A5101973444- Acute Kidney Injury Research
- Pediatric Hepatobiliary Diseases and Treatments
- Chronic Kidney Disease and Diabetes
- Folate and B Vitamins Research
- Advanced Image and Video Retrieval Techniques
- Dialysis and Renal Disease Management
- Pregnancy and preeclampsia studies
- Gout, Hyperuricemia, Uric Acid
- Vaccine Coverage and Hesitancy
- Birth, Development, and Health
- Anesthesia and Neurotoxicity Research
- Preterm Birth and Chorioamnionitis
- Groundwater flow and contamination studies
- Geophysical and Geoelectrical Methods
- Pregnancy and Medication Impact
- Metabolism and Genetic Disorders
- Diabetes Treatment and Management
- Pharmacological Effects of Natural Compounds
- Neurological Disease Mechanisms and Treatments
- Organ Transplantation Techniques and Outcomes
- Sulfur Compounds in Biology
- Trace Elements in Health
- Neonatal Respiratory Health Research
- Electrical and Bioimpedance Tomography
- Reproductive System and Pregnancy
Shaoxing People's Hospital
2021-2025
Longgang Central Hospital
2020-2024
State Key Laboratory of Vehicle NVH and Safety Technology
2021-2022
Sichuan University
2002-2022
West China Hospital of Sichuan University
2017-2022
Beijing Institute of Technology
2022
Beijing University of Technology
2022
Shanghai Xuhui Central Hospital
2022
Fudan University
2022
Shanghai Clinical Research Center
2022
Aims: Ischemia-reperfusion injury (IRI)-induced acute kidney (IRI-AKI) is characterized by elevated levels of reactive oxygen species (ROS), mitochondrial dysfunction, and inflammation, but the potential link among these features remains unclear. In this study, we aimed to investigate specific role ROS (mtROS) in initiating DNA (mtDNA) damage inflammation during IRI-AKI. Methods: The changes renal function, IRI-AKI mice with or without mtROS inhibition were analyzed vivo. impact on TFAM...
Hydraulic tomography (i.e., a sequential aquifer test) has recently been proposed as method for characterizing heterogeneity. During hydraulic experiment, water is sequentially pumped from or injected into an at different vertical portions intervals of the aquifer. each pumping injection, head responses other are monitored, yielding set head/discharge (or recharge) data. By injecting) one interval and monitoring steady state others, many (recharge) data sets obtained. In this study inverse...
Two sandbox experiments were conducted to evaluate the performance of a sequential geostatistical inverse approach for hydraulic tomography in characterizing aquifer heterogeneity. One was packed with layered sands represent stratified aquifer, while other discontinuous sand bodies different shapes and sizes more complex realistic heterogeneous aquifer. Parallel experiments, numerical assess effects measurement errors uncertainties associated laboratory data, diagnose conductivity estimates...
Increasing evidence indicates that obesity is highly associated with chronic kidney disease (CKD). GLP-1 receptor (GLP-1R) agonist has shown benefits on diseases, but its direct role metabolism in still not clear. This study aims to investigate the protection and metabolic modulation of liraglutide (Lira) obesity. Rats were induced obese by high-fat diet (HFD), renal function changes evaluated metabolomic, biological histological methods. HFD rats exhibited systemic disorders such as...
Hydrogen sulfide (H2S) is a crucial signaling molecule with wide range of physiological functions. Previously, we confirmed that stress-induced depression accompanied disturbance H2S generation in hippocampus. The present work attempted to investigate the inhibitory effect on chronic unpredictable mild depressive-like behaviors and underlying mechanism. We established rat model stress simulate depression. Open field test, forced swim tail suspension test were used assess behaviors....
Abstract Hyperuricemia is an important risk factor for cardiovascular and renal diseases. Phloretin had shown antioxidant anti‐inflammatory properties, but its role in endothelial injury rarely reported. In this study, we aimed to investigate the protective effect of phloretin on UA ‐induced human umbilical vein cells. The effects cell viability, inflammation, THP ‐1 monocyte adhesion, tube formation, GLUT 9 expression uptake cells were evaluated. changes nuclear factor‐kappa B/extracellular...
