A5100654018- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and biological activity
- Chemical Synthesis and Reactions
- Phenothiazines and Benzothiazines Synthesis and Activities
- Multicomponent Synthesis of Heterocycles
- Veterinary medicine and infectious diseases
- Sulfur-Based Synthesis Techniques
- Asymmetric Synthesis and Catalysis
- Ionic liquids properties and applications
- Crystal structures of chemical compounds
- Oxidative Organic Chemistry Reactions
- Pharmacological Effects of Natural Compounds
- Analytical Chemistry and Chromatography
- Synthesis and Reactivity of Heterocycles
- Bioactive Compounds and Antitumor Agents
- Covalent Organic Framework Applications
- Synthesis of heterocyclic compounds
- Microwave-Assisted Synthesis and Applications
- Catalytic Cross-Coupling Reactions
- Metal-Organic Frameworks: Synthesis and Applications
- Click Chemistry and Applications
- Cholinesterase and Neurodegenerative Diseases
- Garlic and Onion Studies
- Vanadium and Halogenation Chemistry
- Marine Toxins and Detection Methods
Suzhou Traditional Chinese Medicine Hospital
2025
Shijiazhuang University
2013-2023
Hunan Normal University
2023
Hebei Medical University
2022
Huazhong University of Science and Technology
2019
South China University of Technology
2019
Dalian University
2014-2018
Dalian University of Technology
2014-2018
Hebei University of Science and Technology
2014
Lewis pair cooperation provides a facile approach for polymerizing dissymmetric divinyl polar monomers such as 4-vinylbenzyl methacrylate in excellent regioselectivity and high reactivity at mild conditions, affording soluble polymers bearing pendant active vinyl groups with molecular weight (up to 6.4 × 105 g/mol) narrow polydispersity (PDI < 1.5). ESI-TOF MS study demonstrated that the polymerization process only concerned methacrylic double bond selectively remained allylic or styrene C═C bond.
Acute ischemic stroke poses major challenges due to high disability and mortality rates. Ferroptosis, a form of regulated cell death triggered by iron-induced oxidative stress, plays key role in injury. Despite its long history treatment, the mechanism Buyang Huanwu Decoction (BHD) ferroptosis remains unclear. Network pharmacology predicted BHD's active components pathways, while Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry (UPLC-MS/MS) confirmed main ingredients. Middle...
Several pleuromutilin derivatives possessing thiadiazole moieties were synthesized via acylation reactions under mild conditions. The in vitro antibacterial activities of the against methicillin-resistant S. aureus, epidermidis, E. coli, and B. cereus tested by agar dilution method Oxford cup assay. All screened compounds displayed potent activity. Compound 6d was most active agent because its lowest MIC value largest inhibition zone. Docking experiments performed to understand possible mode...
4-Substituted 1,4-dihydropyridine-3,5-dicarboxylates (4) have been synthesized by the solvent-free reaction of aldehyde, methyl propiolate and ammonium carbonate catalyzed ionic liquid 1-carboxymethyl-3-methylimidazolium tetrafluoroborate under ultrasonic irradiation. The effects changes in power, temperature, catalysts reactants on synthesis 4-substituted are discussed. With optimized conditions, various aldehydes were used to synthesize 1,4-dihydropyridines influence ultrasound Compared...
The chemistry of cationic forms clusterfullerenes remain less explored than that the corresponding neutral or anionic species. In present work, M3 N@Ih -C80 (M=Sc Lu) cations were generated by both electrochemical and chemical oxidation methods. as-obtained successfully underwent typical Bingel-Hirsch reaction fails with Sc3 . Two isomeric cation derivatives, [5,6]-open [6,6]-open adducts, synthesized, former has never been prepared means a clusterfullerenes. case Lu3 cation, however, only...
New dual binding site acetylcholinesterase (AChE) inhibitors have been designed and synthesized as a new drug candidate for the treatment of Alzheimer's disease (AD) through to both catalytic peripheral sites enzyme. Therefore, series 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives 6a-j were investigated their ability inhibit activity human AChE (hAChE) in comparison with huperzine-A. All compounds found activity, especially 6c 6i inhibition value 76.10% 77.82%, respectively. The...
The docking study on a series of 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives with acetylcholinesterase has been demonstrated. synthesis and characterization were described. All target compounds evaluated in vitro for the inhibitory activities against AChE via Ellman colorimetric assay. Most possessed anti-acetylcholinesterase activity. preliminary structure-activity relationships discussed. Keywords: Acetylcholinesterase, Inhibitors, Synthesis, Heterocycles, Docking, derivative
An efficient copper‐catalyzed N‐arylation reactions of imidazole, indole, and triazole with aryl or heteroaryl halides using cyclen derivatives as organic base ligand at moderate temperature have been investigated. The cross‐couplings proceed smoothly good to excellent yields.
