A5102989066- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Tissue Engineering and Regenerative Medicine
- Hepatocellular Carcinoma Treatment and Prognosis
- Medical Imaging and Pathology Studies
- Cancer Genomics and Diagnostics
Karolinska Institutet
2022-2024
A perimetastatic capsule is a strong positive prognostic factor in liver metastases, but its origin remains unclear. Here, we systematically quantify the capsule's extent and cellular composition 263 patients with colorectal cancer metastases to investigate clinical significance origin. We show that survival improves proportionally increasing encapsulation decreasing tumor-hepatocyte contact. Immunostaining reveals gradual zonation of capsule, transitioning from benign-like NGFR
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive tumor type characterized by particularly extensive stroma. While different types of cancer-associated fibroblasts (CAFs) in this desmoplastic stroma have been described, areas early invasion and nascent are understudied. Here, we identify distinctive PDAC niche within the pancreatic lobules, compartment dominated exocrine cells slender Cellular interaction profiling using machine learning on whole slide images human...
Abstract Colorectal cancer liver metastases (CRLM) grow in two major patterns defined by the histomorphology of invasion front, replacement or desmoplastic . The pattern, which a stromal rim separates tumor cells and parenchyma is strong positive prognostic factor, implying favorable biological features. However, origin perimetastatic stroma unknown underlying mechanisms are unclear. Here, we created spatial growth pattern maps resected CRLM at cell-level resolution using digital pathology...