A5031509425- Chemical Synthesis and Analysis
- Complementary and Alternative Medicine Studies
- Antimicrobial Resistance in Staphylococcus
- RNA and protein synthesis mechanisms
- Mass Spectrometry Techniques and Applications
- Medicinal Plant Extracts Effects
- Blood Coagulation and Thrombosis Mechanisms
- Venomous Animal Envenomation and Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Risk and Safety Analysis
- Antibiotic Resistance in Bacteria
- Hormonal and reproductive studies
- Forensic Toxicology and Drug Analysis
- Chemical synthesis and alkaloids
- Heavy Metals in Plants
- Synthesis and Reactions of Organic Compounds
- Metabolomics and Mass Spectrometry Studies
- Analytical Chemistry and Chromatography
- Protein Structure and Dynamics
- Carbohydrate Chemistry and Synthesis
- Glycosylation and Glycoproteins Research
- Advanced Proteomics Techniques and Applications
- Chemical Safety and Risk Management
- Scientific Measurement and Uncertainty Evaluation
- Psychedelics and Drug Studies
Mayo Clinic
1992-1997
WinnMed
1997
University of Minnesota
1993
Stable isotopically labeled (SIL) tryptic peptides, cleavable SIL and a full-length protein were compared for internal calibration (i.e., as calibrators) external standards) when quantifying three forms of unlabeled, human thyroglobulin (Tg) by bottom-up analysis. All materials proteins standardized amino acid analysis to ensure traceability measurements allow confident assignment accuracy. The Tg quantified (1) the primary reference material BCR457-a native purified from thyroids, (2)...
Buried water molecules in the structurally homologous family of eukaryotic serine proteases were examined to determine whether buried waters and their protein environments are conserved these proteins. We found 16 equivalent sites trypsin/ogen, chymotrypsin/ogen, elastase, kallikrein, thrombin, rat tonin mast cell protease, 5 additional enzymes which share primary specificity trypsin. Based on an alignment 30 protease sequences, it appears that 21 highly conserved. The comprised primarily...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and dopamine receptor modulating activity of lactam conformationally constrained analogs Pro-Leu-Gly-NH2Uma Sreenivasan, Ram K. Mishra, Rodney L. JohnsonCite this: J. Med. Chem. 1993, 36, 2, 256–263Publication Date (Print):January 1, 1993Publication History Published online1 May 2002Published inissue 1 January 1993https://pubs.acs.org/doi/10.1021/jm00054a010https://doi.org/10.1021/jm00054a010research-articleACS PublicationsRequest reuse...
Certified solution standards are widely used in forensic toxicological, clinical/diagnostic, and environmental testing. Typically, these purchased as ampouled solutions with a certified concentration. Vendors present concentration uncertainty differently on their Certificates of Analysis. Understanding the factors that impact which have been considered vendor's assignment critical to understanding accuracy standard testing results. variables is also important for laboratories seeking comply...
Dietary supplements derived from botanicals are commonly consumed and investigated in biomedical studies for their potential health benefits. Accurate identification quantification of key chemical constituents botanical ingredients is necessary consistent product preparations reproducible research results. Manufacturers need quantitative reference materials the interest to verify content products. The rigor reproducibility enhanced through thorough characterization interventions used...
The antimicrobial activity of vancomycin and related glycopeptide antibiotics is due to stereospecific recognition polypeptide components in bacterial cell walls. To better understand how these recognize determinants, we have developed dynamic models the complexes formed by aglycon two different dipeptide ligands, Ac-D-ala-D-ala Ac-D-ala-gly. Molecular dynamics simulations complexes, initially conditioned with distance constraints derived from two-dimensional nuclear magnetic resonance (NMR)...
The antimicrobial activity of vancomycin and related glycopeptide antibiotics is due to stereospecific recognition polypeptide components in bacterial cell walls. To better understand how these recognize determinants, we have developed dynamic models the complexes formed by aglycon two different dipeptide ligands, Ac-D-ala-D-ala Ac-D-ala-gly. Molecular dynamics simulations complexes, initially conditioned with distance constraints derived from two-dimensional nuclear magnetic resonance (NMR)...