A5100610310- Circular RNAs in diseases
- HIV Research and Treatment
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Neurosurgical Procedures and Complications
- Cerebrospinal fluid and hydrocephalus
- TGF-β signaling in diseases
- RNA Research and Splicing
- MicroRNA in disease regulation
- Traumatic Brain Injury and Neurovascular Disturbances
Tianjin Huanhu Hospital
2012-2024
MicroRNA (miR)‑mediated mRNA and multiple signaling pathway dysregulations have been extensively implicated in several cancer types, including gliomas. Although previous studies reported that miR‑301a acts as an oncogene, the underlying mechanisms of initiation progression glioma remain unknown. The present study aimed to investigate involvement miR‑301a‑mediated dysregulation glioma. results identified was significantly upregulated gliomas associated with a poor prognosis based on Cancer...
Objective To investigate the effects of short hairpin RNA (shRNA) targeting Forkhead box P3 (FOXP3) gene on proliferation and apoptosis human glioma cells U87 LN229. Methods 4 plasmids containing different sequences shRNA FOXP3 1 random were transfected into LN229 mediated by Lipofectamine 2000. The expression protein was detected Western blot to screen most effective plasmid. cell CCK-8 assay flow cytometry, respectively. Results At 72 h after transfection, obviously suppressed...
The expression of transforming growth factor(TGF)-β supeffamily co-receptor (Tβ3R) Ⅲ is often lost in many kinds cancers.Tβ3RⅢ plays a role negative regulation tumorigenesis.T3RⅢ could regulate the cellular invasion,migration,proliferation and apoptosis by multiple mechanisms,such as mediating TGF-β signaling pathway,impacting mitogen-activated protein kinase(MAPK),nuclear factor-kappa B (NF-κB) Cdc42 producing soluble TβR(sTβR) Ⅲ.Defining mechanisms absence physiological functions TβR...