A5107707559- Cancer Cells and Metastasis
- Erythrocyte Function and Pathophysiology
- Cellular Mechanics and Interactions
- Hippo pathway signaling and YAP/TAZ
University of Calgary
2024
Stem cells perceive and respond to biochemical physical signals maintain homeostasis. Yet, it remains unclear how stem sense mechanical from their niche in vivo. In this work, we investigated the roles of PIEZO mechanosensitive channels intestinal cell (ISC) niche. We used mouse genetics single-cell RNA sequencing analysis assess requirement for ISC maintenance. vivo measurement basement membrane stiffness showed that ISCs reside a more rigid microenvironment at bottom crypt....
ABSTRACT Stem cells continuously perceive and respond to various environmental signals maintain homeostasis. In addition biochemical factors, the stem cell niche is subjected mechanical physical cues. However, it remains unclear how can sense from their in vivo . Since intestinal constantly directly face external environment, we investigated roles of mechano-sensing PIEZO ion channels gut niche. By employing mouse genetics performing single-cell RNAseq analysis, revealed absolute requirement...