A5085221967- RNA Research and Splicing
- DNA Repair Mechanisms
- Telomeres, Telomerase, and Senescence
- 3D Printing in Biomedical Research
- CRISPR and Genetic Engineering
- Mitochondrial Function and Pathology
- Pluripotent Stem Cells Research
Shaoxing People's Hospital
2024
Guizhou University
2023
Abstract Naive human embryonic stem cells (hESCs) that resemble the pre-implantation epiblasts are fueled by a combination of aerobic glycolysis and oxidative phosphorylation, but their mitochondrial regulators poorly understood. Here we report that, proline dehydrogenase (PRODH), mitochondria-localized metabolism enzyme, is dramatically upregulated in naive hESCs compared to primed counterparts. The upregulation PRODH induced reduction c-Myc expression dependent on PD0325901, MEK inhibitor...
Background and Purpose: The Bazhen decoction is one of the most extensively used Traditional Chinese medicine (TCM) prescriptions for anti-aging. However, due to complicity components, pharmacological mechanism still limited. Experimental approach: We applied RNA sequencing transcriptome analysis get full view signaling pathways regulated by in wild type cell background. By using progeroid cells derived from Werner syndrome mice, we Western blot, Immunofluorescence, flow cytometry telomere...
<title>Abstract</title> <bold>Background</bold>The Bazhen decoction is one of the most extensively used Traditional Chinese medicine (TCM) prescriptions for anti-aging. However, due to complicity components, pharmacological mechanism still limited.<bold>Methods</bold>We applied RNA sequencing and transcriptome analysis get full view signaling pathways regulated by in wild type cell background. By using progeroid cells derived from Werner syndrome mice, we Western blot, Immunofluorescence,...