-positron emission tomography (PET), MRI cerebrospinal fluid (CSF) biomarkers. Methods Thirty-six patients AD (positive CSF biomarkers amyloid-PET) 15 controls underwent a complete neuropsychological assessment, 3T MRI, [ 11 C]-PiB 18...
Harvesting sunlight to drive carbon dioxide (CO2) valorisation represents an ideal concept support a sustainable and carbon-neutral economy. While the photochemical reduction of CO2 monoxide (CO) has emerged as hot research topic, full CO2-to-CO conversion remains often-overlooked criterion that prevents productive direct CO into high-value-added chemicals. Herein, we report photocatalytic process unlocks fast (<10 min) its straightforward human health related field radiochemistry with...
A robust, click-chemistry-inspired procedure for radiolabeling of cyclic ureas was developed. This protocol, suitable all carbon isotopes (11 C, 13 14 C), is based on the direct functionalization dioxide: universal building block radiolabeling. The strategy operationally simple and reproducible in different radiochemistry centers, exhibits remarkably wide substrate scope with short reaction times, demonstrates superior reactivity as compared to previously reported systems. With this...
The effects of metoclopramide on the central nervous system (CNS) in patients suggest substantial brain distribution. Previous data that kinetics may nonetheless be controlled by ATP-binding cassette (ABC) transporters expressed at blood–brain barrier. We used <sup>11</sup>C-metoclopramide PET imaging to elucidate kinetic impact transporter function exposure brain. <b>Methods:</b><sup>11</sup>C-metoclopramide transport P-glycoprotein (P-gp; ABCB1) and breast cancer resistance protein (BCRP;...
PET with avid substrates of P-glycoprotein (ABCB1) provided evidence the role this efflux transporter in effectively restricting brain penetration its across human blood–brain barrier (BBB). This may not reflect situation for weak ABCB1 including several antidepressants, antiepileptic drugs, and neuroleptics, which exert central nervous system effects despite being transported by ABCB1. We performed substrate <sup>11</sup>C-metoclopramide humans to elucidate impact function on kinetics....
In this preclinical pilot study, we used [11C]UCB-J PET imaging to monitor the synaptic modulation in depression and after fluoxetine. was performed a validated mouse model of depression/anxiety (CORT model), effect 5-week treatment with fluoxetine tested. Depression/anxiety phenotype antidepressant action were confirmed using novelty-suppressed feeding test, previously CORT model. data showed significant decreases volume distribution (VT) most brain regions mice compared controls 5 weeks...
Abstract The COVID-19 pandemic has caused at least 780 million cases globally. While available treatments and vaccines have reduced the mortality rate, spread evolution of virus are ongoing processes. Despite extensive research, long-term impact SARS-CoV-2 infection is still poorly understood requires further investigation. Routine analysis provides limited access to tissues patients, necessitating alternative approaches investigate viral dissemination in organism. We address this issue by...
The tyrosine kinase inhibitor erlotinib poorly penetrates the blood–brain barrier (BBB) because of efflux transport by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2), thereby limiting its utility in treatment non–small cell lung metastases brain. Pharmacologic strategies to inhibit ABCB1/ABCG2-mediated at BBB have been successfully developed rodents, but it remains unclear whether these can be translated humans given pronounced species differences ABCG2/ABCB1 expression...
Summary Objective Mesiotemporal lobe epilepsy is the most common type of drug‐resistant partial epilepsy, with a specific history that often begins status epilepticus due to various neurological insults followed by silent period. During this period, before first seizure occurs, lesion develops, described as unilateral hippocampal sclerosis ( HS ). It still challenging determine which drugs, administered at time point, will be effective during formation epileptic process. Neuroinflammation...
PET imaging using radiolabeled avid substrates of the ATP-binding cassette (ABC) transporter P-glycoprotein (ABCB1) has convincingly revealed role this major efflux in limiting influx its from blood into brain across blood-brain barrier (BBB). Many drugs, such as metoclopramide, are weak ABCB1 and distribute even when is fully functional. In study, we used kinetic modeling validated simplified methods to highlight quantify impact on BBB 11C-metoclopramide, a model substrate, nonhuman...
Glioblastoma (GBM) is the most devastating brain tumor. Despite use of multimodal treatments, patients relapse, often due to highly invasive nature gliomas. However, detection glioma infiltration remains challenging. The aim this study was assess advanced PET and MRI techniques for visualizing biological activity tumor.Using multimodality imaging, we investigated [18F]DPA-714, a radiotracer targeting 18 kDa translocator protein (TSPO), [18F]FET PET, non-Gaussian diffusion (apparent...
A general approach to label urea derivatives with all carbon isotopes (<sup>11</sup>C, <sup>13</sup>C and <sup>14</sup>C) is reported.
Abstract Background The locus coeruleus (LC) and the nucleus basalis of Meynert (NBM) are altered in early stages Alzheimer’s disease (AD). Little is known about LC NBM alteration limbic-predominant age-related TDP-43 encephalopathy (LATE) frontotemporal dementia (FTD). aim present study to investigate vivo integrity patients with suspected-LATE, early-amnestic AD FTD comparison controls. Methods Seventy-two participants (23 amnestic-AD patients, 17 defined by a clinical-biological diagnosis...
Abstract A series of novel pyridine‐based Gd 3+ complexes have been prepared and studied as potential MRI contrast agents for Zn 2+ detection. By independent assessment molecular parameters affecting relaxivity, we could interpret the relaxivity changes observed upon binding in terms variations rotational motion.
A general procedure for the late-stage [11C], [13C] and [14C]carbon isotope labeling of cyclic carbamates is reported. This protocol allows incorporation carbon dioxide, primary source carbon-14 carbon-11 radioisotopes, in a direct, cost-effective sustainable manner. disconnection/reconnection strategy, involving ring opening/isotopic closure, was also implemented.
Translocator protein 18 kDa (TSPO) PET imaging is used to monitor glial activation. Recent studies have proposed TSPO as a marker of the epileptogenic zone (EZ) in drug-resistant focal epilepsy (DRFE). This study aims assess contributions using [
Upregulation of the cannabinoid type 2 receptors (CB2R) unveils inflammation processes pathological disorders, such as cancer, pain, or neurodegenerative diseases. Among others, CB2R agonist A-836339 has been labeled with carbon-11 for PET imaging and displayed promising results in a mouse model Alzheimer's disease. The aim present work was to develop fluorinated analogs labeling fluorine-18 design new tracer imaging. Seven were synthesized two three steps their binding affinities...