A5081762808- Transplantation: Methods and Outcomes
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Enhanced Recovery After Surgery
- Xenotransplantation and immune response
- Cardiac, Anesthesia and Surgical Outcomes
- Food Allergy and Anaphylaxis Research
- Immunotherapy and Immune Responses
- Renal Transplantation Outcomes and Treatments
- Dermatology and Skin Diseases
- Cardiac Structural Anomalies and Repair
- Drug-Induced Hepatotoxicity and Protection
- Pneumocystis jirovecii pneumonia detection and treatment
- Cytomegalovirus and herpesvirus research
- Vascular Procedures and Complications
- Urticaria and Related Conditions
- Hematopoietic Stem Cell Transplantation
- Mechanical Circulatory Support Devices
- Immunodeficiency and Autoimmune Disorders
- Pharmacological Effects and Toxicity Studies
- Metabolism and Genetic Disorders
- Central Venous Catheters and Hemodialysis
- Hip and Femur Fractures
- Nutrition and Health in Aging
- Hemodynamic Monitoring and Therapy
Institut d'Investigació Biomédica de Bellvitge
2024
Bellvitge University Hospital
2024
Universitat de Barcelona
2024
Hospital General Universitario Gregorio Marañón
2017-2023
Hospital Materno-Infantil
2022
Abstract CD25, the alpha chain of IL-2 receptor, is expressed on activated effector T cells that mediate immune graft damage. Induction immunosuppression commonly used in solid organ transplantation and can include antibodies blocking CD25. However, regulatory (Tregs) also rely CD25 for their proliferation, survival, function. Therefore, CD25-blockade may compromise Treg protective role against rejection. We analysed vitro effect basiliximab (BXM) viability, phenotype, proliferation cytokine...
Due to their suppressive capacity, regulatory T cells (Tregs) have attracted growing interest as an adoptive cellular therapy for the prevention of allograft rejection, but limited Treg recovery and lower quality adult-derived Tregs could represent obstacle success. To address this challenge, we developed a new approach that provides large quantities with high purity excellent features, sourced from thymic tissue routinely removed during pediatric cardiac surgeries (thyTregs). We report on...
Due to their suppressive capacity, the adoptive transfer of regulatory T cells (Treg) has acquired a growing interest in controlling exacerbated inflammatory responses. Limited Treg recovery and reduced quality remain main obstacles most current protocols where differentiated are obtained from adult peripheral blood. An alternate source is umbilical cord blood, promising due higher frequency naïve lower memory present fetus’ However, number isolated blood remains limiting. Human thymuses...
Atopic dermatitis (AD) has a high incidence in heart-transplant children, and the reason why there is more AD after transplantation still unknown. We conducted cross-sectional study comparing 11 non-AD age-matched to assess which immune alterations are related these patients. patients had been transplanted at younger age compared non-AD, indicating that transplant may be determinant onset of AD. The earlier thymectomy children favored presence differentiated phenotypes T cell compartment....
Regulatory T cells (Treg) are crucial for the induction and maintenance of graft tolerance. In pediatric heart transplant procedures, thymus is routinely excised, removing primary source T-cell replenishment. Consequently, thymectomy joined to effects immunosuppression on compartment may have a detrimental impact Treg values, compromising intrinsic tolerance mechanisms protective role preventing rejection in children.A prospective study including 7 children was performed, immune cell...
Abstract Evidence on the impact of MCS pediatric heart transplant survival is still scarce related to congenital disease patients including univentricular physiology as well risk factors for complications. We performed a retrospective review all urgent (aged ≤16 years) HT from 2004 2014 in Spanish Pediatric Heart Transplant Registry Group. Patients were stratified into two groups: 0 (MCS at HT) and 1 (non‐MCS HT). The primary outcome measure was post‐transplant survival; secondary measures...
Immune allograft rejection remains the main obstacle to reach successful transplants. Transfer of regulatory T cells (Treg) has acquired growing interest in attempts prevent rejection. However, limited number and differentiated phenotype Tregs isolated from blood constitute important drawbacks for effectiveness this strategy. In collaboration with several teams, we have explored use thymic tissue, which is routinely discarded during pediatric cardiac surgery, as an alternative source be used...
<h3>Introduction/Background</h3> Enhanced Recovery After Surgery (ERAS) protocol is a comprehensive transformation of the surgical process that have revolutionised postoperative care across various specialties. Beyond implementation ERAS, we designed complete change with aim improving, not only quantitative results (stays, complications) but qualitative (both satisfaction patients and professionals). For that, obtained European grant (FEDER-RISC3CAT) €1,134,000, which involved purchase...
<h3>Introduction/Background</h3> Beyond implementation of ERAS (Enhaced Recovery After Surgery), we designed a complete change the surgical process with aim improving, not only quantitative results (stays, complications) but qualitative (both satisfaction patients and professionals). For that, obtained European grant (FEDER-RISC3CAT) €1,134,000, which involved purchase materials, devices, shared risk consultancy MEDTRONIC (Data Project manager). <h3>Methodology</h3> To analyse basal...
<h3>Introduction/Background</h3> Beyond implementation of ERAS (Enhaced Recovery After Surgery), we designed a complete change the surgical process with aim improving, not only quantitative results (stays, complications) but qualitative (both satisfaction patients and professionals). For that, obtained European grant (FEDER-RISC3CAT) €1,134,000, which involved purchase materials, devices, shared risk consultancy MEDTRONIC (Data Project manager) for whole new process, including...
Abstract Peripheral venous catheters (PVCs) are frequently inserted in children. However, their use is associated with difficulties during insertion and complications management. Our objective was to assess an interventional care bundle for of PVCs pediatric patients admitted a cardiology department. Over 10-month period, we prospectively included PVC the The study period comprised 4-month pre-intervention followed by 6-month post-intervention which preventive implemented. Data regarding...
Introduction: Immune allograft rejection remains the main obstacle to successful transplants. Due their suppressive capacity, regulatory T cell (Treg) therapy is a very promising alternative prevent and achieve indefinite graft survival. Several clinical trials conducted in adults with peripheral blood Treg demonstrate safety of therapy, although its efficacy seems be limited. To overcome current barriers make this effective, we explore pioneering strategy that employs, as an source cells,...
Introduction: Following transplantation, many transplant programs employ induction immunosuppression, a relatively intense prophylactic therapy used at the time of to prevent early acute rejection. Of drugs, interleukin-2 receptor (CD25) antagonist basiliximab (BXM) is frequently used. The targets BXM are activated effector T cells, that upregulate CD25 upon activation and undergo IL-2 mediated T-cell proliferation, compromising allograft survival [1]. However, regulatory cells (Treg) also...
Introduction Heart transplantation is a successful strategy for the treatment of end-stage pediatric heart diseases. In recent years, improved therapies and clinical practice have led to increased graft survival, consequently, chronic complications secondary organ due in part long-term immunosuppression also emerged. Allergies atopic diseases, such as dermatitis (AD) are among these complications. Despite that AD constitutes frequent comorbidity transplantation, little known about immune...
Introduction: Immune allograft rejection remains the main obstacle to successful transplants. Due their suppressive capacity, adoptive transfer of regulatory T cells (Treg) has acquired growing interest in achieving indefinite graft survival. Limited Treg recovery and reduced quality remain obstacles current protocols where are obtained from adult peripheral blood. We have developed a novel GMP-compatible protocol using thymus routinely discarded during pediatric cardiac surgeries as source,...