A5062630573- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Memory and Neural Mechanisms
- Receptor Mechanisms and Signaling
- Sleep and Wakefulness Research
- Neurological disorders and treatments
- Stress Responses and Cortisol
- Lipid Membrane Structure and Behavior
- Neuropeptides and Animal Physiology
- Neurogenesis and neuroplasticity mechanisms
- Animal testing and alternatives
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Regulation of Appetite and Obesity
- Immunotoxicology and immune responses
- Enzyme Catalysis and Immobilization
- Bat Biology and Ecology Studies
- Retinal Development and Disorders
- Mitochondrial Function and Pathology
- Ion channel regulation and function
- Biotin and Related Studies
- bioluminescence and chemiluminescence research
- Neural dynamics and brain function
- Attention Deficit Hyperactivity Disorder
- Anesthesia and Neurotoxicity Research
The University of Sydney
2024
Washington State University
1991-2009
Yale University
1992
University of Kansas Medical Center
1984-1990
University of Kansas
1984-1987
The University of Texas Health Science Center at Houston
1987
United States Army
1984
University of Wisconsin–Madison
1979
University of California, Irvine
1974
Most synapses in the central nervous system exhibit a prominent electron-opaque specialization of postsynaptic plasma membrane called density (PSD). We have developed procedure for isolation PSDs which is based on their buoyant and insolubility N-lauroyl sarcosinate. Treatment synaptic membranes with this detergent solubilizes most detaches from so that they can be purified gradient. Isolated appear structurally intact those properties characterize them tissue. The isolated are size, shape,...
A dopaminergic projection from the ventral tegmental area to pallidum was identified in rat using anterograde tract tracing and combined retrograde tracing-immunocytochemistry. The found be topographically organized such that fibers innervating ventromedial arose neurons located along midline nuclei of mesencephalon, including nucleus interfascicularis linearis caudalis. Ventral situated more laterally, parabrachialis pigmentosus paranigralis, projected dorsolateral pallidum. substantia...
An analysis was made of the protein composition a fraction postsynaptic densities (PSDs) prepared from rat brain. Protein makes up 90% material in PSD fraction. Two major polypeptide fractions are present, based on sodium dodecyl sulfate polyacrylamide gel electrophoresis. The has molecular weight 53,000, about 45% protein, and comigrates gels with synaptic plasma membrane. other band 97,000, accounts for 17% is not prominent constituent fractions. Six polypeptides higher (100,000-180,000)...
Neurochemical and psychopharmacological studies of rats were designed to examine four hypotheses which have been proposed account for the development behavioral tolerance anticholinesterase, diisopropyl fluorophosphate (DFP). The fact that activity enzymes, adenosine triphosphatase, alkaline phosphatase cytochrome oxidase, did not change concomitantly with measures during chronic treatment DFP suggests nonspecific metabolic changes are unlikely mechanisms tolerance. Similarly, a lack in...
Abstract Isolated REM sleep behavior (iRBD) is a male predominant parasomnia characterized by abnormal dream-enacting movements in sleep. It the prodromal manifestation most strongly associated with development of synucleinopathies, such as Parkinson’s disease or dementia Lewy bodies. While individuals iRBD exhibit significant cortical atrophy shaped distinct gene expression, sex-specific differences structural brain changes remain unknown. In this study, we investigate effect sex on and...
This study was designed to evaluate the role of circuit containing nucleus accumbens, ventral pallidum (VP) and tegmental area (VTA) in motor stimulation produced by microinjection dopamine, alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) or [D-Ala2, MePhe4,Gly-ol5]enkephalin (DAMGO) into VP shell core compartments accumbens. Initial dose-response curves revealed that dopamine approximately equipotent at producing activity after shell, AMPA more effective core, whereas DAMGO...
[3H]Quinuclidinyl benzilate binding to rat brain muscarinic receptors decreased after repeated exposure soman, a potent organophosphorus cholinesterase inhibitor. The topographical distribution of this decrement was analyzed by quantitative receptor autoradiography. After 4 weeks three times week, quinuclidinyl 67 80% control in frontal and parietal cortex, caudate-putamen, lateral septum, hippocampal body, dentate gyrus, superior colliculus, nucleus the fifth nerve, central grey. Minor or...
Uptake of 3H-serotonin is localized to the outer plexiform layer in Long-Evans rat retinas. Autoradiographic accumulation seen only after vitro incubation light, with retinas isolated from underlying sclera. Potassium stimulates release 3H-serotonin. In this species, amacrine cells do not accumulate these compounds; thus appears be site uptake and indoleamine. The age-related loss retinal dystrophic rats coincides temporally spontaneous degeneration photoreceptor that occurs species....
Acid Precursor-L-[3,4-"H]Valine was selected as the radioactive precursor since both subunits of (Na,K)-
Abstract Background Synucleinopathies manifest as a spectrum of disorders that vary in features and severity, including idiopathic/isolated REM sleep behaviour disorder (iRBD) dementia with Lewy bodies. Patterns brain atrophy iRBD are already reminiscent what is later seen overt disease related to cognitive impairment, being associated the development However, how begins progresses remains unclear. Methods A multicentric cohort 1,134 participants, 538 patients synucleinopathies (451...