A5072527322- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- RNA and protein synthesis mechanisms
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- RNA Research and Splicing
- Mycobacterium research and diagnosis
- Immune cells in cancer
University of Newcastle Australia
2019-2025
Wannan Medical College
2023
Abstract Background: While MYCN-amplified neuroblastoma has been the focus of research in past three decades, most human neuroblastomas do not harbour MYCN oncogene amplification, and their tumorigenic factors are unknown. Long non-coding RNAs (lncRNAs) regulate tumorigenesis by modulating expression molecular targets, however, there is limited literature on therapeutic targeting lncRNAs with small molecule compounds. Aims: To determine oncogenic mechanism though which lncRNA lncNB promotes...
Abstract The use of mitochondrial inhibitors to target oxidative phosphorylation (OXPHOS) in cancer treatment presents a challenge due dose-limiting toxicities. Moreover, while glycolysis-deficient cancers are vulnerable OXPHOS inhibition preclinical models, the full extent phenotypical and mechanistic consequences inhibiting capable glycolysis is not yet well understood. Our results presented here offer promising insights into potential therapeutic gains from combining p53 restoration...
Abstract The involvement of noncoding RNAs (ncRNAs) in cancer pathogenesis has been increasingly appreciated. Although the expression and function ncRNAs is highly tissue type- context-dependent, we have found that long ncRNA (lncRNA) MILIP (Myc-inducible lncRNA inactivating p53) commonly upregulated TCGA samples across 20 types its high was associated with poor overall survival patients. increase subsequently corroborated using situ hybridization (ISH) a panel colorectal cohort non-small...
Abstract Genomic amplification of the distal portion chromosome 3q, which encodes a number oncogenic proteins, is one most frequent chromosomal abnormalities in malignancy. Here we functionally characterise non-protein product 3q region, long noncoding RNA (lncRNA) PLANE, upregulated diverse cancer types through copy gain as well E2F1-mediated transcriptional activation. PLANE forms an RNA-RNA duplex with nuclear receptor co-repressor 2 (NCOR2) pre-mRNA at intron 45, binds to heterogeneous...
Abstract Cancer metabolism is highly heterogenous and flexible with the Warburg effect or oxidative phosphorylation (OXPHOS) prevailing in a cancer type- context-dependent manner. Past studies have demonstrated that targeting OXPHOS robustly inhibits glycolysis-deficient cell viability tumorigenicity. However, therapeutic potential of inhibition metabolically glycolysis-competent cancers unclear. Furthermore, whether depletion OXPHOS-derived ATP abolition OXPHOS-supported biosynthesis major...