A5103898825- Orthopedic Infections and Treatments
- Orthopaedic implants and arthroplasty
- Cardiac, Anesthesia and Surgical Outcomes
- Hip and Femur Fractures
- Total Knee Arthroplasty Outcomes
- Anesthesia and Pain Management
- Planetary Science and Exploration
- Traumatic Brain Injury and Neurovascular Disturbances
- Atomic and Subatomic Physics Research
- Space Exploration and Technology
- Advanced MRI Techniques and Applications
- Spaceflight effects on biology
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury Research
- Infectious Diseases and Tuberculosis
- Infective Endocarditis Diagnosis and Management
- Intensive Care Unit Cognitive Disorders
- Blood disorders and treatments
- Foreign Body Medical Cases
- Astro and Planetary Science
- Airway Management and Intubation Techniques
- Prostate Cancer Treatment and Research
- Protease and Inhibitor Mechanisms
- Anesthesia and Neurotoxicity Research
- Cardiac Arrest and Resuscitation
Medical University of Vienna
2021-2024
Innsbruck Medical University
2012-2022
Universität Innsbruck
2014-2022
University of Oxford
2022
Nuffield Orthopaedic Centre
2022
Oxford University Hospitals NHS Trust
2021
University Hospital Innsbruck
2017
Space Research Institute
2014
This study evaluated the definitions developed by European Bone and Joint Infection Society (EBJIS) 2021, International Consensus Meeting (ICM) 2018, Infectious Diseases of America (IDSA) 2013, for diagnosis periprosthetic joint infection (PJI).In this single-centre, retrospective analysis prospectively collected data, patients with an indicated revision surgery after a total hip or knee arthroplasty were included between 2015 2020. A standardized diagnostic workup was performed, identifying...
Aims The aim of this study was to evaluate the optimal deep tissue specimen sample number for histopathological analysis in diagnosis periprosthetic joint infection (PJI). Methods In retrospective diagnostic study, patients undergoing revision surgery after total hip or knee arthroplasty (n = 119) between January 2015 and July 2018 were included. Multiple specimens membrane pseudocapsule obtained at arthroplasty. Based on Infectious Diseases Society America (IDSA) 2013 criteria,...
Aims Histology is an established tool in diagnosing periprosthetic joint infections (PJIs). Different thresholds, using various infection definitions and histopathological criteria, have been described. This study determined the performance of different thresholds polymorphonuclear neutrophils (≥ 5 PMN/HPF, ≥ 10 23 PMN/10 HPF) , when European Bone Joint Infection Society (EBJIS), Infectious Diseases America (IDSA), International Consensus Meeting (ICM) 2018 criteria for PJI. Methods A total...
Background: High blood levels of the chemokine eotaxin-1 (CCL11) have recently been associated with ageing and dementia, as well impaired memory learning in humans. Importantly, was shown to pass blood-brain-barrier has identified crucial mediator decreased neurogenesis cognitive impairment young mice after being surgically connected vessel system old animals a parabiosis model. It thus be assumed that sudden changes between donors recipients might influence functions also However, it is...
We report on the MARS2013 mission, a 4-week Mars analog field test in northern Sahara. Nineteen experiments were conducted by crew Morocco under simulated martian surface exploration conditions, supervised Mission Support Center Innsbruck, Austria. A Remote Science team analyzed data near real time, providing planning input for management of complex system assets; two advanced space suit simulators, four robotic vehicles, an emergency shelter, and stationary sensor platform realistic work...
Purpose: The aim of our study was to investigate the clinical relevance preoperative acute pain management and cardiovascular stability by ultrasound-guided continuous 3-in-1 nerve block in very elderly patients with hip fracture when compared epidural anesthesia (PDA). Methods: To analgesic effect, we enrolled 37 fractures, whom 3 dementia had be excluded. Thus, 34 were randomized 1 groups: group A (ultrasound-guided block, bupivacaine; n = 10, dropout rate: 0), B (PDA, 14, 8), C (systemic...
Background: To investigate incidence and predictors of the various postoperative cognitive declines in old patients with hip fracture. Methods: This retrospective chart study evaluated 411 (age ≥80 years, follow-up 5 years). After exclusion 82 (preexisting dementia or delirium), 70 showing either diagnosed delirium (POD; group 1; N = 18, 5.5%) an unspecified dysfunction behavior (group 2; 52, 15.8%) were analyzed compared those without any acute cerebral impairment (control group; 259,...
INTRODUCTION AND OBJECTIVES Eotaxin-1 (CCL11) is a protein expressed in various tissues influencing immunoregulatory processes by acting as selective eosinophil chemo-attractant. In prostate cancer (PCa), the expression and functional role of CCL11 have not been intensively investigated so far. Therefore, aim present study was to investigate diagnostic or prognostic potential PCa patients. MATERIALS METHODS We analyzed serum from 140 patients who undergone biopsy due elevated...
