A5103066803- Genetic Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- Mitochondrial Function and Pathology
- Myasthenia Gravis and Thymoma
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Health disparities and outcomes
- High Altitude and Hypoxia
- Neurological disorders and treatments
- Nerve injury and regeneration
- Microtubule and mitosis dynamics
- Muscle Physiology and Disorders
- Silk-based biomaterials and applications
- Nuclear Receptors and Signaling
- Neurological diseases and metabolism
- Frailty in Older Adults
- Botulinum Toxin and Related Neurological Disorders
- Dementia and Cognitive Impairment Research
- Healthcare Regulation
- Climate Change and Health Impacts
- Developmental Biology and Gene Regulation
- Parkinson's Disease and Spinal Disorders
- Pituitary Gland Disorders and Treatments
- Genetics and Neurodevelopmental Disorders
- Inhalation and Respiratory Drug Delivery
- Skin and Cellular Biology Research
National Hospital Organization
2015-2024
National Hospital for Neurology and Neurosurgery
2016
University College London
2016
Akita University
1998-2010
Research Institute for Humanity and Nature
2009
Kyoto Medical Center
2005
Kyoto University
2005
ABSTRACT Introduction This study sought to clarify whether specific cognitive abilities are impaired in patients with myotonic dystrophy type 1 (DM1) as well investigate the relationships among quality of life (QoL), function, and psychological factors. Methods Sixty DM1 were evaluated on functioning (abstract reasoning, attention/working memory, executive processing speed, visuoconstructive ability), apathy, depression, excessive daytime sleepiness, fatigue, QoL. QoL was assessed by 2...
To examine the association between food diversity and health status of Han Tibetan elderly highlanders in Qinghai Plateau, China.The study population consisted 240 community-dwelling subjects aged 60 years or more (176 subjects, 64 ones). Food was determined using an 11-item Diversity Score Kyoto (FDSK-11). Subjects were interviewed on including activities daily living (ADL), screening-based depression quality life (QOL). Blood chemical investigation carried out with diversity.ADL...
Aim: To reveal the comparison of comprehensive geriatric functions elderly highlanders in Qinghai Plateau China among three different ethnic groups. Methods: Activities daily living (ADL), screening‐based depression, quality life (QOL) and checking‐up metabolic syndrome including community‐based oral glucose tolerance test were assessed 393 community‐dwelling subjects aged 60 years or more (247 Han subjects, 49 Mongolian ones 97 Tibetan ones). Results: disabled ADL, but had higher QOL than...
Background Myotonic dystrophy type 1 involves cardiac conduction disorders. Cardiac disease can cause fatal arrhythmias or sudden death in patients with myotonic 1. Methods and Results This study enrolled 506 (aged ≥15 years; >50 cytosine-thymine-guanine repeats) was treated 9 Japanese hospitals for neuromuscular diseases from January 2006 to August 2016. We investigated genetic clinical backgrounds including health care, activities of daily living, dietary intake, involvement, respiratory...
Background: The objective of the present study is to compare findings comprehensive geriatric assessments between community‐dwelling elderly in Indonesia and those Japan. Methods: A cross‐sectional, interview‐ examination‐based was undertaken. Subjects consisted living two rural towns a town Japan: 436 people aged 62 years over who were west Java Indonesia, 411 65 Kyoto, They examined using common assessment tool. Interviews, or mail surveys conducted pertaining activities daily (ADL),...
The objective of this study is to disclose the association polycythemia with lifestyle-related diseases (hypertension, obesity and glucose intolerance) among three ethnicities in Qinghai, China.The subjects were 393 elderly people (247 Han, 97 Tibetan 49 Mongolian) aged 60 years more living Qinghai (3000 m a.s.l.) China. associated factors analyzed subjects. Excessive was defined as hemoglobin concentration over 20 mg/dL.Polycythemia men, hypoxemia, high diastolic blood pressure (DBP)...
