A5073023677- Trace Elements in Health
- Heavy Metal Exposure and Toxicity
- Parkinson's Disease Mechanisms and Treatments
- Cancer, Hypoxia, and Metabolism
- Iron Metabolism and Disorders
- RNA modifications and cancer
- Immune Cell Function and Interaction
- Nuclear Receptors and Signaling
- Adipose Tissue and Metabolism
- Neuroscience and Neuropharmacology Research
- RNA regulation and disease
- Reproductive Physiology in Livestock
- Signaling Pathways in Disease
- Retinal Diseases and Treatments
- Alzheimer's disease research and treatments
- Atherosclerosis and Cardiovascular Diseases
- Energy, Environment, Economic Growth
- Sperm and Testicular Function
- Endoplasmic Reticulum Stress and Disease
- High Altitude and Hypoxia
- Phytochemical Studies and Bioactivities
- Economic and Environmental Valuation
- Nerve injury and regeneration
- Psoriasis: Treatment and Pathogenesis
- Neurological Disease Mechanisms and Treatments
Tianjin Anding Hospital
2025
Northwest A&F University
2015-2025
Dalian Medical University
2025
Tianjin Medical University
2025
Nanjing Medical University
2025
Jiangsu Province Hospital
2025
West China Hospital of Sichuan University
2024
Sichuan University
2024
Beijing Anzhen Hospital
2024
Capital Medical University
2024
The functional role of IL-1 family member 10, recently renamed IL-38, remains unknown. In the present study we aimed to elucidate biological function IL-38 and identify its receptor. Heat-killed Candida albicans was used stimulate memory T-lymphocyte cytokine production in freshly obtained human peripheral blood mononuclear cells from healthy subjects. addition recombinant (152 amino acids) inhibited T-cell cytokines IL-22 (37% decrease) IL-17 (39% decrease). reduction caused by similar that...
In the face of increasingly severe resource and environmental constraints, accelerating transformation agricultural green development through science technology innovation is an effective measure to reduce pollution improve production efficiency. From perspective multidimensional proximity, this paper expounds mechanism on spatial spillover from two perspectives: factor path product path. Based panel data 30 provinces in China 2006 2019, using gray correlation analysis method, level was...
<title>Abstract</title> Background Epigenetics modification has emerged as a potential mechanism of action for MAFLD. The histone methylase SUV39H1 is key epigenetic transcription factor that regulates adipogenesis and inflammation, but its role in MAFLD progression remains largely unknown. Methods In this study, the high fat diet (HFD) induced mice palmitic acid (PA) primary mouse hepatocytes were adopted to investigate effects mechanisms on Point mutation knockdown SET domain PA-stimulated...
<title>Abstract</title> The full text of this preprint has been withdrawn, as it was submitted in error. Therefore, the authors do not wish work to be cited a reference. Questions should directed corresponding author.
Tibetan chicken (TBC) is one of the native poultry species that well adapted to high-altitude environment Qinghai-Tibet Plateau. To elucidate genetic mechanisms underlying adaptation, transcriptomes five tissues (heart (HE), lung (LU), liver (LI), ovary (OV), and abdominal fat (AB)) were compared between TBCs Roman chickens (RMCs) inhabiting plateau for year. Moreover, weighted gene co-expression network analysis (WGCNA) was applied detect tissue-associated modules hub genes. A total 1105,...
Anthropogenic activities in the environment affect ecosystem and can play an important role selecting spreading antibiotic‐resistant bacteria (ARB) genes (ARGs). The dairy farm may serve as a hotspot reservoir for exchanging ARGs, but studies are scarce. Here, we investigated characterized extended‐spectrum β ‐lactamase producing Escherichia coli strains recovered from co‐harboring bla OXA−1 , catB3 arr-3 genes. isolates were identified by PCR, antimicrobial susceptibility testing,...
