A5050189746- Renal Transplantation Outcomes and Treatments
- Multiple Sclerosis Research Studies
- SARS-CoV-2 and COVID-19 Research
- Peripheral Neuropathies and Disorders
- Immunotherapy and Immune Responses
- Organ Transplantation Techniques and Outcomes
- Drug-Induced Adverse Reactions
- Organ Donation and Transplantation
- HIV/AIDS Research and Interventions
- Autoimmune Neurological Disorders and Treatments
- HIV/AIDS drug development and treatment
- Child Nutrition and Feeding Issues
- interferon and immune responses
- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Cell Adhesion Molecules Research
- Immunodeficiency and Autoimmune Disorders
- Hepatitis B Virus Studies
- Immune responses and vaccinations
- Chronic Lymphocytic Leukemia Research
- Organ and Tissue Transplantation Research
- Monoclonal and Polyclonal Antibodies Research
- Renal and Vascular Pathologies
- Renal Diseases and Glomerulopathies
University of Modena and Reggio Emilia
2023-2025
Azienda Ospedaliero-Universitaria di Modena
2024
Azienda Unita' Sanitaria Locale Di Modena
2023-2024
University of Cincinnati
2004-2011
Christ Hospital
2004
Abstract Disease-modifying therapies (DMT) administered to patients with multiple sclerosis (MS) can influence immune responses SARS-CoV-2 and vaccine efficacy. However, data on the detailed phenotypic, functional metabolic characteristics of antigen (Ag)-specific cells following third dose mRNA remain scarce. Here, using flow cytometry 45-parameter mass cytometry, we broadly investigate phenotype, function single-cell profile SARS-CoV-2-specific T B up 8 months after in a cohort 94 MS...
The kappa index is a well-established marker of intrathecal synthesis (IS) immunoglobulin (Ig). Routinely used for diagnostic aims, IgG IS, which can be assessed quantitatively (ad hoc formulas) or qualitatively (oligoclonal bands, OCBs), may fail in detecting humoral immune response within the central nervous system (CNS). main aim this study was to evaluate its ability detect presence CNS immunity and associate it with distinct group disorders, absence IS/OCBs. Within index-positive,...
Clinical, pathological, and imaging evidence in multiple sclerosis (MS) shows that inflammation starts early progresses with age. B cells play a central role this process, contributing to cytokine production, defective regulatory functions, abnormal immunoglobulin even the nervous system. Anti-CD20 (aCD20) therapies, which deplete CD20+ cells, are effective for both relapsing-remitting (RR) progressive-relapsing (PR) MS. While against MS symptoms lesions detectable by magnetic resonance...
Clinical, pathological, and imaging evidence in multiple sclerosis (MS) shows that inflammation starts early progresses with age. B cells play a central role this process, contributing to cytokine production, defective regulatory functions, abnormal immunoglobulin even the nervous system. Anti-CD20 (aCD20) therapies, which deplete CD20+ cells, are largely used treatment of both relapsing remitting (RR) progressive (PR) forms MS. Although effective against MS symptoms lesions detectable by...
<title>Abstract</title> Disease modifying therapies (DMT) assumed by patients affected multiple sclerosis (MS) can influence immune response to SARS-CoV-2 and vaccination efficacy. Even if in most treated vaccine-induced humoral cellular responses be attenuated, scanty data exist on detailed phenotypic, functional metabolic characteristics of antigen (Ag)-specific cells following the third dose vaccine. Here, using flow cytometry 45-parameter mass cytometry, we broadly investigate phenotype,...
Walsh, R. C.; Shields, A. R.; Wall, G. E.; Girnita, A.; Brailey, P.; Cardi, M.; Govil, Mogilishetty, G.; Alloway, Woodle, E. S. Author Information
Shields, A. R.; Alloway, R. Govil, A.; Cardi, M.; Safdar, S.; Tevar, Arend, L.; Girnita, Everly, J.; Woodle, E. S. Author Information
Walsh, R. C.1; Girnita, A.2; Wall, G. E.3; Shields, A. R.4; Brailey, P.2; Mogilishetty, G.5; Govil, A.6; Cardi, M.7; Alloway, R.5; Woodle, E. S.8 Author Information
P398 Aims: African Americans (AAs) have historically been considered high-risk renal transplant recipients due to increased rejection rates and reduced long-term graft survival. As a result, AAs are often excluded from corticosteroid withdrawal (CSWD) protocols. Modern immunosuppression (IS) has rejections improved survival in may allow successful CSWD. The purpose of the study was determine if could receive benefits early CSWD without an increase risk loss. Methods: Outcomes 56 were...