A5008233347- Natural Antidiabetic Agents Studies
- Natural product bioactivities and synthesis
- Phytochemicals and Antioxidant Activities
- Plant biochemistry and biosynthesis
- Synthesis and biological activity
- Genomics, phytochemicals, and oxidative stress
- Cholinesterase and Neurodegenerative Diseases
- Phytochemicals and Medicinal Plants
- Traditional and Medicinal Uses of Annonaceae
- Computational Drug Discovery Methods
- Free Radicals and Antioxidants
- Biological Activity of Diterpenoids and Biflavonoids
University of Ngaoundéré
2021-2025
Alzheimer’s disease (AD) and diabetes are non-communicable diseases with global impacts. Inhibitors of acetylcholinesterase (AChE) butyrylcholinesterase (BChE) suitable therapies for AD, while α-amylase α-glucosidase inhibitors employed as antidiabetic agents. Compounds were isolated from the medicinal plant Terminalia macroptera evaluated their AChE, BChE, α-amylase, inhibitions. From 1H 13C NMR data, compounds identified 3,3′-di-O-methyl ellagic acid (1), 3,3′,4′-tri-O-methyl...
Diabetes mellitus is a metabolic disorder which one of the leading causes mortality and morbidities in elderly humans. Chronic diabetes can lead to kidney failure, blindness, limb amputation, heart attack stroke. Physical activity, healthy diets medications reduce incidence diabetes, so search for more efficient antidiabetic therapies, most especially from natural products, necessity. Herein, extract roots medicinal plant Pterocarpus erinaceus was purified by column chromatography afforded...
Alzheimer's disease (AD) is a non-communicable with global impact. Inhibitors of acetylcholinesterase (AChE) are suitable therapies for AD. In this work, we report the isolation antiacetylcholinesterase compounds from methylene chloride (DCM) extract medical fungus Ganoderma applanatum (Pers.) Pat (Ganodermataceae). Chemical evaluation using chromatographic technics led to (1:1) mixture ergosterol (1) and stellasterol (2), palmitic acid (3), ganodermanondiol (4), lucidumol B (5) lupeol (6)....
The current study was conducted to isolate the phytoconstituents from Erythrina senegalensis leaves and stem bark evaluate their inhibitory activity against α-glucosidase, digestive enzyme related diabetes mellitus. Phytochemical investigation of resulted in isolation three saponins (3–5), two triterpenoids (7 8) steroids (10a 10b) as inseparable mixture, while one saponin (6), triterpenoid (9) mixture cinnamates (2a 2b) were isolated bark. Except for compounds 2 b, 7, 8, 10a 10 b all are...
A new abietane-type diterpenoid, rubesanolidic acid (1), alongside six known compounds including β-sitosterol (2), lupeol (3), betulinic (4) ursolic (5), 3-O-β-D-glucopyranoside (6) and stigmasterol (7) were isolated from the roots of Burkea africana through column chromatography. Their structures elucidated spectroscopic analyses (UV, IR, MS, 1D 2D NMR) data by comparison with previous studies. The extract tested for their α-amylase inhibition. was more active than a percentage inhibition...
Cancers account for many deaths worldwide and natural compounds their derivatives are interesting chemotherapeutic agents cancer drug development. In this study, a compound 3,3'4-trimethoxy-4'-rutinosylellagic acid (TR2) its acetylated derivative 3,3'4-trimethoxy-4'-hexaacetylrutinosylellagic (TR22) were evaluated antioxidant anticancer effects against estrogen sensitive (MCF-7) non-sensitive (MDA-MB 231) breast adenocarcinoma. the β-Carotene-linoleic assay, DPPH