Propolis is very popular for its beneficial health properties, such as antimicrobial activity and antioxidant effects. It one of the most long-serving traditional medicines to mankind due interesting chemical diversity therapeutic properties. The detailed information propolis samples necessary guarantee safety it be accepted into care systems. phenolic profile hydroethanolic extract was determined using HPLC-DAD, evaluated five complementary methods. Triterpenoids were isolated column...

Alzheimer’s disease (AD) and diabetes are non-communicable diseases with global impacts. Inhibitors of acetylcholinesterase (AChE) butyrylcholinesterase (BChE) suitable therapies for AD, while α-amylase α-glucosidase inhibitors employed as antidiabetic agents. Compounds were isolated from the medicinal plant Terminalia macroptera evaluated their AChE, BChE, α-amylase, inhibitions. From 1H 13C NMR data, compounds identified 3,3′-di-O-methyl ellagic acid (1), 3,3′,4′-tri-O-methyl...

Context: Nauclea latifolia Smith (Rubiaceae) is a small tree found in tropical areas Africa. It used traditional medicine to treat malaria, epilepsy, anxiety, pain, fever, etc.

Hyperlipidemia and oxidative stress are major risk factors for atherosclerosis, all three among the most important cardiovascular diseases. Cassia occidentalis aqueous extract has been used in African traditional medicine treatment of hypertension associated This study was undertaken to evaluate hypolipidemic anti-atherosclerotic properties leaves C. rats with hypercholesterolemia (HC). Sixty Normocholesterolemic (NC) male were divided into six groups (n = 10) fed a high-cholesterol (HC)...

The extracts of some propolis samples were analysed by GC-MS and then purified column chromatography. latter led to the isolation a new mono-ether glycerol, 1'-O-eicosanyl glycerol triterpene, methyl-3β,27-dihydroxycycloart-24-en-26-oate together with known triterpenoids namely betulin, 3β-hydroxylanostan-9,24-dien-21-oic acid, mangiferonic mixture ambolic acid β-sitosterol, 3β-hydroxycycloartan-12,24(25)-diene 27-hydroxymangiferonic acid. DPPH radical scavenging potential compounds...

Diabetes as well the enhanced microbial multidrug resistance resulting from biofilm formation, constitutes some of major health problems around world. Triterpenoids and their derivatives have been shown to a great contribution in this domain. A small library benzoyl esters lupeol β-amyrin was synthesized structures were characterized by electronic ionization mass spectrometry (EIMS). Their inhibitory potential on pathogenic bacteria biofilms, action α-amylase β-glucosidase activities...

Diabetes mellitus is a metabolic disorder which one of the leading causes mortality and morbidities in elderly humans. Chronic diabetes can lead to kidney failure, blindness, limb amputation, heart attack stroke. Physical activity, healthy diets medications reduce incidence diabetes, so search for more efficient antidiabetic therapies, most especially from natural products, necessity. Herein, extract roots medicinal plant Pterocarpus erinaceus was purified by column chromatography afforded...

A previously unpublished xanthone named securidacaxanthone D (1) and five known analogues: 1,7-dihydroxyxanthone (2), 7-hydroxy-1,2-dimethoxy-xanthone (3), 1,5-dihydroxy-6,7-dimethoxyxanthone (4), 1,7-dihydroxy-3-methoxyxanthone (5), 1,7-dihydroxy-4-methxyxanthone (6) were isolated from the ethyl acetate soluble fraction obtained liquid-liquid partition of crude hydro-ethanolic extract roots Securidaca longipedunculata. Their structures determined by analysis 1D -(1H 13C), 2D-(COSY, HSQC...

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Five extracts of propolis Adamawa Cameroon were obtained by percolation and maceration with five different solvents: hexane, ethyl acetate, ethanol, methanol water, in order increasing polarity. Phytochemical screening was carried out on the total content flavonoids polyphenols evaluated photometric methods. The flavonoid using Neu reagent (2-aminodiethyl diphenylborinate) quercetin as standard results varied from 0.84±0.02 gQE/100gRM acetate extract to 1.52±0.06 ethanol extract. polyphenol...

