A5071099737- Muscle Physiology and Disorders
- Cardiovascular Function and Risk Factors
- Cardiac electrophysiology and arrhythmias
- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- Cardiac Arrhythmias and Treatments
- Genetic Neurodegenerative Diseases
- Cardiac pacing and defibrillation studies
- Mitochondrial Function and Pathology
- Ion Channels and Receptors
- Cardiovascular Syncope and Autonomic Disorders
- Inflammatory Myopathies and Dermatomyositis
- Neurogenetic and Muscular Disorders Research
- Parkinson's Disease Mechanisms and Treatments
- Pericarditis and Cardiac Tamponade
- Heart Rate Variability and Autonomic Control
- Cardiac Imaging and Diagnostics
- Calpain Protease Function and Regulation
- Coenzyme Q10 studies and effects
- Systemic Lupus Erythematosus Research
- Cardiac tumors and thrombi
- Aortic Thrombus and Embolism
- Facial Nerve Paralysis Treatment and Research
- Renal and Vascular Pathologies
- Chronic Kidney Disease and Diabetes
National Center of Neurology and Psychiatry
2015-2025
Tokyo National Hospital
2017-2021
Social Insurance Saitama Chuo Hospital
1988-1999
Saitama Medical University
1988-1999
Objectives: Comorbid diabetes is an important factor in the treatment of major psychiatric disorders. However, a substantial proportion diabetic patients remain undetected by routine indices such as blood glucose and HbA1c. This study tried to estimate rates unidentified or prediabetic using 75 g oral tolerance test (OGTT). Methods: Participants were 25 with depressive disorder (MDD), 28 bipolar (BP), 26 schizophrenia, psychiatrically normal controls. They all Japanese, showed non-diabetic...
ABSTRACT Introduction : Little is known about the frequency of cardiopulmonary failure in limb‐girdle muscular dystrophy type 2A (calpainopathy) patients, although some studies have reported severe cardiomyopathy or respiratory failure. Methods To clarify dysfunction this patient population, we retrospectively reviewed and cardiac function 43 patients with calpainopathy. Results Nine had forced vital capacity (FVC) < 80%, 3 used noninvasive positive pressure ventilation. Mean FVC was...
Emerging concerns regarding heart failure, arrhythmia, and sudden death in patients with muscular dystrophy are of significant clinical importance. On the other hand, little attention has been paid to renal dysfunction because these have low serum creatinine levels. Serum cystatin C, unaffected by muscle quantity, is a potentially superior marker for estimating function. Here, we present cases which estimated glomerular filtration rate (GFR) C (eGFRcys) provided good agreement simultaneously...
We retrospectively reviewed respiratory and cardiac function in patients with dysferlinopathy, including 2 autopsy cases dysfunction.Subjects included 48 who underwent evaluation (n = 47), electrocardiography 46), echocardiography 23).Of the 47 patients, 10 had reduced percent forced vital capacity (%FVC), 4 required non-invasive positive pressure ventilation. %FVC was significantly correlated disease duration, mean lower non-ambulatory as well those aged ≥65 years normal creatine kinase...
Myotonic dystrophy Type 1 (DM1) is caused by the expansion of CTG repeats (CTGn) in DM1 protein kinase (DMPK) gene, while it remains unclear whether CTGn may be associated with incidence cardiac events or sudden death Japan as well Europe. The aim this study was to investigate association between and involvements.
Flecainide and pilsicainide, Class IC antiarrhythmic drugs with slow kinetics, were administered to a 64-year-old man experiencing ventricular tachycardia. Both suppressed the arrhythmia, but caused ST segment elevation in leads II, III, aVF. No evidence of ischemic heart disease was detected. Withdrawal eliminated change. Because these frequently are used treat tachyarrhythmias patients who may present chest pain, this rare ECG manifestation should be recognized avoid misdiagnosis acute...
Background Myotonic dystrophy type 1 involves cardiac conduction disorders. Cardiac disease can cause fatal arrhythmias or sudden death in patients with myotonic 1. Methods and Results This study enrolled 506 (aged ≥15 years; >50 cytosine-thymine-guanine repeats) was treated 9 Japanese hospitals for neuromuscular diseases from January 2006 to August 2016. We investigated genetic clinical backgrounds including health care, activities of daily living, dietary intake, involvement, respiratory...
We previously identified UDP-N-acetylglucosamine 2-epimerase (GNE) myopathy patients with sleep apnea and a past history of thrombocytopenia, but without disease-specific cardiac involvement. This study aimed to clarify the occurrence, severity, serial changes these complications.Thirty-three genetically confirmed GNE who participated in 5-y longitudinal observational underwent platelet count platelet-associated immunoglobulin G (PA-IgG) measurements, study, electrocardiography (ECG), Holter...
