A5034675251- Total Knee Arthroplasty Outcomes
- Lower Extremity Biomechanics and Pathologies
- Osteoarthritis Treatment and Mechanisms
- Knee injuries and reconstruction techniques
- Sports injuries and prevention
- Orthopaedic implants and arthroplasty
- Sports Dynamics and Biomechanics
- Antibiotic Resistance in Bacteria
- Sports Performance and Training
- Trace Elements in Health
- Orthopedic Infections and Treatments
- Cardiac Arrhythmias and Treatments
- Biological Activity of Diterpenoids and Biflavonoids
- Salmonella and Campylobacter epidemiology
- Hip disorders and treatments
- Atrial Fibrillation Management and Outcomes
- Escherichia coli research studies
- Bone fractures and treatments
- Mycorrhizal Fungi and Plant Interactions
- Pharmaceutical and Antibiotic Environmental Impacts
- Plant-based Medicinal Research
- Medicinal Plant Pharmacodynamics Research
- Biochemical Analysis and Sensing Techniques
- Medicinal plant effects and applications
- Fungal Biology and Applications
Kyoto University
1995-2025
Niigata University of Health and Welfare
2015-2024
Niigata Institute of Technology
2006-2020
University College London
2019
Thrombosis Research Institute
2019
KLE Society Hospital
2018
Sir Ganga Ram Hospital
2018
Institute for Sports Medicine
2016
Osaka University
2010-2012
Japan Science and Technology Agency
2010
We previously demonstrated that brain natriuretic peptide (BNP) is a cardiac hormone mainly produced in the ventricle, while major production site of atrial (ANP) atrium. To assess pathophysiological role BNP ventricular overload, we have examined gene expression BNP, In comparison with ANP, model hypertrophy using cultured neonatal rat cardiocytes. During cardiocyte evoked by endothelin-1, Phenylephrine, or PMA, steady state level mRNA increased as rapidly "immediate-early" induction c-fos...
Zinc deficiency causes myriad pathophysiological symptoms, but why distinct phenotypes are generated by zinc remains unclear. Considering that several ectoenzymes involved in purinergic signaling through extracellular adenine-nucleotide hydrolysis possess ions their active sites, and disorders result diverse diseases frequently similar to those caused deficiency, herein we examine whether affects metabolism. severely impairs the activities of major (ENPP1, ENPP3, NT5E/CD73, TNAP), also...
Tryptase, which is abundant in human mast cells and involved allergic inflammations such as asthma, a serine protease. We isolated tryptase inhibitor, procyanidin B8 3,3′-di-O-gallate (PB8GG’), tannin, from the methanol extract of rhubarb (RHEI RHIDOMA), traditional Chinese medicine (Kampo Japan). Since it did not inhibit another protease trypsin, PB8GG’ specifically inhibited tryptase. A standard kinetic analysis inhibitory fashion against suggested that an allosteric manner. searched for...
Hfq is a bacterial RNA chaperone involved in the post-transcriptional regulation of many stress-inducible genes via small non-coding RNAs. Although related to important phenotypes including virulence pathogens, its role drug resistance unknown. The aim this study was investigate multidrug resistance. hfq gene inactivated Escherichia coli by use pKO3, which replacement vector. susceptibility and accumulation mutant were determined. level production AcrB efflux pump also measured. susceptible...
Several putative and proven drug efflux pumps are present in Escherichia coli. Because many such have overlapping substrate spectra, it is intriguing that bacteria, with their economically organized genomes, harbour large sets of multidrug genes. To understand how bacteria utilize these multiple pumps, important to elucidate the process pump expression regulation. The aim this study was determine a regulator organism. We screened genomic library E. coli for genes decreased susceptibility...
ObjectivesSalmonella enterica strains exhibiting decreased susceptibility to tigecycline have been reported. In this study, we sought elucidate the roles of Salmonella multidrug efflux pumps and AcrAB regulators in resistance.
The physiological roles of Zn transporter (ZNT) proteins are being increasingly recognized, and three dimensional structures ZNT bacterial homologs have facilitated our understanding their biochemical characteristics at the molecular level. However, biological role unique structural features vertebrate ZNTs, which absent in homologues, is not completely understood. These sequences include a cytosolic His-rich loop between transmembrane helices IV V N-terminus. This study investigated...
Tricholoma matsutake, a basidiomycete, forms ectomycorrhizas with Pinus densiflora as the host tree. Its fruiting body, "matsutake" in Japanese, is an edible and highly prized mushroom, it grows circle called fairy ring. Beneath ring of T. whitish mycelium-soil aggregated zone, "shiro" develops. The front shiro, active mycorrhizal functions to gather nutrients from soil roots nourish Bacteria sporulating fungi decrease shiro front, whereas they increase inside outside front. Ohara...
The extract of Salvia officinalis (Common Sage) exhibited inhibitory activity STAT3 signal after screening several plants extracts using the STAT3-responsive reporter system. Cirsiliol, luteolin, and carnosol were identified from methanol Silvia as inhibitors signaling effects these three compounds on protein or growth inhibition cancer cells was compared. Luteolin at dose 90 μM clearly suppressed phosphorylation induced by IL-6, while prone to decrease total proteins high doses (>90 μM)....
We aimed to clarify the effect of ball–racquet impact locations on dynamic behavior tennis racquet, accuracy shots and muscle activation forearm. Eight male intermediate players performed ten forehand groundstrokes. A motion capture system was used measure motions ball human body at 2000 Hz, electromyography (EMG) activities wrist extensor flexor muscles were measured simultaneously. The flight parameters by ballistic measurement equipment. All divided into tertiles based location along...
Background: Cathepsin K, which is involved in bone resorption, a good target for treating osteoporosis, but no clinically approved medicine has been developed. Recently, allosteric inhibitors with high specificity and few side effects have attracting attention use new medicines. Methods: K were isolated from the methanol extract of Chamaecrista nomame (Leguminosae) using cathepsin inhibition activity-assisted multi-step chromatography. Standard kinetic analysis was employed to examine...