A5069112087- Corporate Management and Leadership
- Prostate Cancer Treatment and Research
- Psychology, Coaching, and Therapy
- Prostate Cancer Diagnosis and Treatment
- Corporate Governance and Management
- Digital Innovation in Industries
- Bladder and Urothelial Cancer Treatments
- Alzheimer's disease research and treatments
- Urologic and reproductive health conditions
- Innovation, Technology, and Society
- Hormonal and reproductive studies
- Sociology and Education Studies
- Cancer, Lipids, and Metabolism
- Blood Coagulation and Thrombosis Mechanisms
- Creativity in Education and Neuroscience
- Corporate Governance and Law
- Estrogen and related hormone effects
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Social and Demographic Issues in Germany
- Team Dynamics and Performance
- Design Education and Practice
- Public Administration and Political Analysis
- Law and Political Science
- Real estate and construction management
- Radiomics and Machine Learning in Medical Imaging
Innsbruck Medical University
2013-2024
Universität Innsbruck
1994-2024
Institut für Unternehmenskybernetik
2015-2022
Bayer (Germany)
2022
Springer Nature (Germany)
2004-2022
München Klinik
2012-2020
University of Applied Management
2014
German Cancer Research Center
2012
National Center for Tumor Diseases
2012
Heidelberg University
2012
The appearance of inflammatory markers associated with amyloid plaques indicates a state chronic inflammation in Alzheimer's disease (AD). Multiple epidemiological studies also suggest that patients taking anti-inflammatory drugs have decreased risk developing AD. Here we present evidence cytokines can alter the metabolism β-am-yloid precursor protein (βAPP). We show combination tumor necrosis factor α and interferon γ triggers production β-amyloid peptides inhibits secretion soluble APPs by...
To investigate, using transrectal colour Doppler ultrasonography, (TRCDUS) whether perfusion of the bladder and prostate is reduced in elderly patients with lower urinary tract symptoms (LUTS), common later life, as experimental data suggest that chronic ischaemia has a key role development LUTS.In 32 LUTS (12 women, mean age 82.3 years, group 1; 20 men, 79.4 2) neck (in women) men) was measured TRCDUS resistive index (RI) pixel density (CPD) determined, assessed by TRUS unit special...
To report on the oncological outcome of organ-sparing surgery (OSS) compared to (total or partial) penectomy regarding recurrence patterns and survival in squamous cell carcinoma (SCC) penis.This was a retrospective study all patients with penile SCC eligible follow-up data at least 2 years our institution. Patients tumors staged ≥ pT1G2 underwent invasive lymph node (LN) staging by dynamic sentinel-node biopsy modified inguinal lymphadenectomy. Radical lymphadenectomy performed when LNs...
Abstract Background Despite recent progress in the identification of genetic and molecular alterations prostate cancer, markers associated with tumor progression are scarce. Therefore precise diagnosis patients prognosis disease remain difficult. This study investigated novel discriminating between low highly aggressive types cancer. Results Using 52 microdissected cell populations low- high-risk tumors, we identified via global cDNA microarrays analysis almost 1200 genes being...
The TMPRSS2-ERG gene fusion resulting in ERG overexpression has been found around 50% of prostate cancers (PCa) and is a very early event tumorigenesis. Most studies have reported on selected surgical cohorts with inconsistent results. We hypothesized that rearrangements impact tumor development investigated the frequency context clinicopathological characteristics.ERG (ERG+ or ERG-) was determined by immunohistochemistry (IHC) 1039 radical prostatectomy (RP) tumors association PSA, D'Amico...
Abstract Purpose: Dihydrotestosterone (DHT) is an important factor in prostate cancer (PCA) genesis and disease progression. Given PCA's strong genetic component, we evaluated the possibility that variation genes involved DHT metabolism influence PCA risk. Experimental Design: We investigated copy number variants (CNV) single nucleotide polymorphisms (SNP). explored associations between CNV of uridine diphospho-glucuronosyltransferase (UGT) from 2B subclass, given their specificity and/or...
Abstract Objectives Selecting patients suspected of having prostate cancer (PCa) for a biopsy remains challenge. Prostate‐specific antigen (PSA)‐based testing is hampered by its low specificity that often leads to negative results or detection clinically insignificant cancers, especially in the 2‐10 ng/mL range. The objective was evaluate novel diagnostic test called Proclarix incorporating thrombospondin‐1 and cathepsin D alongside total free PSA as well age predicting significant PCa....
Background Active surveillance (AS) is increasingly offered to patients with low risk prostate cancer. The present study was conducted evaluate the of tumor under-grading and -staging for AS eligibility. Moreover, we analyzed possible biomarkers predicting more unfavorable final histology. Methods 197 who underwent radical prostatectomy (RPE) but would have met EAU (European Association Urology) criteria (PSA<10 ng/ml, biopsy GS ≤6, ≤2 cancer-positive cores ≤50% in any core clinical stage...
INTRODUCTION AND OBJECTIVES Eotaxin-1 (CCL11) is a protein expressed in various tissues influencing immunoregulatory processes by acting as selective eosinophil chemo-attractant. In prostate cancer (PCa), the expression and functional role of CCL11 have not been intensively investigated so far. Therefore, aim present study was to investigate diagnostic or prognostic potential PCa patients. MATERIALS METHODS We analyzed serum from 140 patients who undergone biopsy due elevated...
The γ‐interferon‐induced enzymes indoleamine 2,3‐dioxygenase and GTP ‐cyclohydrolase are key players in tumor immune escape mechanisms. We quantified serum levels of neopterin tryptophan breakdown (tryptophan, kynurenine, kynurenine‐to‐tryptophan ratio) addition to prostate‐specific antigen ( PSA ) newly diagnosed prostate cancer PC a) patients n = 100) before radical prostatectomy RP as well at time biochemical recurrence BCR after 50) comparison healthy men 49). Effects biomarkers on the...
Study Type – Diagnosis (exploratory cohort) Level of Evidence 2b OBJECTIVE To correlate a subjective blood‐flow rating scale from contrast‐enhanced colour Doppler (CECD) transrectal ultrasonography‐targeted prostate biopsy with the histopathological outcome biopsy. PATIENTS AND METHODS In all, 760 men serum total prostate‐specific antigen (PSA) level ≥1.25 ng/mL and free‐to‐total PSA ratio <18% were included. CECD‐targeted biopsies five cores taken only in hypervascular areas peripheral...
To compare outcomes of patients with asynchronous tumours detected before and after the introduction scrotal ultrasonography (SUS) during routine follow-up examinations.Since January 2001 SUS was also used testicular cancer. A series 16 consecutive bilateral diagnosed while still complying follow up investigations were identified divided into two groups; group by palpation only, 2001, B 2000. The groups compared statistically for interval between tumours, clinical stage, tumour diameter at...
We investigated the role of diabetes mellitus (DM) and molecular mechanisms antidiabetic drugs in prostate cancer (PCa).167 patients with both DM PCa underwent radical prostatectomy (RPE). divided our patient collective into "metformin" users, "insulin" "other drug" users those "no drug/diet only" (control group) analyzed differences aggressiveness laboratory parameters among treatment groups. In addition, we generated a tissue-micro-array (TMA) from RPE specimens for analysis candidate...