The majority of patients with Duchenne muscular dystrophy (DMD) have electrocardiographic abnormalities, but the clinical significance conduction disturbances remains unclear. This study aimed to evaluate age-dependent cardiac by electrocardiogram (ECG) identify risks complete atrioventricular (AV) block in this patient population. In total, 47 DMD (age, ≥20 ys) who recorded ECGs at our hospital from July 2015 June 2016 were included study. PR interval and QRS duration their previous...
Abstract Background The transient receptor potential cation channel subfamily V member 2 (TRPV2) is a stretch-sensitive calcium channel. TRPV2 overexpression in the sarcolemma of skeletal and cardiac myocytes causes influx into cytoplasm, which triggers myocyte degeneration. In animal models cardiomyopathy muscular dystrophy (MD), inhibition was effective against heart failure motor function. Our previous pilot study showed that tranilast, inhibitor, reduced brain natriuretic peptide (BNP)...
This study aimed to examine weather left ventricular end-diastolic diameter (LVDd) could predict mortality from heart failure in patients with Duchenne muscular dystrophy (DMD) receiving standard cardio-protective therapies.One hundred thirty-three DMD aged ≥10 years who underwent echocardiography 2011 2015 were included this and retrospectively followed until August 2018. Patients divided into two groups according LVDd at initial echocardiography: ≤ 54 mm (Group 1: n=119) ≥ 55 2: n=14). To...
A 35-year-old woman was hospitalized due to frequent attacks of syncope immediately after the ringing a bell or alarm clock. Her standard electrocardiograms showed long QT interval (QTc=0.56 s) with bizarre T-wave inversion in precordial leads. After admission, total 9 events were observed. Malignant ventricular tachyarrhythmia (torsade de pointes, flutter fibrillation) recorded during each episode, and DC shock required abolish such tachyarrhythmias on 3 occasions. On monitored...
Summary: Duchenne (DMD) and other forms of muscular dystrophy (MD) are collectively rare affect approx imately 20 per 100,000 people. The on-going development exon skipping novel therapies for DMD is expected to lead improvements in motor function prognosis. However, dysfunction with these associated the risk increase cardiac burden. Development improve function, therefore, an urgent issue. This single-arm, open-label, multicenter study will include patients MD aged 13 years or older....
TdP is a serious complication of AV block. We report case complete block with QT prolongation who had bouts resistant to lidocaine and isoproterenol. Temporary pacing could not be performed, because insertion lead triggered that deteriorated into ventricular fibrillation. Nicorandil, potassium channel opener, shortened the interval abolished TdP. This may suggest opening drugs are clinically effective against associated bradycardia‐dependent prolongation.
We present a case of schizophrenia comorbid for tetralogy Fallot, without chromosome 22q.11.2 deletion or duplication, treated successfully with combination clozapine and antiepileptic drugs. Although by itself initially triggered convulsive seizures, we continued it co-administration valproate topiramate. This combined treatment did not affect cardiac function the patient, who experienced favorable clinical course in terms symptomatology functional outcomes. To our knowledge, provide first...
Background: Few studies have examined respiratory dysfunction in patients with Becker muscular dystrophy (BMD). Objective: This study aimed to examine the characteristics of BMD. Methods: The present retrospective assessed parameters adult BMD using medical records and compared these various patient identify correlations. aged 17 years older who had been diagnosed genetically and/or pathologically were included analysis. Results: Of source population 133 patients, function was 85. Two no...
てんかん患者における予期せぬ突然死は、SUDEP（sudden unexpected death in epilepsy）と呼ばれ、近年注目をあびている。我々は、終夜睡眠ポリグラフィ検査（PSG）中に複雑部分発作に伴う発作性心停止を呈したてんかん患者を経験したので報告する。症例は66歳女性。10歳で全身のけいれん発作が出現し、54歳以降は全身のけいれん発作は消失した。66歳で夜間にベランダに出る異常行動を認め、睡眠時随伴症疑いでPSGを行った。中枢性無呼吸に続き、脳波上広汎性の高振幅徐波、続いて15秒の心停止を認めた。その間、患者は側仰位で目を開閉するのみであった。複雑部分発作に伴う発作性心停止と考え、抗てんかん薬の調整を行った。本症例のように、けいれんでなく複雑部分発作時にも発作性心停止が併発するおそれに留意する必要がある。その上で、てんかん患者のPSGや長時間ビデオ脳波検査では、SUDEPのリスク軽減目的で、充分な観察やSpO2モニター、ECGアラームの設置が重要と考えた。
Accumulating evidence suggests that there is a bidirectional association between major depressive disorder (MDD) and type 2 diabetes mellitus.To elucidate impaired glycemic control in MDD more detail, we conducted the five-hour oral glucose tolerance test (OGTT) patients with MDD.Methods: Twenty-five outpatients DSM-IV were recruited into study along 28 controls.A 5-hour OGTT using 75 g of was employed to assess regulation based on blood samples.Samples drawn nine times pressure, heart rate...