A5026153925- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Mesenchymal stem cell research
- Synthesis of Organic Compounds
- Medical History and Innovations
- Ophthalmology and Eye Disorders
- Cell death mechanisms and regulation
- Trypanosoma species research and implications
- Connexins and lens biology
- History of Medicine Studies
- Soft tissue tumor case studies
- Metabolism, Diabetes, and Cancer
- Malaria Research and Control
- Ubiquitin and proteasome pathways
- Wound Healing and Treatments
- RNA Interference and Gene Delivery
- Proteoglycans and glycosaminoglycans research
- Cellular transport and secretion
- Cancer and Skin Lesions
- Protein Kinase Regulation and GTPase Signaling
- Ocular Oncology and Treatments
- Virus-based gene therapy research
Columbia University
2024
Second Affiliated Hospital of Zhejiang University
2001-2023
Weill Cornell Medicine
2023
Cornell University
2023
Zhejiang University
2004-2012
Chung-Ang University Hospital
2004
Abstract The proteasome of the malaria parasite Plasmodium falciparum (Pf20S) is an advantageous drug target because its inhibition kills P. in multiple stages life cycle and synergizes with artemisinins. We recently developed a macrocyclic peptide, TDI-8304, that highly selective for Pf20S over human proteasomes potent vitro vivo against . A mutation β6 subunit, A117D, confers resistance to yet enhances both enzyme anti-parasite activity tripeptide vinyl sulfone β2 inhibitor, WLW-vs. Here...
Objective: To investigate the histopathological classification of orbital space-occupying lesions. Methods: This is a retrospective case series study. The clinical and pathological data 1 913 tissue specimens from patients with lesions orbit which were examined in Second Affiliated Hospital, Zhejiang University School Medicine January 2000 to December 2021 collected. mass classified based on histogenesis, nature age. Results: There males (47.7%) 000 females (52.3%). benign 489 (77.8%)...
Blepharoptosis in children is one of the common pediatric eye diseases. It not only a matter aesthetics, but also affects visual and psychological development. How to choose right time operate has been controversial clinical practice. Based on domestic foreign research progress experience, we propose that factors, such as etiology blepharoptosis, development characteristics children, developmental eyelid-related muscles, types should be considered for selection timing surgery personalized...