Article abstract-We report the possible existence of an inhibitory factor in CSF Parkinson9s disease patients that inhibits function and growth dopaminergic neurons rat mesencephalic culture. After 40 hours9 exposure to <10 kd fraction from PD patients, high-affinity dopamine uptake was 66% cultures exposed controls. However, number remained unchanged at this time. 90 decreased 10% controls, size remaining culture became smaller. This did not affect other types neurons. The chemical...
The aim of this study was to determine the protective effects combination ascorbic acid (Vc) and vitamin E (VE) on antioxidant enzyme activity, sperm motility, viability, acrosome integrity Qinchuan bulls after freeze-thaw.In study, we determined Vc VE activity defense system comprising glutathione peroxidase (GSH-Px), reductase (GR), catalase (CAT), superoxide dismutase (SOD).The had motility viability.With respect GR SOD, differences were observed between experimental groups with added (7...
The finding that 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) elicits parkinsonism in human beings suggests endogenous or xenobiotic neurotoxic compounds may be involved the etiology of Parkinson's disease (PD). We have shown cerebrospinal fluid (CSF) newly diagnosed and drug untreated patients with PD contains a low molecular weight substance(s) which inhibits growth function dopaminergic neurons culture. In addition, selegiline dosage below level monoamine oxidase B (MAO-B),...
The human mitochondrial tRNALeu(CUN) [hmtRNALeu(CUN)] corresponds to the most abundant codon for leucine in protein genes. Here, vitro studies reveal that U48C substitution hmtRNALeu(CUN), which pathological T12311C gene mutation, improved aminoacylation efficiency of hmtRNALeu(CUN). Enzymatic probing suggested a more flexible secondary structure wild-type hmtRNALeu(CUN) transcript compared with mutant. Structural analysis revealed flexibility facilitates T-stem slip resulting two potential...
Abstract Recently, three new B7 family members, B7-H5 (VISTA, Gi24, or Dies1), B7-H6, and B7-H7 (HHLA2) were identified. However, the functions of members remain uncertain. We expressed human B7-H5, extracellular domain IgG1 Fc Chimera in mammalian cell line investigated purified recombinant B7-H5/Fc, B7-H6/Fc, B7-H7/Fc vitro. To determine B7-H7, T cells treated with plate-bound anti-CD3 either control Fc. The cytokine levels supernatant measured using Proteome Profiler Human Cytokine Array...
The isoquinoline derivative N-methyl-6,7-dihydroxytetrahydroisoquinoline (N-methyl-norsalsolinol) is present in normal human brain and has been identified the cerebrospinal fluid of patients with Parkinson's disease (PD). Endogenously, N-methyl-norsalsolinol may be derived from dopamine by condensation aldehydes or alpha-ketoacids. In vitro experiments suggest that neurotoxic. this study, high-performance liquid chromatography electrochemical detection (HPLC-EC) was used to determine...
To investigate the potential relationship between subretinal microglia and transplanted donor photoreceptors. Photoreceptor precursors were into wild-type mice rd1 by trans-scleral injection. Immunohistochemistry was employed to detect macrophages. PlX5622 feed used achieve depletion repopulation. RNA-seq qPCR utilized evaluate gene expression. Confocal microscopy observe interaction Donor photoreceptors survived in but not after The microglial cells closely interacted with cells. While...
Objective To study the changes in gastrointestinal wall thickness, blood flow, motility, and symptoms patients with acute heart failure, to assess function by ultrasound. Methods In this study, diagnosed failure were selected as group, healthy individuals control group. Both groups collected general data completed Chinese version of symptom rating scale. Ultrasonography was used measure several abdominal vascular gastrointestinal-related indicators. Statistical analysis grouped comparison...
Abstract CD229 (SLAMF3) is a receptor protein primarily found on mature T cells, B myeloid macrophages, and thymocytes. The exact functions of this remain uncertain. Data from knockout mice showed that uniquely involved in enhancing cell activation. However, coligation TCR with anti-CD229 (mAb) anti-CD3 antibodies has been demonstrated to inhibit To study the CD229, we expressed soluble polyHistidine tagged containing mouse extracellular domain (aa48-454) investigated its function purified...