Abstract Purpose: Studying the effect of interleukin-17 (IL-17) on mechanism CD4+ T-cell immune regulation and Janus kinase/signal transducer activator transcription (JAK/STAT) pathway may offer new ideas methods for therapy dilated cardiomyopathy. Methods: Naive T cells were isolated from mice using a magnetic bead sorting reagent manipulated by overexpression or knockdown IL-17. Protein levels kinase 2 (JAK2), phosphorylated JAK2 (p-JAK2), signal 3 (STAT3), STAT3 (p-STAT3), matrix...

Abstract Objective The aim of this study was to search for key genes in ankylosing spondylitis (AS) through comprehensive bioinformatics analysis, thus providing some theoretical support future diagnosis and treatment AS further research. Methods Gene expression profiles were collected from Expression Omnibus (GEO, http://www.ncbi.nlm.nih.gov/geo/ ) by searching the term "ankylosing spondylitis". Ultimately, two microarray datasets (GSE73754 GSE11886) downloaded GEO database. A bioinformatic...

Teachers play a critical role in the preparation of future science, technology, engineering, and mathematics majors professionals. What teachers know about their discipline (i.e., content knowledge) has been identified as an important aspect instructional effectiveness; however, studies have not yet assessed knowledge aspiring chemistry United States. The Praxis Chemistry Subject Assessment is most nationally representative measure teacher knowledge, used 39 U.S. states past decade. In...

A generally agreed upon tenant of the physics teaching community is centrality subject-specific expertise in effective teaching. However, studies which assess content knowledge incoming K–12 teachers U.S. have not yet been reported. Similarly lacking are on if or how demographic makeup aspiring educators different from previously reported analyses actual high school workforce. Here we present findings about demographics and subject prospective using data Praxis assessments administered...

What teachers know about their content area plays a role in how they effectively enhance the scientific literacy of students. This leads to questions teacher knowledge as enter field. The Praxis Earth and Space Science: Content Knowledge Test is most widely used licensure assessment for aspiring science United States. There are few previous reports on personal professional characteristics those test-takers which would provide information candidates. study presents findings based analysis...

In the current economic environment, cost control has become focus of every business operation. On premise that load resources owned by user have depreciation or transfer costs, benefits demand response project are driving factors for to consider whether participate. The cost-benefit analysis method is taken evaluate potential, and potential type divided into permanently saved temporary adjustable load. Energy saving upgrading electrical equipment infrastructure used assess compare unit...

With the acceleration of power grid construction, scale electricity continues to expand, and mileage distribution lines is also constantly increasing. The are exposed natural environment for a long time require regular inspections eliminate hidden dangers, defect detection equipment has become key link in ensuring stable operation system. deep application drones field development artificial intelligence technology, using inspect collect line images gradually mainstream. Infrared imaging...

Due to shortage of water resources and increasing demands, the joint operation multireservoir systems for balancing power generation, ecological protection, residential supply has become a critical issue in hydropower management. However, numerous constraints nonlinearity multiple reservoirs make solving this problem time-consuming. To address challenge, deep reinforcement learning approach that incorporates transformer framework is proposed. The multihead attention mechanism encoder...

Teacher content knowledge has been identified as a key prerequisite to effective instruction, and current educational policies require measurement of teacher assess candidacy for licensure. The primary instruments used in the United States are Praxis Subject Assessment exams, which designed measure subject-specific needed be teacher. Biology exam, by 42 U.S. states past decade, is most common national determine biology certification. Demographic performance data from examinees (N = 43,798)...

Identification of differential gene regulators with significant changes under disparate conditions is essential to understand complex biological mechanism in a disease. Differential Network Analysis (DiNA) examines different processes based on regulatory networks that represent interactions between genes graph model. While most studies DiNA have considered correlation-based inference construct from expression data due its intuitive representation and simple implementation, the approach lacks...

Objective To investigate the interest, cognition degree, participation degree and current situation of advanced undergraduate clinical students in our college, to discuss reason for low level students' scientific research quality, order provide reference making training program s them. Methods The undergraduates seven-year five-year interned orthopedics department from January June 2014 were selected with cluster sampling method, investigated anonymously by questionnaires interview....

Constructivism teaching theory emphasizes the central role of student in learning and this theoretical framework holds that always builds upon active exploring discovering new knowledge.Department orthopedics first affiliated hospital Chongqing Medical University introduced implemented constructivism teachers' research activity as well students' learning.This mobilized enthusiasm improved clinical quality. Key words: Constructivism; Orthopedic teaching; Teaching quality

Abstract Objective: The aim of this study is to search for key genes in ankylosing spondylitis through comprehensive bioinformatics analysis, thus providing some theoretical support future diagnosis and treatment AS further research. Methods: expression matrix was downloaded integrated public libraries. A bioinformatic approach used screen differential perform functional enrichment analysis obtain biological functions signaling pathways associated with the disease. Weighted correlation...