Sandra M. Lopez

ORCID: 0009-0003-2940-8624
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About
Contact & Profiles
Research Areas
  • Estrogen and related hormone effects
  • Prostate Cancer Treatment and Research
  • Psychoanalysis and Psychopathology Research
  • Heart Failure Treatment and Management
  • PI3K/AKT/mTOR signaling in cancer
  • Ubiquitin and proteasome pathways
  • Disaster Response and Management
  • Hematological disorders and diagnostics
  • Protein Tyrosine Phosphatases
  • Psychotherapy Techniques and Applications
  • Philosophy, Sociology, Political Theory
  • Respiratory Support and Mechanisms
  • Receptor Mechanisms and Signaling
  • Trauma and Emergency Care Studies
  • Electrolyte and hormonal disorders
  • Therapeutic Uses of Natural Elements
  • Myofascial pain diagnosis and treatment
  • Bacterial Identification and Susceptibility Testing
  • Educational methodologies and cognitive development
  • Medical research and treatments
  • PARP inhibition in cancer therapy
  • Heat shock proteins research
  • Cardiovascular Function and Risk Factors
  • Mathematical Biology Tumor Growth
  • Neonatal and Maternal Infections

Memorial Healthcare System
2024-2025

Rafael Advanced Defense Systems (Israel)
2025

Hospital Pediátrico Moctezuma
2024

Institut Guttmann
2024

Universitat Autònoma de Barcelona
2024

Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol
2024

Johns Hopkins University
2016-2023

Florida International University
2010-2023

Universidad de Salamanca
2023

Johns Hopkins Medicine
2021-2023

While mild or moderate iron-deficiency anemia may not cause any symptoms, more severe deficiencies present clinically as fatigue, shortness of breath, exertional dyspnea, lightheadedness, tachycardia, and presyncope syncope, and, in rare instances, pica. Pica is defined the developmentally inappropriate ingestion non-nutritive, non-food substances for than one month. We case a duodenal obstruction secondary to pica-associated bezoar patient with who presented emergency department (ED)...

10.5811/cpcem.21300 article EN cc-by Clinical Practice and Cases in Emergency Medicine 2025-01-06

INPP4B and PTEN dual specificity phosphatases are frequently lost during progression of prostate cancer to metastatic disease. We others have previously shown that loss expression correlates with poor prognosis in multiple malignancies spread cancer. demonstrate de novo highly invasive human carcinoma PC-3 cells suppresses their invasion both vitro vivo. Using global gene analysis, we found regulates a number genes associated cell adhesion, the extracellular matrix, cytoskeleton....

10.1186/s12964-014-0061-y article EN cc-by Cell Communication and Signaling 2014-09-24

Castration therapy in advanced prostate cancer eventually fails and leads to the development of castration-resistant (CRPC), which has no cure. Characteristic features CRPC can be increased androgen receptor (AR) expression altered transcriptional output. We investigated nuclear corepressor 1 (NCOR1) human role NCOR1 response antiandrogens.NCOR1 protein levels were compared between matched normal 409 patient samples. knockdown was used investigate its effect on bicalutamide...

10.1158/1078-0432.ccr-15-1983 article EN Clinical Cancer Research 2016-03-12

Incorrect and excessive diagnosis of newborn infections in Nicaragua caused overcrowding the neonatal intensive care units unnecessary hospitalization. A baseline study nine hospitals found that none correctly utilized disinfectants, sterilization or hand hygiene sepsis was based primarily on clinical manifestations. In 2007, Ministry Health (MINSA), with Unites States Agency for International Development technical assistance, began developing guidelines implementing quality improvement...

10.1093/intqhc/mzt060 article EN International Journal for Quality in Health Care 2013-08-20

Fewer than half of children receive all recommended immunizations on time. Hospitalizations may be opportunities to address delayed immunizations. Our objectives were assess (1) prevalence among hospitalized patients, (2) missed administer immunizations, and (3) time catch up after discharge.We conducted a retrospective cohort study investigating immunization status patients 0 21 years age admitted an academic children's center from 2012 2013 at the admission, discharge, 18 months...

