A5100368430- interferon and immune responses
- RNA modifications and cancer
- Inflammasome and immune disorders
- RNA regulation and disease
- Systemic Lupus Erythematosus Research
- Cytokine Signaling Pathways and Interactions
- Antimicrobial Peptides and Activities
- Bacterial Genetics and Biotechnology
- Birth, Development, and Health
- Advanced Photocatalysis Techniques
- Probiotics and Fermented Foods
- Mosquito-borne diseases and control
- Vitamin C and Antioxidants Research
- Antioxidant Activity and Oxidative Stress
- Diabetes and associated disorders
- Chalcogenide Semiconductor Thin Films
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Ubiquitin and proteasome pathways
- Insect Utilization and Effects
- Animal Disease Management and Epidemiology
- Retinoids in leukemia and cellular processes
- Gut microbiota and health
- Diet and metabolism studies
- Nuclear Receptors and Signaling
- Immune Cell Function and Interaction
National Center of Biomedical Analysis
2021-2024
China Agricultural University
2024
Northeast Agricultural University
2022-2024
Jilin Agricultural University
2018
Sichuan University
2007
Atrazine (ATR) is a widely used herbicide worldwide that can cause kidney damage in humans and animals by accumulation water soil. Lycopene (LYC), carotenoid with numerous biological activities, plays an important role protection due to its potent antioxidant anti-inflammatory effects. The current study sought investigate the of interactions between mtDNA cGAS-STING signaling pathway LYC mitigating PANoptosis inflammation kidneys induced ATR exposure. In our research, 350 mice were orally...
Di(2-ethylhexyl) phthalate (DEHP) is a highly harmful and persistent environmental pollutant. Due to its unique chemical composition, it frequently dissolves enters the environment endanger human animal health. Lycopene natural bioactive component that can potentially reduce risk of factor-induced chronic diseases. The present study sought explore role underlying mechanism lycopene (LYC) on DEHP-induced renal inflammatory response apoptosis. In this study, mice were orally treated with LYC...
Antibiotic residues can cause antibiotic resistance in livestock and their food safety-related issues have increased the consumer demand for products lacking these residues. Hence, developing safe effective alternatives is important to animal feed industry. With strong antibacterial actions, antimicrobial peptides potential as alternatives. We investigated immunomodulatory activities mechanisms of action an peptide. The hybrid peptide magainin II-cecropin B (Mag II-CB) gene was transformed...
Abstract Background Type 1 diabetes is believed to be an autoimmune condition, characterized by destruction of insulin-producing cells, due the detrimental inflammation in pancreas. Growing evidences have indicated important role type I interferon development diabetes. Methods Trex1 -deficient rats were generated using CRISPR-Cas9. The fasting blood glucose level rat was measured a Roche Accuchek monitor. levels insulin, islet autoantibodies, and interferon-β enzyme-linked immunosorbent...
Cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is critical for cytosolic DNA-sensing and the subsequent immune responses. The inappropriate activation this leads to DNA-induced autoimmune response. Understanding precise regulation cGAS-STING important developing therapeutics treat several diseases caused by self-DNA.We report that Meloxicam (MXC) inhibits intracellular DNA-, but not RNA-induced We find MXC phosphorylation STING examining in different cells with...
Abstract The recognition of cytosolic nucleic acid triggers the DNA/RNA sensor–IRF3 axis-mediated production type I interferons (IFNs), which are essential for antiviral immune responses. However, inappropriate activation these signaling pathways is implicated in autoimmune conditions. Here, we report that indomethacin, a widely used nonsteroidal anti-inflammatory drug, inhibits acid-triggered IFN production. We found both DNA- and RNA-stimulated expression can be effectively blocked by...