Background: The objective of the present study is to compare findings comprehensive geriatric assessments community‐dwelling elderly people in Singapore with those Japan.. Methods: A cross‐sectional, interview‐ and examination‐based was conducted living an urban district, Choa Chu Kang, a rural town, Urausu, Hokkaido Japan. Volunteers were recruited by advertising. One hundred seventeen 163 aged 70 years over Japan, respectively, examined using common assessment tool. Interviews pertaining...
We genetically screened patients with ataxia ocular motor apraxia type 1 (AOA1)/early-onset and hypoalbuminemia (EAOH), a Japanese variant form of Friedreich’s ataxia. Three were found to have homozygous insertion mutation the aprataxin gene (689insT). An elder sister patient in this series died cerebral hemorrhage at age 45, underwent autopsy. In her cerebellar cortex, mean density Purkinje cells flocculus had predominantly decreased 6.7% normal controls, whereas other areas hemisphere...
The authors report an autopsy case of acute encephalopathy in which generalized convulsion and coma occurred after ingestion Pleurocybella porrigens (angel's wing mushroom). patient was a 65‐year‐old man who had undergone hemodialysis for 3 months due to chronic renal failure. Pathologic examination the brain revealed extensive postinfarction‐like cystic necrosis bilateral putamens multiple spotty necroses deep cerebral cerebellar cortices. In 2004, similar related mushroom endemic Japan,...
Background: Although there are several factors which may contribute to oxidative stress at high altitude, little is known about the association between and aging in community‐dwelling elderly Tibetan Plateau. Methods: Reactive oxygen species (ROS) comprehensive geriatric functions were examined among 235 subjects aged 60 years or more (146 Hans 89 Tibetans). As a marker of ROS, levels reactive metabolites (ROM) measured using d‐ROM test. Results: The rate dependence basic activities daily...
Abstract Background Several types of visual illusions can occur in Parkinson's disease (PD). However, the prevalence and specific experienced by patients with PD remain unclear. This study aimed to investigate illusions. Methods A questionnaire was developed through a literature review consultation clinicians neurologists. Based on questionnaire, 40 consecutive were asked series Yes/No questions regarding 20 since onset PD. If participants answered ‘Yes’, they then detail their...
Myotonic dystrophy Type 1 (DM1) is caused by the expansion of CTG repeats (CTGn) in DM1 protein kinase (DMPK) gene, while it remains unclear whether CTGn may be associated with incidence cardiac events or sudden death Japan as well Europe. The aim this study was to investigate association between and involvements.
<h3>BACKGROUND:</h3> Manually-assisted coughing and mechanical insufflation-exsufflation (MI-E) are commonly used in patients with Duchenne muscular dystrophy (DMD). Few studies have compared cough peak flow (CPF) manually-assisted to other methods, such as MI-E + coughing. In addition, few reported the reliability of measured CPF values. This study aimed compare different cough-assistance methods examine data. <h3>METHODS:</h3> The included 12 subjects DMD (mean age, 34 ± 8 y). CPF,...
To investigate the clinical range of spinocerebellar ataxia type 6 (SCA6), we screened CAG repeat expansion in voltage-dependent alpha 1A calcium channel gene (CACNL1A4) 71 ataxic patients 60 families; 54 43 families with hereditary and 17 sporadic patients. Thirteen SCA6 were detected to have elongated CACNL1A4. Of these, 7 had been diagnosed as having cerebellar cortical atrophy, found occurrence. One patient showed distinct pontine atrophy prominent horizontal or oblique gaze nystagmus...
Abstract Polyglutamine (polyQ) aggregate bodies are a hallmark of dentatorubral‐pallidoluysian atrophy and related neurodegenerative disorders, although the relationship between body formation cell death is not clear. We analyzed kinetics polyQ time intervals for death, tracking individual cells using fluorescence video microscopy, first time. Expanded tracts atrophin‐1 with or without nuclear localization signal (NLS) labeled green fluorescent protein (GFP) were constructed, Q57NLS/GFP...