10.1542/hpeds.2018-0180 article EN Hospital Pediatrics 2019-09-01

A survey was conducted in a public, research university located large and diverse metropolitan area the southeastern part of USA. The purpose to determine both positive negative personal, educational, social, work related consequences playing video games. Nearly two‐thirds 203 participants this study were Hispanic heritage. majority sample derived using school intercept, as opposed mall strategy. remaining obtained snowball, convenience sampling techniques. Statistically significant...

10.1080/09523987.2010.535338 article EN Educational Media International 2010-12-01

Levosimendan is an inotropic seldom used in emergency departments (EDs). It has shown improved mortality patients with shock [1] few adverse effects [2]. This work denotes the experience of levosimendan use ED Hospital Universitario Mayor between 2012 and 2014.

10.1186/cc14233 article EN cc-by Critical Care 2015-03-16

Community integration (CI) is a crucial rehabilitation goal after spinal cord injury (SCI). There pressing need to enhance our understanding of the factors associated with CI for individuals traumatic or non-traumatic etiologies, latter being notably understudied. Accordingly, research explores associations and potential mediators influencing across these populations.

10.1080/10790268.2024.2386738 article EN Journal of Spinal Cord Medicine 2024-08-12

One approach for mitigation of stainless steel (SS) spent fuel canisters (SFCs) is to coat the welds or even entire SFC with a cold-sprayed nickel coating. The coating can serve as magnetostrictive interface between an electromagnetic acoustic transducer (EMAT) and SS plate material. EMAT send ultrasound into canister “listen” reflections caused by chloride-initiated stress corrosion cracking (CISCC) other damage mechanisms that may lead leaks if undetected unmitigated. This project outlines...

10.32548/2024.me-04423 article EN Materials Evaluation 2024-10-01

Background Community-acquired bacteremia is a potential source of infection and cause fever in patients presenting to the emergency department (ED) with suspected sepsis. Ambiguous or false-positive blood culture results may lead unnecessary testing overtreatment substantial implications on antimicrobial stewardship associated healthcare costs. There little clinical information available determine high degree certainty whether patient be febrile secondary bacteremia. The primary aim this...

10.7759/cureus.72561 article EN Cureus 2024-10-28

<titre>Résumé</titre>Nous mettons en travail quelques réflexions autour du corps des co-thérapeutes dans un psychodrame psychanalytique individuel pour adolescents. Nous tentons de montrer comment l’éprouvé corporel co-thérapeute donne naissance à représentations psychiques qui peuvent être au service jeu psychodramatique. nous interrogeons également sur les difficultés d’un processus soins implique l’engagement tout entier. discutons enfin indications thérapeutiques une telle prise charge...

10.3917/ado.052.0427 article FR Adolescence 2005-01-01

INPP4B and PTEN dual specificity phosphatases are frequently lost during progression of prostate cancer to metastatic disease. We others have previously shown that loss expression correlates with poor prognosis in multiple malignancies spread cancer. demonstrate de novo highly invasive human carcinoma PC-3 cells suppresses their invasion both vitro vivo. Using global gene analysis, we found regulates a number genes associated cell adhesion, the extracellular matrix, cytoskeleton....

10.1186/preaccept-2663637391256502 article EN cc-by Cell Communication and Signaling 2014-01-01

Abstract Breast cancer cell proliferation results from many different factors that activate multiple cellular signaling pathways, which are currently target therapies. Yet, how genomic pathways influenced upon cell-signaling disruption has been poorly assessed. We explored the inhibition of HER2 pathway influences function transcription factor FOXA1. By means specific inhibitors targeting kinase activity (Lapatinib) and its downstream MEK (AZD6244) we have identified HER2/MEK as a key...

10.1158/1535-7163.targ-13-b124 article EN Molecular Cancer Therapeutics 2013-11-01
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