A5101486643- Alcohol Consumption and Health Effects
- Eicosanoids and Hypertension Pharmacology
- Effects and risks of endocrine disrupting chemicals
- Animal testing and alternatives
- Carcinogens and Genotoxicity Assessment
- Toxic Organic Pollutants Impact
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- Inflammasome and immune disorders
- Apelin-related biomedical research
- Alzheimer's disease research and treatments
- Single-cell and spatial transcriptomics
- Antioxidant Activity and Oxidative Stress
- Circular RNAs in diseases
- Obsessive-Compulsive Spectrum Disorders
- Gout, Hyperuricemia, Uric Acid
- Biochemical Acid Research Studies
- Vitamin C and Antioxidants Research
- Eating Disorders and Behaviors
- Obesity, Physical Activity, Diet
- Signaling Pathways in Disease
- Pharmacogenetics and Drug Metabolism
- Cholinesterase and Neurodegenerative Diseases
- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
Shenyang Pharmaceutical University
2024
Nanjing University of Chinese Medicine
2024
Jiangsu Province Hospital
2024
Jilin Agricultural University
2023
Shandong First Medical University
2018-2021
Center for High Pressure Science & Technology Advanced Research
2020
University of Jinan
2018-2019
Shandong Academy of Chinese Medicine
2018
Deyang Stomatological Hospital
2015
Shanghai Jiao Tong University
2015
Abstract Combination therapy has emerged as a promising approach for effective tumor treatment. However, the combination of sonodynamic (SDT) and hypoxia‐activated prodrugs (HAPs) not been explored due to contradictory requirement oxygen (O 2 ) reactive species (ROS) generation necessity avoid O activation HAPs. In this study, challenge is addressed by developing BiOCl‐Au‐Ag S Z‐scheme heterostructure nanoparticles loaded with tirapazamine (TPZ) achieve ‐independent therapy. These...
Aim: Cytochrome P450s (CYP450) enzymes regulate inflammation and atherosclerosis can affect carotid plaque stability in patients with ischemic stroke (IS).This study aimed to investigate the association of CYP450 genetic variants CYP plasma metabolite levels IS.Methods: Eleven single nucleotide polymorphisms (SNPs) genes their [20-hydroxyeicosatetraenoic acid (HETE), total epoxyeicosatrienoic acids (EETs), dihydroxyeicosatrienoic (DiHETEs)] were measured 396 IS who underwent high-resolution...
The purpose of present study is to examine whether gestational exposure two major environmental endocrine-disrupting chemicals, nonylphenol (NP) and estradiol (E2), would affect nervous system development offspring rats explore the joint effects NP E2. After impregnation, dams were assigned seven groups. first second groups received gavage with at dose levels 50 mg/kg/day (NP-L) 100 (NP-H); third fourth gavaged E2 10 μg/kg/day (E2-L) 20 (E2-H); fifth sixth [NP + (NP-E2-L) mg/kg/day+E2...
Crotonaldehyde is a ubiquitous hazardous pollutant, present in cigarette smoke and automobile exhaust endogenously generated by lipid peroxidation. Most of the current studies focus on its lung toxicity. However, there have been few investigations cardiac renal toxicity caused crotonaldehyde exposure. We hypothesized that oral intake can cause inflammatory oxidative/nitrosative damage to heart kidneys. Therefore, we treated male rats with gavage at 0, 2.5, 4.5, 8.5 mg/kg/day for 120 d...
Single-cell transcriptome analysis has provided detailed insights into the ecosystem of liver cancer. However, changes cellular and molecular components tumors in comparison with normal livers have not been described at single-cell level. Here, we performed an integrative both cancers. Principal component was firstly to delineate cell lineages tissues. Differential gene expression within major types were then analyzed between tumor samples, thus resolved type-specific alterations cancer...
Background Previous studies have shown that lifestyle was associated with depression. Thus, the aim of this study to examine causality between multiple lifestyles and depression by Mendelian randomization (MR) analysis. Methods The single-nucleotide polymorphisms (SNPs) depression, alcoholic drinks per week, sleeplessness or insomnia, body mass index (BMI), mood swings, weekly usage mobile phone in last 3 months, beef intake, cooked vegetable “smoking status: never” were acquired from...
Hyperuricemia (HUA), recognized as the fourth "high" condition following hypertension, hyperlipidemia, and hyperglycemia, is a metabolic disorder that severely impairs renal function. Spike lavender essential oil (SLEO) exhibits substantial anti-inflammatory antioxidant activities can inhibit xanthine oxidase (XOD), suggesting its potential therapeutic against HUA. This of this study aimed to analyze chemical constituents SLEO with efficacy in treating HUA explore their mechanisms action....
Crotonaldehyde is a highly toxic pollutant, widely present in tobacco smoke and automobile exhaust. Exposure to crotonaldehyde can cause hepatotoxicity induce liver tumors rats; however, the underlying mechanism unclear. Liver cells contain many mitochondria, which serve maintain energy levels body. We hypothesized that metabolism disorder caused by mitochondrial dysfunction an important of injury rats exposed crotonaldehyde. To test this, we randomly divided 40 male Wistar into four groups,...
Crotonaldehyde is a hazardous pollutant present in cigarette smoke and automobile exhausts that generated by lipid peroxidation, harmful to reproductive organs. Although we are often exposed low doses of crotonaldehyde daily, its adverse effects on the organs have not been fully elucidated. To elucidate them, administered (0, 2.5, 4.5, 8.5 mg/kg) gavage for 150 days male Wister rats, evaluated effect their testicular tissues. Body weight, testis coefficient, sperm count, motility decreased....
Objective: To investigate the effect of subchronic exposure to crotonaldehyde on reproductive damage and oxidative stress in male rate. Methods: Forty SPF Wistar rats were randomly divided into four group: a control group 3 groups, 10 per group. The each continuously administrated with (normal saline) for 1 time/d. For 128 d, doses 0.0, 2.5, 4.5, 8.5 mg/kg. After end exposure, body weight, weight testis epididymis was measured, calculating organ coefficient. left spermatozoon tail used...
This invention provides the screening methods of candidate compounds, diagnostic and treatment human cognitive diseases, also gives out several potential compounds. The establishes that FKBP52-Tau interaction a new target may be used advantageously for novel therapeutic approaches neurological disorders involving Tau dysfunction, especially Alzheimer's disease.The generally relates to neuroprotection repair in dysfunction (including disease). describes direct between FKBP52 Tau, molecules...
Objective To investigate the effects of short hairpin RNA (shRNA) targeting Forkhead box P3 (FOXP3) gene on proliferation and apoptosis human glioma cells U87 LN229. Methods 4 plasmids containing different sequences shRNA FOXP3 1 random were transfected into LN229 mediated by Lipofectamine 2000. The expression protein was detected Western blot to screen most effective plasmid. cell CCK-8 assay flow cytometry, respectively. Results At 72 h after transfection, obviously suppressed...
Objective: To observe the lung injury of male rats induced by sub-chronic exposure to crotonaldehyde, and explore possible mechanism injury. Methods: Forty SPF Wistar were randomly divided into control group 3 groups in each group, received 0.0, 2.5, 4.5, 8.5 mg/kg body weight crotonaldehyde solution for continuous intragastric administration. 120 d, once a day. After end exposure, was measured, tissues quickly separated after cervical dislocation. The organ coefficients calculated...