Propolis is rich in diverse bioactive compounds. samples were collected from three localities of Cameroon and used the study. Column chromatography separation propolis MeOH:DCM (50:50) extracts yielded a new isoflavonol, 2-hydroxy-8-prenylbiochanin A (1) alongside 2',3'-dihydroxypropyltetraeicosanoate (2) triacontyl p-coumarate (3) isolated for first time together with seven compounds: β-amyrine (4), oleanolic acid (5), acetate (6), lupeol (7), betulinic (8), (9) lupenone (10). These...

Inflammatory diseases are a real public health problem worldwide. Many synthetic drugs used in the treatment of inflammatory such as steroidal anti-inflammatory drugs, nonsteroidal (NSAIDs) and immunosuppressive have harmful side effects. However, there natural products like propolis, which is traditionally pain. The objective this work was to evaluate analgesic activities ethyl ester arachic acid, compound isolated from Cameroonian propolis. acid by chromatography ethanolic extract propolis...

Graptophyllum pictum is a tropical plant noticeable for its variegated leaves and exploited various medicinal purposes. In this study, seven compounds, including three furanolabdane diterpenoids, i.e., Hypopurin E, A B, as well with Lupeol, β-sitosterol 3-O-β-d-glucopyranoside, stigmasterol 3-O-β-d-glucopyranoside mixture of stigmasterol, were isolated from G. pictum, their structures deduced ESI-TOF-MS, HR-ESI-TOF-MS, 1D 2D NMR experiments. The compounds evaluated anticholinesterase...

Cissus quadrangularis Linn grows in Savannah areas Africa (Cameroon, Mali, Mauritania, Senegal, etc). In traditional medicine, the plant is used to treat anorexia, asthma, sickle cells, colds, pains, malaria, asthma and as an analgesic. vivo animal models of epilepsy (maximal electroshock, nmethyl -d-aspartate, pentylenetetrazol, isonicotinic hydrazid acid strychnine -induced convulsions or turning behavior) insomnia (diazepam sleep) were used. The aqueous extract stems C. strongly increased...

Three extracts of propolis harvested from Nkambe, North-West region Cameroon were characterized by GC-MS analysis and their gastric cytoprotective, antisecretory antioxidant properties evaluated using experimentally-induced ulcers in rats.The rich phytoconstituents occurring as sugars, triterpenes a mixture (fatty acids+triterpenes+alkenyl resorcinols) the methanol, hexane acetone extracts, respectively with Mangifera indica major plant source.Three triterpenes, lupeol, lupenone,...

An aliphatic alkene namely pentapentacontene (4) was isolated for the first time from a natural source, Gardenia aqualla, along with fourteen other compounds including nonacosanol (1), tetratriacontanol (2), octatriacontanol (3), β-sitosterol (5) and stigmasterol (6), daucosanol (7), ursolic acid (8), uvaol (9), 3β,19α,23β,24α-tetrahydroxyurs-12-en-28-oic (10), lupenone (11), oleanolic (12), vanillin (13), vanillic (14) D-mannitol (15). α-glucosidase inhibitory assay revealed that MeOH EtOAc...

The Nile tilapia is a widely consumed fish, its scales dumped in nature as waste have been recovered the formulation of antiseptic creams because high content chitin, precursor chitosan. Creams advantage being more comfortable on skin and allow prolonged administration active ingredient. Chitosan obtained with yield 21.2%. FTIR analysis chitosan showed numerous bands phase groups present successful deacetylation assessed intensity at 1650 cm−1 1315 confirm by SEM an abundance Carbone...

The aim of this study was to isolate compounds from Cameroonian propolis extracts and test their antibacterial activities against bacteria isolated carcass at the Yaound� slaughterhouse. n-hexane, ethyl acetate ethanol samples Ngaoundal Tala-Mokolo were separated by successive silica gel column chromatography give six triterpenes. Their structures determined as 25-cyclopropyl-3β-hydroxyurs-12-ene (7), cycloart-3β-hydroxy-12, 25(26)-diene (8), lup-20(29)-en-3-one (9), olean-12-en-3β, 28-diol...