A5112184068- Neuropeptides and Animal Physiology
- Autophagy in Disease and Therapy
- Alzheimer's disease research and treatments
- Retinoids in leukemia and cellular processes
- Venomous Animal Envenomation and Studies
- Oropharyngeal Anatomy and Pathologies
- Natural Compounds in Disease Treatment
- Pain Mechanisms and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Acute Myeloid Leukemia Research
- Trigeminal Neuralgia and Treatments
Guangzhou University of Chinese Medicine
2024-2025
Hong Kong Baptist University
2022
Alzheimer's disease (AD), characterized by the accumulation of protein aggregates including phosphorylated Tau aggregates, is most common neurodegenerative disorder with limited therapeutic agents. Autophagy plays a critical role in degradation and transcription factor EB (TFEB) master regulator autophagy lysosomal biogenesis. Thus, small-molecule enhancers targeting TFEB hold promise for AD therapy. Here, we found that celastrol, an active ingredient isolated from root extracts Tripterygium...
ABSTRACT Background Inflammatory regulators play a fundamental role in the development of trigeminal neuralgia (TN). However, precise mechanisms and causal relationship with risk TN remain poorly understood. Methods This study aimed to assess between 41 inflammatory cytokines using Mendelian randomization (MR) analysis. A two‐sample MR approach was utilized, employing genetic variation data on from large publicly available genome‐wide association (GWAS) comprising 1777 cases European...
Acute promyelocytic leukemia (APL) cells exhibit disrupted regulation of cell death and differentiation, therefore the fate these leukemic is unclear. Here, we provide first evidence that a small percentage APL undergo novel pathway by releasing extracellular DNA traps (ETs) in untreated patients. Both NB4 stimulated with serum had nuclear budding vesicles filled chromatin leaked to space when membranes ruptured. Using immunofluorescence, found undergoing ETosis extruded lattice-like...
Transmembrane member 16A (TMEM16A) exhibits a negative correlation with autophagy, though the underlying mechanism remains elusive. This study investigates between TMEM16A and autophagy by inducing in DRG neuronal cells using Rapamycin. Results indicated that interference augmented cell viability reduced Rapamycin-induced apoptosis. Autophagosome formation increased but decreased upon overexpression. A similar increase autophagosomes was observed SB203580 treatment. Furthermore, suppressed...