The treatment of intracranial aneurysms may be associated with cerebral ischemia. We hypothesize that pre-interventional remote ischemic preconditioning (RIPC) reduces tissue damage in patients undergoing elective aneurysm treatment. This study is a single-center, prospective, randomized, double-blind explorative trial. Patients an unruptured admitted to Innsbruck Medical University Hospital for coiling or clipping will consecutively randomized either the intervention group (= RIPC by...
Aims Serum inflammatory parameters are widely used to aid in diagnosing a periprosthetic joint infection (PJI). Due their limited performances the literature, novel and more accurate biomarkers needed. albumin-to-globulin ratio (AGR) serum CRP-to-albumin (CAR) have previously been proposed as potential new parameters, but results were mixed. The aim of this study was assess diagnostic accuracy AGR CAR PJI compare them established marker CRP. Methods From 2015 2022, consecutive series 275...
We have developed a portable dual-wavelength laser fluorescence spectrometer as part of multi-instrument optical probe to characterize mineral, organic, and microbial species in extreme environments. Operating at 405 532 nm, the instrument was originally designed for use by human explorers produce laser-induced emission (L.I.F.E.) spectral database mineral organic molecules found communities Earth's cryosphere. Recently, our team had opportunity explore strengths limitations when it deployed...
Acute changes of cerebral energy metabolism in early brain injury (EBI) after aneurysmal subarachnoid hemorrhage (aSAH) may play a crucial role for overall neurological outcome. However, direct detection these alterations is limited. Phosphorous magnetic resonance spectroscopy (31P-MRS) molecular-based advanced neuroimaging technique allowing measurements pathophysiological processes and tissue based on various phosphorous compound metabolites. This method provide objective assessment both...
Introduction Early magnetic resonance imaging (MRI) provides indispensable information for management and prognosis in patients with severe traumatic brain injury (sTBI). Yet, optimal timing of MRI remains unknown. The aim our study was to evaluate the safety early identify a method appropriate patient selection minimize adverse events related intrahospital transport (IHT) examination. Methods Twenty-six sTBI (mean GCS 6, range 3-8) admitted neurosurgical ICU from 03/ 2015 12/2017 receiving...
The Ambu Aura Gain is a newer second-generation supraglottic airway device designed for fibreoptic bronchoscopy (FOB)-guided tracheal intubation.57 patients between 18 months and six years of age were randomized to receive either the Aura-I (N.=29) or (N.=28). Primary endpoint was time intubation. Secondary endpoints number attempts insertion, feasibility FOB-guided intubation, oropharyngeal leak pressure (OLP) grade laryngeal view possible complications.No difference found in insertion...
Zunehmend müssen sich Patienten hohen Alters, insbesondere nach einem Trauma, einer Operation mit Anästhesie unterziehen. Im perioperativen Management dieser ist das frühzeitige interdisziplinäre Vorgehen für gute Langzeitergebnisse ausschlaggebend. Das orthogeriatrische Komanagement, Geriater und Anästhesisten bereits früh einbezieht, kommt dem geriatrischen zugute. Für die anästhesiologische Beurteilung des Krankheitszustandes zur präoperativen Risikostratifizierung sind Patientenalter,...
Martian caves are regarded as one of the most interesting locations in which to search for life on planet. Data obtained during MARS2013 expedition at Hamar Laghdad Ridge Tafilalt region Morocco indicate that even small cavities can display thermal behavior is characteristic caves. For example, temperature a cavity equaled 14°C±0.1°C before sunrise, was higher than ambient air (10°C±0.1°C) and proximate rocks (9°C±0.1°C) same time. Within 30 min after when surrounding corresponded 15°C, this...
Aim Diagnosing low-grade periprosthetic joint infections (PJI) can be very challenging due to low-virulent microorganisms capable of forming biofilm. Clinical signs subtle and may similar those aseptic failure. To minimize morbidity mortality preserve quality life, accurate diagnosis is essential. The aim this study was assess the performance various diagnostic tests in diagnosing PJI. Methods Patients undergoing revision surgery after total hip knee arthroplasty were included retrospective...
Aim Serum parameters continue to be a focus of research in diagnosing periprosthetic joint infections (PJI). Several workgroups have recently proposed serum Albumin-Globulin-Ratio (AGR) as potential new biomarker. Due controversies the literature, its usability clinical practice remains uncertain. The aim this study was assess value AGR PJI preoperatively, especially comparison with well-established marker C-reactive Protein (CRP). Method From January 2015 June 2022, patients indicated...