Lewis pair polymerization is a powerful method for preparing soluble polymers bearing pendant active vinyl groups by directly polymerizing dissymmetric divinyl polar monomers. Herein, we present strategy synthesizing block and brush copolymers via tandem of methacrylates, "thiol-ene" click reaction organocatalytic ring-opening lactide.
An efficient method for the synthesis of N,N-bis(phenacyl)anilines was developed via smooth condensation anilines with α-bromoacetophenones in presence sodium carbonate as acid acceptor and polyethylene glycol 400 (PEG 400) catalyst at room temperature under solvent-free conditions by using 350 W ultrasound irradiation. In addition to experimental simplicity, main advantages procedure are mild conditions, short reaction times (30-45 min), high yields (73-83 %).
Abstract C 15 H 14 ClNO 4 , monoclinic, P2 1 /c (no. 14), a = 8.3515(6) Å, b 7.4351(5) c 23.931(2) β 96.655(1)°, V 1476.0 Å 3 Z 4, R gt (F) 0.0503, wR ref (F 2 ) 0.1412, T 298 K.
Abstract A simple, efficient, and convenient method for the photodimerization of 4-aryl-1,4-dihydropyridine in room-temperature ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate ([Bmim][BF4]) has been developed. By this way, head-to-tail syn-dimers 3,9-diazatetraasteranes were obtained good to excellent yields. In addition, [Bmim][BF4] can be reused at least 5 times as medium without obvious decrease reaction time yield.
E-mail: lixiaoyun06@126.comReceived October 29, 2013, Accepted February 22, 2014The enantioselective α-chlorination of cyclic β-ketoesters catalyzed by chiral 2-aminoalcohol derivatives (2f)has been developed. For the optically active α-chlorinated products, isolated yields are in range 85-94% and enantiomeric excesses up to 84% ee.Key Words : Enantioselective α-chlorination, 2-Aminoalcohol derivatives, β-KetoestersIntroductionThe construction C-X stereogenicityhas gained considerable...
GRAPHICAL ABSTRACTUllmann diaryl ether synthesis catalyzed by copper (I)/pyridine-functionalized silaneAll authorsBaohua Zhang, Lanxiang Shi, Ruixia Guo & Sijie Liuhttps://doi.org/10.1080/10426507.2015.1119135Published online:28 April 2016
Abstract A direct asymmetric aldol reaction of aldehydes and acetone catalyzed by L ‐Pro‐ ‐Trp was performed in β ‐caprolactamquaternary ammonium salt coordination ionic liquid media the presence N ‐methylmorpholine (NMM) high yield with good enantioselectivity. The approach has advantages simple product isolation, reusable catalyst ion liquids.
Ullmann-type diaryl ether synthesis was performed under mild conditions in DMF/K2CO3 using a pyridine-functionalized silane as ligand. The products were obtained good yields. This method toler...
C 33 H 46 ClNO 5 S
Abstract C 64 H 44 Br 4 N 8 O Zn 2 , monoclinic, P 1 / c (No. 14), a = 6.6263(5) Å, b 24.355(2) 18.2418(15) β 96.433(2)°, V 2925.4(4) Å 3 Z 2, R gt ( F ) 0.0400, wR ref 0.1302, T 296(2) K.
Abstract In order to search for high activity acetylcholinesterase (AChE) inhibitors, novel 2 H ‐thiazole[3,2‐ b ][1,2,4]triazine‐3,7‐diones were synthesized by substituted benzaldehyde, bromoacetonitrile and 6‐benzyl‐3‐thio‐3,4‐dihydro‐1,2,4‐triazine‐5(2 )‐one in one pot under the assistance of ultrasound. The synthesis possible reaction mechanism proposed. structures target compounds confirmed 1 NMR, 13 C NMR HRMS. All had inhibitory against AChE, compound...
The authors study an efficient and green approach for the synthesis of 7H-thiazolo [3, 2-b][1,2,4]triazin-7-one derivatives as AChE inhibitors. 7H-thiazolo[3,2-b][1,2,4]triazin-7-ones were designed by molecular docking, readily prepared via a one-pot reaction in morpholine hydrosulfate ([Hnhm]HSO4) lonic liquid catalyst solvent. inhibitory activity was carried out through using Ellman colorimetric assay. had been successfully synthesized catalyst. Most target compounds exhibited more than...
Abstract The optically active α‐chlorinated products are obtained using inexpensive, commercially available NCS as chlorine source.