Abstract Diabetic kidney disease (DKD) is a severe DM complication. While complement C5 up‐regulation and gut dysbiosis are found in T2DM, their roles DKD unclear. Here, we investigated the effect of on microbiota during development. Renal C5a/C5a receptor (C5aR) expression changes were measured T2DM patients db/db mice. Db/db mice treated with C5aR antagonist (C5aRA), renal function, genome analysed. The effects C5a short‐chain fatty acids (SCFAs) signal transducer activator transcription 3...
Persistent mitochondrial injury occurs after acute kidney (AKI) and mitochondria-targeted antioxidant Mito-2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO) (MT) has shown benefits for AKI, but its efficiency is limited by short half-life side effect in vivo. Self-assembling peptide (SAP) hydrogel a robust platform drug delivery. This study aims to develop an SAP-based carrier slow release MT enhancing long-term therapeutic potency on AKI. The KLD with aspartic acid (KLDD) was designed....
Objective: To investigate the effects of targeting PI3K-mTOR signaling pathway in anterior cingulate cortex (ACC) on pain responses, locomotor activity, and emotional behavior rats with bone cancer pain. Methods: Bone was induced by implanting Walker 256 cells into rat. Pain responses were assessed using paw withdrawal threshold latency measurements, while activity negative mood evaluated through open field conditioned place aversion tests, respectively. Results: The results showed that...
Objective The objective of this study was to define the threatened perception types pregnant women during COVID-19 pandemic and determine correlations between their demographic factors, preventive knowledge mental status in order provide suggestions for pandemic. Methods Latent class analysis were used explore optimal numbers clusters. Multinomial logistic regression multiple correspondence analyze variables latent categories. MANOVA difference obtained among clusters psychological status,...
Visceral adipose tissue (VAT) and hepatic fat deposition are the most important risk factors for women's health. Acupuncture, including electroacupuncture (EA), is used to treat obesity throughout world. The effect of EA evaluated mainly by body mass index (BMI) waist circumference (WC). Few studies have assessed its in reducing VAT volume fraction (HFF) based on an exact measurement method such as magnetic resonance imaging (MRI). This study aimed resolve this issue.Thirty subjects were...
Abstract Haemoglobin A1c (HbA1c) is a marker of glycaemic control in type 2 diabetes mellitus (T2DM). Increased waist circumference (WC) known to be associated with T2DM. Therefore, we investigated the relationship WC HbA1c and explored its optimal cutoff for identifying prediabetes risk. This study included 2339 participants between 18 84 years age [mean (SD) age, 43.5 (11.9) years] valid data on WC, related variables Shenzhen–Hong Kong United Network Cardiovascular Disease study....
Introduction Beta-2-microglobulin (B2M), cystatin C and lipocalin-2 (LCN-2) are established renal biomarkers, yet their roles in stroke have not been fully evaluated. We aimed to investigate the relationship of B2M, C, LCN-2 with risk a general Chinese population.Methods used ordinal regression study between serum 1060 participants (mean age 45.4 ± 10.8 years, 46% male) from Shenzhen-Hong Kong United Network on Cardiovascular Disease (SHUN-CVD) study. Stroke was classified into low-risk,...
Abstract Background Irregular sleep patterns have been associated with inflammation. Galectin-3, a novel biomarker, plays an important role in We investigated the relationship between and galectin-3 Chinese population. Methods A total of 1,058 participants from Shenzhen-Hong Kong United Network on Cardiovascular Disease study were included analysis. Age sex-adjusted linear regression models employed to investigate level traditional metabolic biomarkers. Logistic used estimate association...
The World Health Organization (WHO) proposed COVID-19 vaccination as an emergent and important method to end the pandemic. Since China started programs in December 2020, has spread provinces municipalities nationwide. Previous research focused on people's willingness its influencing factors but not examined behavior. We examine effectiveness of psychosocial predicting