A5051969760- Head and Neck Cancer Studies
- Cancer-related molecular mechanisms research
- Vestibular and auditory disorders
- Pharmacovigilance and Adverse Drug Reactions
- Hearing Loss and Rehabilitation
- Drug-Induced Adverse Reactions
- Climate Change and Health Impacts
- Epigenetics and DNA Methylation
- Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Obstructive Sleep Apnea Research
- Esophageal Cancer Research and Treatment
- Air Quality and Health Impacts
- Cancer Genomics and Diagnostics
- Hippo pathway signaling and YAP/TAZ
- Pancreatic and Hepatic Oncology Research
- Cancer-related gene regulation
- Pharmaceutical studies and practices
- Voice and Speech Disorders
- Lung Cancer Treatments and Mutations
- Insect Resistance and Genetics
- Air Quality Monitoring and Forecasting
- Cleft Lip and Palate Research
- Circular RNAs in diseases
- Hearing, Cochlea, Tinnitus, Genetics
Xiamen University
2020-2025
Zhongshan Hospital of Xiamen University
2022-2024
Fujian Medical University
2020-2022
First Affiliated Hospital of Xiamen University
2021
Famotidine is an H2 receptor antagonist and currently used on a large scale in gastroenterology. However, may also cause severe toxicity to organ systems, including the blood system, digestive urinary system. The objective of this study was scientifically systematically investigate adverse events (AEs) real world through FDA Adverse Event Reporting System (FAERS) database. A disproportionality analysis quantify signals AEs associated with FAERS data from first quarter 2004 2023. clinical...
Abstract Background Pancreatic cancer is one of the most malignant abdominal tumors. DDX60 has been shown to be associated with a variety tumor biological processes. However, in pancreatic not reported. Our study confirmed that can serve as novel biomarker for diagnosis and treatment cancer. Materials methods We downloaded datasets from GEO TCGA databases, respectively. To investigate relationship between expression prognosis GSEA analysis was performed on DDX60. RNA-seq further explore...
Traditionally, the AJCC TNM staging system has been primary tool for assessing severity and prognosis of laryngeal cancer. Although several studies have demonstrated that log odds positive lymph nodes (LODDS) offers superior predictive accuracy compared to other cancers, there is limited research This study analyzed data from SEER database (2000-2019). Independent risk factors survival were identified using univariate multivariate Cox regression analyses, different prognostic models...
Abstract Background Cisplatin is a commonly used chemotherapeutic drug in clinics, and long‐term application will lead to hearing impairment. LLY‐283, an inhibitor of PRMT5, has not been reported deafness. Our study aimed explore the mechanism LLY‐283 Materials Methods First, we performed RNA‐seq (cisplatin experimental group DMSO control group) obtain biological processes mainly involved differentially expressed genes (DEGs). CCK‐8 LDH experiments were observe effect on cisplatin‐induced...
The incidence of oropharyngeal squamous cell carcinomas (OPSCC) has increased in recent decades, and human papillomavirus (HPV) infection is the main cause OPSCC. data regarding causes death (CODs) are vitally important informing follow-up strategies revising treatment to deal with any possible preventable treatment-related COD. However, limited studies have assessed competing COD by HPV status patients OPSCC.We aimed analyze distribution according retrospectively included stage I-IVB OPSCC...
Airborne fine particulate matter with an aerodynamic diameter equal to or smaller than 2.5 μm (abbreviated as PM2.5) increases the risk of nasal lesions, but underlying molecular mechanism has not been fully elucidated. In atmosphere, composition PM2.5 collected varies in physical and chemical properties, which affects its damage human health. Thus, we constructed artificial particles based on actual investigated vivo effects exposure oxidative stress, inflammatory response, mucosa...
Depending on the source of blastophore, there are various subtypes laryngeal cancer, each with a unique metastatic risk and prognosis. The forecasting their prognosis is pressing issue that needs to be resolved. This study comprised 5953 patients glottic carcinoma 4465 individuals non-glottic type (supraglottic subglottic). Five clinicopathological characteristics were screened using univariate multivariate regression for CoxPH (Cox proportional hazards); other models, 10 (glottic) 11...
The primary objective of this study was to closely monitor and identify adverse events (AEs) associated with Sorafenib, a pharmacological therapeutic agent used treat hepatocellular carcinoma, renal cell thyroid cancer. ultimate goal optimize patient safety provide evidence-based guidance for the appropriate use drug.
Objective:To explore the relationship between benign paroxysmal positional vertigo （BPPV） and sleep disorders through analysis of subjective objective conditions. Methods:Forty-five patients with BPPV fifty controls who met inclusion exclusion criteria were selected for Pittsburgh quality index （PSQI） questionnaire survey polysomnography （PSG） check, SPSS 23.0 was used to compare analyze results. Results:Compared control group, had changes in structure, high apnea hypopnea （AHI）...
Abstract Background： Otosclerosis is a primary bone disease caused by the labyrinth, resorption, and abnormal deposition. According to current research, it complex related genetic environmental factors. However, molecular mechanism associated with otosclerosis has not been clearly revealed. Methods： The purpose of this study was screen differentially expressed genes (DEGs) in patients corresponding normal controls RNA sequencing (RNA-Seq) then deal DEGS weighted gene co-expression network...
<sec> <title>BACKGROUND</title> The incidence of oropharyngeal squamous cell carcinomas (OPSCC) has increased in recent decades, and human papillomavirus (HPV) infection is the main cause OPSCC. data regarding causes death (CODs) are vitally important informing follow-up strategies revising treatment to deal with any possible preventable treatment-related COD. However, limited studies have assessed competing COD by HPV status patients </sec> <title>OBJECTIVE</title> We aimed analyze...
Abstract Background Hearing loss (HL) is a public health event, which seriously affects the happiness of people’s life. Hsa-miR-124-5p has not been reported in HL. This study aimed to construct miRNA-mRNA network associated with Methods Subjects were screened through clinical audiology experiments. MiRNA-seq was performed on peripheral blood mononuclear cells (PBMC), and differentially expressed miRNAs (DEMs, P -Value < 0.05, ∣log FC | ≥1) obtained by analysis. We selected most...